International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(6), P. 5697 - 5697
Published: March 16, 2023
Alzheimer’s
disease
(AD)
is
a
neurodegenerative
disorder
characterized
by
memory
loss
and
personality
changes
that
ultimately
lead
to
dementia.
Currently,
50
million
people
worldwide
suffer
from
dementia
related
AD,
the
pathogenesis
underlying
AD
pathology
cognitive
decline
unknown.
While
primarily
neurological
of
brain,
individuals
with
often
experience
intestinal
disorders,
gut
abnormalities
have
been
implicated
as
major
risk
factor
in
development
relevant
However,
mechanisms
mediate
injury
contribute
vicious
cycle
between
brain
remain
In
present
study,
bioinformatics
analysis
was
performed
on
proteomics
data
variously
aged
mouse
colon
tissues.
We
found
levels
integrin
β3
β-galactosidase
(β-gal),
two
markers
cellular
senescence,
increased
age
colonic
tissue
mice
AD.
The
advanced
artificial
intelligence
(AI)-based
prediction
also
demonstrated
association
β-gal
phenotypes.
Moreover,
we
showed
elevated
were
accompanied
senescence
phenotypes
immune
cell
accumulation
tissue.
Further,
genetic
downregulation
abolished
upregulated
inflammatory
responses
epithelial
cells
conditions
associated
provide
new
understanding
molecular
actions
underpinning
during
suggest
may
function
novel
target
mediating
this
disease.
Brain,
Journal Year:
2023,
Volume and Issue:
146(12), P. 4916 - 4934
Published: Oct. 18, 2023
Alzheimer's
disease
is
a
complex
neurodegenerative
disorder
leading
to
decline
in
cognitive
function
and
mental
health.
Recent
research
has
positioned
the
gut
microbiota
as
an
important
susceptibility
factor
by
showing
specific
alterations
microbiome
composition
of
patients
rodent
models.
However,
it
unknown
whether
are
causal
manifestation
symptoms.
To
understand
involvement
patient
host
physiology
behaviour,
we
transplanted
faecal
from
age-matched
healthy
controls
into
microbiota-depleted
young
adult
rats.
We
found
impairments
behaviours
reliant
on
hippocampal
neurogenesis,
essential
process
for
certain
memory
functions
mood,
resulting
transplants.
Notably,
severity
correlated
with
clinical
scores
donor
patients.
Discrete
changes
rat
caecal
metabolome
were
also
evident.
As
neurogenesis
cannot
be
measured
living
humans
but
modulated
circulatory
systemic
environment,
assessed
impact
environment
proxy
readouts.
Serum
decreased
human
cells
vitro
associated
key
microbial
genera.
Our
findings
reveal
first
time,
that
symptoms
can
transferred
organism
via
microbiota,
confirming
role
disease,
highlight
converging
central
cellular
regulating
gut-mediated
factors
Alzheimer's.
Geomicrobiology Journal,
Journal Year:
2023,
Volume and Issue:
41(4), P. 335 - 344
Published: July 19, 2023
The
potential
to
subsidize
the
development
of
areas
furnished
with
ores
is
essential
for
producing
supplies,
services,
and
infrastructure
that
get
a
better
social
life
quality.
Bauxite
mining
foremost
open-cast
bauxite
only
material
manufacturing
aluminum
metals
used
as
prominent
industrial
raw
material.
Demand
has
grown
enormously
because
increased
population
economic
growth
it
required
production
many
other
metals.
A
huge
amount
residues
are
produced
during
from
ore
which
tremendously
influences
environment
public
health.
Production
waste
leads
diminishing
soil
productivity
farming
food
yields.
Soil
water
also
contaminated
by
addition
heavy
metals,
iron
oxide,
hydroxide,
can
prejudice
Microorganisms
degrade
detoxify
pollutants
into
nontoxic
organic
form
helpful
environment.
Bioremediation
been
promising
method
remove
contaminants
using
microorganisms.
This
enables
adsorption,
accumulation,
degradation,
utilization
emerging
nutrient
resources
microbial
communities
their
sustenance.
Sustainable
management
recovery
wastes
mainly
indispensable
in
this
high
time.
review
article
evaluates
effect
on
its
consequences
human
health;
emphasizes
biological
remediation
strategy
focuses
sustainable
residues.
Aging and Disease,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Aging
in
the
healthy
brain
is
characterized
by
a
low-grade,
chronic,
and
sterile
inflammatory
process
known
as
neuroinflammaging.
This
condition,
mainly
consisting
an
up-regulation
of
response
at
level,
contributes
to
pathogenesis
age-related
neurodegenerative
disorders.
Development
this
proinflammatory
state
involves
interaction
between
genetic
environmental
factors,
able
induce
epigenetic
modifications.
Indeed,
exposure
compounds,
drugs,
infections,
can
contribute
modifications
DNA
methylome,
histone
fold
proteins,
nucleosome
positioning,
leading
modulation
neuroinflammatory
responses.
Furthermore,
some
modifiers,
which
combine
interact
during
life
course,
modeling
epigenome
dynamics
sustain,
or
dampen
phenotype.
The
aim
review
summarize
current
knowledge
about
neuroinflammaging
with
particular
focus
on
mechanisms
underlying
onset
progression
cascades
central
nervous
system;
furthermore,
we
describe
diagnostic
biomarkers
that
may
increase
accuracy
help
tailor
therapeutic
strategies
patients
diseases.
