Temporo-spatial Theory of Consciousness (TTC) – Bridging the gap of neuronal activity and phenomenal states

Behavioural Brain Research, Journal Year: 2022, Volume and Issue: 424, P. 113788 - 113788

Published: Feb. 8, 2022

Language: Английский

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Toward naturalistic neuroscience: Mechanisms underlying the flattening of brain hierarchy in movie-watching compared to rest and task

Science Advances, Journal Year: 2023, Volume and Issue: 9(2)

Published: Jan. 13, 2023

Identifying the functional specialization of brain has moved from using cognitive tasks and resting state to ecological relevant, naturalistic movies. We leveraged a large-scale neuroimaging dataset directly investigate hierarchical reorganization activity when watching films compared performing seven resting. A thermodynamics-inspired whole-brain model paradigm revealed generative underlying mechanisms for changing balance in causal interactions between regions different conditions. Paradoxically, hierarchy is flatter movie-watching, level nonreversibility significantly smaller comparison both rest tasks, where latter turn have highest levels nonreversibility. The were by model-based effective connectivity (GEC). Naturalistic could therefore provide fast convenient way measure important changes GEC (integrating anatomical connectivity) found in, example, neuropsychiatric disorders. Overall, this study demonstrates benefits moving toward more neuroscience.

Language: Английский

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Beyond task response—Pre-stimulus activity modulates contents of consciousness

Physics of Life Reviews, Journal Year: 2024, Volume and Issue: 49, P. 19 - 37

Published: March 4, 2024

Language: Английский

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Stimulus-Induced Changes in 1/f-like Background Activity in EEG

Journal of Neuroscience, Journal Year: 2022, Volume and Issue: 42(37), P. 7144 - 7151

Published: Aug. 15, 2022

Research into the nature of 1/f-like, nonoscillatory electrophysiological activity has grown exponentially in recent years cognitive neuroscience. The shape this been linked to balance between excitatory and inhibitory neural circuits, which is thought be important for information processing. However, date, it not known whether presentation a stimulus induces changes parameters 1/f scalp recordings, separable from event-related potentials (ERPs). Here, we analyzed broadband human EEG both before after removing ERPs demonstrate their confounding effect, establish there are genuine stimulus-induced 1/f. Using data passive an active auditory task (n = 23, 61% female), found that post-event spectra 2 25 Hz differed significantly pre-event even frequency-content ERPs. Further, significant portion difference could accounted by rotational shift activity, manifesting as increase low decrease high frequencies. Importantly, magnitude was related attentional demands task. This change consistent with increased inhibition following onset, likely reflects disruption ongoing proportional processing demands. Finally, these findings contradict central assumption baseline normalization strategies time-frequency analyses, namely, background stationary across time. As such, they have far-reaching consequences relevant several subfields SIGNIFICANCE STATEMENT Interest functional role 1/f-like brain growing Yet, no study date demonstrated clear relationship investigating effects on its noninvasive recordings activity. demonstrate, first time, stimuli induce detectable at lower frequencies independent occurrence potentials. These suggest presence large-scale largest when novel, indicate analysis oscillations untenable. results cut

Language: Английский

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Aperiodic neural activity reflects metacontrol

Cerebral Cortex, Journal Year: 2023, Volume and Issue: 33(12), P. 7941 - 7951

Published: March 16, 2023

Abstract Higher-level cognitive functions are mediated via complex oscillatory activity patterns and its analysis is dominating neuroscience research. However, besides (period) activity, also aperiodic constitutes neural dynamics, but relevance for higher-level only beginning to be understood. The present study examined whether the broadband EEG reflects principles of metacontrol. Metacontrol conceptualizes it more useful engage in flexible processing incoming information or shield processes from (persistence-heavy processing). We behavioral data a sample n = 191 healthy participants performing Simon Go/NoGo task that can assumed induce different metacontrol states (persistence-biased vs. flexibility-biased). Aperiodic was estimated using FOOOF toolbox power spectrum. There higher exponent offset NoGo trials compared with Go trials, incongruent (Go) congruent trials. Thus, increases during persistence-heavy processing, decreases flexibility-heavy processing. These findings link features signal concepts describing dynamics how control modes applied. Therefore, substantially extends importance understanding functions.

Language: Английский

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Tracing conflict-induced cognitive-control adjustments over time using aperiodic EEG activity

Cerebral Cortex, Journal Year: 2024, Volume and Issue: 34(5)

Published: April 20, 2024

Cognitive-control theories assume that the experience of response conflict can trigger control adjustments. However, while some approaches focus on adjustments impact selection present (in trial N), other in next upcoming (N + 1). We aimed to trace over time by quantifying cortical noise means fitting oscillations and one f algorithm, a measure aperiodic activity. As predicted, trials increased exponent large sample 171 healthy adults, thus indicating reduction. While this adjustment was visible N already, it did not affect before trial. This suggests do ongoing response-selection processes but prepare system for tighter interpret findings terms conflict-induced switch from metacontrol flexibility persistence, accompanied or even implemented reduction noise.

