Significance of Neutrophil-to-Lymphocyte Ratio in Predicting the Efficacy of Anamorelin for Cancer Cachexia DOI Open Access
Yusuke Nakazawa,

Kanako Watanabe,

Ako Gannichida

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Introduction Cancer cachexia is a multifactorial syndrome characterized by persistent skeletal muscle loss and poor prognosis in cancer patients. Anamorelin, ghrelin receptor agonist, may alleviate symptoms increasing appetite promoting weight gain, though its clinical efficacy remains insufficiently explored. Given the involvement of cancer-inducing cytokines cachexia, neutrophil-to-lymphocyte ratio (NLR), an inflammatory biomarker, serve as predictor therapeutic outcomes this condition. This study aimed to evaluate role NLR assessing effects anamorelin prognostic value patients with cachexia. Methods included associated pancreatic, non-small cell lung, gastric, or colorectal who received between April 2021 December 2023. Patients were categorized based on their (<5 ≥5) at four weeks post-anamorelin administration. Changes one-year overall survival (OS) rates compared groups. Baseline was also assessed for impact outcomes. Statistical analyses Kaplan-Meier method analysis, receiver operating characteristic (ROC) analysis used determine optimal baseline cutoff achieving posttreatment < 5. Results Of 66 anamorelin, 42 had pancreatic cancer, 14 lung 6 gastric 4 cancer. stratified into two groups weeks: 5 (n = 50, 76%) ≥ 16, 24%). In group, mean decreased significantly from 3.71 2.44, while it increased 5.70 9.52. The OS higher group (62%, n 31/50) (33%, 5/16). classification, however, showed no significant difference (58%, 21/51) (41%, 6/15). ROC identified 4.4 predictive (AUC, 0.78; sensitivity, 80%; specificity, 75%), observed (68%, 29/42) (34%, 8/24). Conclusions These findings highlight potential marker suggest that initiating treatment likely improve outcomes, emphasizing importance NLR-based interventions.

Language: Английский

Significance of Neutrophil-to-Lymphocyte Ratio in Predicting the Efficacy of Anamorelin for Cancer Cachexia DOI Open Access
Yusuke Nakazawa,

Kanako Watanabe,

Ako Gannichida

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Introduction Cancer cachexia is a multifactorial syndrome characterized by persistent skeletal muscle loss and poor prognosis in cancer patients. Anamorelin, ghrelin receptor agonist, may alleviate symptoms increasing appetite promoting weight gain, though its clinical efficacy remains insufficiently explored. Given the involvement of cancer-inducing cytokines cachexia, neutrophil-to-lymphocyte ratio (NLR), an inflammatory biomarker, serve as predictor therapeutic outcomes this condition. This study aimed to evaluate role NLR assessing effects anamorelin prognostic value patients with cachexia. Methods included associated pancreatic, non-small cell lung, gastric, or colorectal who received between April 2021 December 2023. Patients were categorized based on their (<5 ≥5) at four weeks post-anamorelin administration. Changes one-year overall survival (OS) rates compared groups. Baseline was also assessed for impact outcomes. Statistical analyses Kaplan-Meier method analysis, receiver operating characteristic (ROC) analysis used determine optimal baseline cutoff achieving posttreatment < 5. Results Of 66 anamorelin, 42 had pancreatic cancer, 14 lung 6 gastric 4 cancer. stratified into two groups weeks: 5 (n = 50, 76%) ≥ 16, 24%). In group, mean decreased significantly from 3.71 2.44, while it increased 5.70 9.52. The OS higher group (62%, n 31/50) (33%, 5/16). classification, however, showed no significant difference (58%, 21/51) (41%, 6/15). ROC identified 4.4 predictive (AUC, 0.78; sensitivity, 80%; specificity, 75%), observed (68%, 29/42) (34%, 8/24). Conclusions These findings highlight potential marker suggest that initiating treatment likely improve outcomes, emphasizing importance NLR-based interventions.

Language: Английский

Citations

1