Efficacy of Tecovirimat and Cidofovir Against MPXV-Induced Pneumonia, Skin Lesion, and Arthritis in the High-Risk Population-Relevant SCID Mouse Model DOI
Huijun Lu, Xinyu Cao, Ning Shi

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Abstract On February 27, 2025, WHO maintained monkeypox as a PHEIC following its third round of assessment. Human virus infection primarily manifests with fever, lymphadenopathy, and rash. Severe cases may develop pneumonia, encephalitis, myocarditis arthritis. After evaluation three murine models (ICR, IFNAR1−/−, SCID), we identified SCID mice stable hosts for clade IIb, modeling high-risk populations like patients HIV. Three models, characterized by rash, arthritis, were established the pharmacodynamic tecovirimat cidofovir. Both drugs decreased titer in target organs during early ensured 100% survival. As limitation, cidofovir failed to inhibit viral DNA load skin lesions, monotherapy or was ineffective prolonged intradermal infections. These data indicate that therapeutic efficacy is contingent upon distinct disease phenotypes progression stages, underscoring necessity novel interventions against monkeypox.

Language: Английский

Efficacy of Tecovirimat and Cidofovir Against MPXV-Induced Pneumonia, Skin Lesion, and Arthritis in the High-Risk Population-Relevant SCID Mouse Model DOI
Huijun Lu, Xinyu Cao, Ning Shi

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Abstract On February 27, 2025, WHO maintained monkeypox as a PHEIC following its third round of assessment. Human virus infection primarily manifests with fever, lymphadenopathy, and rash. Severe cases may develop pneumonia, encephalitis, myocarditis arthritis. After evaluation three murine models (ICR, IFNAR1−/−, SCID), we identified SCID mice stable hosts for clade IIb, modeling high-risk populations like patients HIV. Three models, characterized by rash, arthritis, were established the pharmacodynamic tecovirimat cidofovir. Both drugs decreased titer in target organs during early ensured 100% survival. As limitation, cidofovir failed to inhibit viral DNA load skin lesions, monotherapy or was ineffective prolonged intradermal infections. These data indicate that therapeutic efficacy is contingent upon distinct disease phenotypes progression stages, underscoring necessity novel interventions against monkeypox.

Language: Английский

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