Current update on pharmacological strategies of penile cancer DOI

Sameer Deshmukh,

Kaustubh S. Chaudhari, Arnab Basu

et al.

Expert Opinion on Pharmacotherapy, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Penile cancer considered an orphan malignancy - due to its low incidence makes research and clinical development challenging. The limited understanding of molecular biology genetic landscape adds the complexity developing effective therapies. This review takes a closer look at how penile treatment has evolved from traditional modes like surgery radiation now vaccines over period time. Breakthroughs in immunotherapy offer ray hope alongside treatments adoptive T-cell therapies (ATCT), anti-angiogenic agents, Antibody-Drug Conjugates (ADCs) Bispecific Antibodies (BsAbs). integration targeted therapy demonstrated promising results, particularly patients with advanced or metastatic disease. While these advancements bring hope, more is needed refine strategies benefit novel approaches.

Language: Английский

Current update on pharmacological strategies of penile cancer DOI

Sameer Deshmukh,

Kaustubh S. Chaudhari, Arnab Basu

et al.

Expert Opinion on Pharmacotherapy, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Penile cancer considered an orphan malignancy - due to its low incidence makes research and clinical development challenging. The limited understanding of molecular biology genetic landscape adds the complexity developing effective therapies. This review takes a closer look at how penile treatment has evolved from traditional modes like surgery radiation now vaccines over period time. Breakthroughs in immunotherapy offer ray hope alongside treatments adoptive T-cell therapies (ATCT), anti-angiogenic agents, Antibody-Drug Conjugates (ADCs) Bispecific Antibodies (BsAbs). integration targeted therapy demonstrated promising results, particularly patients with advanced or metastatic disease. While these advancements bring hope, more is needed refine strategies benefit novel approaches.

Language: Английский

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