Microbial Biotechnology,
Journal Year:
2024,
Volume and Issue:
17(4)
Published: April 1, 2024
Abstract
Alzheimer's
disease
is
a
complex
and
progressive
condition
that
affects
essential
neurological
functions
such
as
memory
reasoning.
In
the
brain,
neuronal
loss,
synaptic
dysfunction,
proteinopathy,
neurofibrillary
tangles,
neuroinflammation
are
hallmarks
of
pathophysiology.
addition,
recent
evidence
has
highlighted
microbes,
whether
commensal
or
pathogenic,
also
have
ability
to
interact
with
their
host
regulate
its
immune
system,
therefore
participating
in
exchanges
lead
peripheral
inflammation
neuropathology.
Because
this
intimate
relationship,
bacteria,
viruses,
fungi,
protozoa
been
implicated
development
disease.
Here,
we
bring
together
current
most
role
microbes
disease,
raising
burning
questions
need
be
addressed
guide
therapeutic
approaches
potential
prophylactic
strategies.
Neuropsychopharmacology,
Journal Year:
2024,
Volume and Issue:
49(10), P. 1559 - 1568
Published: March 23, 2024
Abstract
Meta-analysis
of
genome-wide
association
study
data
has
implicated
PDE4B
in
the
pathogenesis
Alzheimer’s
disease
(AD),
leading
cause
senile
dementia.
encodes
one
four
subtypes
cyclic
adenosine
monophosphate
(cAMP)-specific
phosphodiesterase-4
(PDE4A–D).
To
interrogate
involvement
manifestation
AD-related
phenotypes,
effects
a
hypomorphic
mutation
(
Pde4b
Y358C
)
that
decreases
PDE4B’s
cAMP
hydrolytic
activity
were
evaluated
App
NL-G-F
knock-in
mouse
model
AD
using
Barnes
maze
test
spatial
memory,
14
C-2-deoxyglucose
autoradiography,
thioflavin-S
staining
β-amyloid
(Aβ)
plaques,
and
inflammatory
marker
assay
transcriptomic
analysis
(RNA
sequencing)
cerebral
cortical
tissue.
At
12
months
age,
mice
exhibited
memory
brain
metabolism
deficits,
which
prevented
by
/
mice,
without
decrease
Aβ
plaque
burden.
RNA
sequencing
revealed
that,
among
531
transcripts
differentially
expressed
versus
wild-type
only
13
from
genes
–
Ide
,
Btaf1
Padi2,
C1qb
identifying
their
potential
protective
effect
PDE4B.
Our
demonstrate
glucose
deficits
12-month-old
are
targeted
inhibition
our
knowledge,
this
is
first
demonstration
subtype-specific
preclinical
AD.
It
thus
identifies
as
key
regulator
promising
therapeutic
target
for
Communications Biology,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: May 27, 2024
Abstract
Studies
suggest
links
between
diabetes
and
gastrointestinal
(GI)
traits;
however,
their
underlying
biological
mechanisms
remain
unclear.
Here,
we
comprehensively
assess
the
genetic
relationship
type
2
(T2D)
GI
disorders.
Our
study
demonstrates
a
significant
positive
global
correlation
of
T2D
with
peptic
ulcer
disease
(PUD),
irritable
bowel
syndrome
(IBS),
gastritis-duodenitis,
gastroesophageal
reflux
(GERD),
diverticular
disease,
but
not
inflammatory
(IBD).
We
identify
several
local
correlations
(negative
for
–
IBD)
contributing
to
T2D’s
Univariable
multivariable
Mendelian
randomisation
analyses
causal
effects
on
PUD
gastritis-duodenitis
bidirectionally
GERD.
Gene-based
reveal
gene-level
overlap
disorders
shared
genes
reaching
genome-wide
significance.
Pathway-based
implicates
leptin
(T2D
IBD),
thyroid,
interferon,
notch
signalling
IBS),
abnormal
circulating
calcium
PUD),
cardiovascular,
viral,
proinflammatory
(auto)immune-mediated
in
These
findings
support
risk-increasing
(except
implicate
pathways
putative
causality
certain
pairs,
targets
further
investigation.
Frontiers in Neuroscience,
Journal Year:
2024,
Volume and Issue:
18
Published: Feb. 20, 2024
Alzheimer’s
disease
(AD)
is
a
progressive
neurodegenerative
disorder
that
affects
over
50
million
elderly
individuals
worldwide.
Although
the
pathogenesis
of
AD
not
fully
understood,
based
on
current
research,
researchers
are
able
to
identify
potential
biomarker
genes
and
proteins
may
serve
as
effective
targets
against
AD.
This
article
aims
present
comprehensive
overview
recent
advances
in
identification,
with
highlights
use
various
algorithms,
exploration
relevant
biological
processes,
investigation
shared
biomarkers
co-occurring
diseases.
Additionally,
this
includes
statistical
analysis
key
reported
research
literature,
identifies
intersection
AD-related
gene
sets
from
databases
such
AlzGen,
GeneCard,
DisGeNet.
For
these
sets,
besides
enrichment
analysis,
protein–protein
interaction
(PPI)
networks
utilized
central
among
overlapping
genes.
Enrichment
protein
network
tissue-specific
connectedness
GTEx
database
performed
multiple
groups
Our
work
has
laid
foundation
for
better
understanding
molecular
mechanisms
more
accurate
identification
markers.
