Anthraquinones and Aloe Vera Extracts as Potential Modulators of Inflammaging Mechanisms: A Translational Approach from Autoimmune to Onco-Hematological Diseases DOI Creative Commons
Raffaele Cordiano, Santino Caserta, Paola Lucia Minciullo

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1251 - 1251

Published: March 11, 2025

Inflammaging is a chronic, low-grade inflammatory state that contributes to age-related diseases, including cardiovascular disorders, osteoporosis, neurodegeneration, and cancer. This process involves immunosenescence, oxidative stress, immune aging, all of which contribute the breakdown tolerance onset autoimmune disorders. Aloe vera (AV) has recently gained attention for its immunomodulatory, anti-inflammatory, antioxidant properties. review explores effects AV extracts anthraquinones (e.g., aloe–emodin, emodin, aloin) on key inflammaging-driven mechanisms in autoimmunity. Our analysis highlights AV’s ability regulate hormone balance, autoantibody production, cytokine/chemokine signaling (such as interleukin-1β, tumor necrosis factor-α, interferon-γ). It modulates pathways, mitogen-activated protein kinases (MAPKs) phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT), thereby inhibiting nuclear factor kappa-light-chain-enhancer activated B-cell (NF-κB) activation. Additionally, enhances defenses restores balance by reducing Th1/Th17 subsets while promoting Th2-mediated regulation. Notably, also inflammasome-mediated counteracts driven autophagy-related processes. These position potential integrative approach mitigating Furthermore, inflammaging increasingly recognized onco-hematological AV-based strategies may offer novel therapeutic avenues. Future studies should focus clinical validation, optimizing formulations, expanding applications broader immune-mediated

Language: Английский

Anthraquinones and Aloe Vera Extracts as Potential Modulators of Inflammaging Mechanisms: A Translational Approach from Autoimmune to Onco-Hematological Diseases DOI Creative Commons
Raffaele Cordiano, Santino Caserta, Paola Lucia Minciullo

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1251 - 1251

Published: March 11, 2025

Inflammaging is a chronic, low-grade inflammatory state that contributes to age-related diseases, including cardiovascular disorders, osteoporosis, neurodegeneration, and cancer. This process involves immunosenescence, oxidative stress, immune aging, all of which contribute the breakdown tolerance onset autoimmune disorders. Aloe vera (AV) has recently gained attention for its immunomodulatory, anti-inflammatory, antioxidant properties. review explores effects AV extracts anthraquinones (e.g., aloe–emodin, emodin, aloin) on key inflammaging-driven mechanisms in autoimmunity. Our analysis highlights AV’s ability regulate hormone balance, autoantibody production, cytokine/chemokine signaling (such as interleukin-1β, tumor necrosis factor-α, interferon-γ). It modulates pathways, mitogen-activated protein kinases (MAPKs) phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT), thereby inhibiting nuclear factor kappa-light-chain-enhancer activated B-cell (NF-κB) activation. Additionally, enhances defenses restores balance by reducing Th1/Th17 subsets while promoting Th2-mediated regulation. Notably, also inflammasome-mediated counteracts driven autophagy-related processes. These position potential integrative approach mitigating Furthermore, inflammaging increasingly recognized onco-hematological AV-based strategies may offer novel therapeutic avenues. Future studies should focus clinical validation, optimizing formulations, expanding applications broader immune-mediated

Language: Английский

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