Language: Английский

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From Shorter to Longer Timescales: Converging Integrated Information Theory (IIT) with the Temporo-Spatial Theory of Consciousness (TTC)

Entropy, Journal Year: 2022, Volume and Issue: 24(2), P. 270 - 270

Published: Feb. 13, 2022

Time is a key element of consciousness as it includes multiple timescales from shorter to longer ones. This reflected in our experience various short-term phenomenal contents at discrete points time part an ongoing, more continuous, and long-term 'stream consciousness'. Can Integrated Information Theory (IIT) account for this multitude consciousness? According the theory, relevant spatiotemporal scale one which system reaches maximum cause-effect power; IIT currently predicts that occurs on order short timescales, namely, between 100 300 ms (theta alpha frequency range). can well integration single inputs into particular content. However, such leave open temporal relation specific others during course ongoing time, is, stream consciousness. For purpose, we converge with Temporo-spatial Consciousness (TTC), which, assuming different take view other over time. On neuronal side, detailed by considering those mechanisms driving non-additive interaction pre-stimulus activity input resulting stimulus-related activity. Due their interaction, not only integrated 100-300 (alpha theta frequencies) (as predicted IIT) but, same also virtually expanded its (and spatial) features; related (delta slower are carried Such pre-stimulus-input amounts temporo-spatial expansion mechanism TTC constitution including embedding or nesting within dynamic, i.e., In conclusion, propose converging postulated (100-300 range) (in delta TTC.

Language: Английский

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Altered brain dynamics index levels of arousal in complete locked-in syndrome

Communications Biology, Journal Year: 2023, Volume and Issue: 6(1)

Published: July 20, 2023

Complete locked-in syndrome (CLIS) resulting from late-stage amyotrophic lateral sclerosis (ALS) is characterised by loss of motor function and eye movements. The absence behavioural indicators consciousness makes the search for neuronal correlates as possible biomarkers clinically ethically urgent. EEG-based measures brain dynamics such power-law exponent (PLE) Lempel-Ziv complexity (LZC) have been shown to explanatory power may provide indices patients with CLIS. Here, we validated PLE LZC (calculated in a dynamic way) benchmarks wide range arousal states across different reference (e.g., awake, sleep stages, ketamine, sevoflurane). We show tendency toward high low LZC, intra-subject fluctuations inter-subject variability cohort CLIS values graded along our data sets. In conclusion, changes indicate altered Specifically, are potentially relevant identify or diagnose level determine optimal time point treatment, including communication attempts.

Language: Английский

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Scale-free dynamics in the core-periphery topography and task alignment decline from conscious to unconscious states

Communications Biology, Journal Year: 2023, Volume and Issue: 6(1)

Published: May 9, 2023

Abstract Scale-free physiological processes are ubiquitous in the human organism. Resting-state functional MRI studies observed loss of scale-free dynamics under anesthesia. In contrast, modulation during task-related activity remains an open question. We investigate cerebral cortex’s unimodal periphery and transmodal core topography rest task states three conscious levels (awake, sedation, anesthesia) complemented by computational modelling (Stuart-Landau model). The empirical findings demonstrate that brain’s intrinsic core-periphery anesthesia, where pink noise transforms into white noise, disrupts neuronal alignment with task’s temporal structure. model shows stimuli’s dynamics, namely distinguishes from brown also modulate activity. Together, we provide evidence for two mechanisms consciousness, temporo-spatial nestedness alignment, suggested Temporo-Spatial Theory Consciousness (TTC).

Language: Английский

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Neurophysiological processes reflecting the effects of the immediate past during the dynamic management of actions

NeuroImage, Journal Year: 2024, Volume and Issue: 288, P. 120526 - 120526

Published: Jan. 26, 2024

In recent years, there has been many efforts to establish a comprehensive theoretical framework explaining the working mechanisms involved in perception-action integration. This stresses importance of immediate past on supporting The present study investigates neurophysiological principles dynamic bindings, particularly considering influence history action control mechanisms. For this purpose, we conducted an established stimulus-response binding paradigm during EEG recording. SR-task measures terms accuracy and reaction time differences depending degree feature overlap between conditions. Alpha, beta theta band activity distinct domains as well associated brain regions were investigated applying time-frequency analyses, beamforming approach correlation analyses. We demonstrate, for first time, interdependencies neuronal processes relying past. reconfiguration seems overwrite immediately preceding processes. analyses revealed modulations (TBA), alpha (ABA) (BBA) connection with fronto-temporal structures assumptions considered conceptual framework. close interplay attentional modulation by gating irrelevant information retrieval (TBA) is reflected ABA all pre-probe-intervals post-probe TBA. Likewise, role BBA maintaining event file until corroborated TBA-associated codes. Following execution, TBA shifted towards visual association cortices probably reflecting preparation upcoming information, while continue reflect selection goal-directed behavior. work provides empirical support concepts about management perception action.

Language: Английский

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