Comparative analysis of gonadal hormone receptor expression in the house mouse, meadow vole, and prairie vole brain DOI Creative Commons
Katherine Denney, Melody V. Wu, Simón D. Sun

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 13, 2023

The socially monogamous prairie vole ( Microtus ochrogaster ) and promiscuous meadow pennsylvanicus are closely related, but only voles display long-lasting pair bonds, biparental care, selective aggression towards unfamiliar individuals after bonding. These social behaviors in mammals largely mediated by steroid hormone signaling the behavior network (SBN) of brain. Hormone receptors reproducible markers sex differences that can provide more information than anatomy alone, even be at odds with anatomical dimorphisms. We reasoned associated monogamy may emerge part from unique expression patterns this species, these would similar across males females or laboratory mouse. To obtain insight into developing brain, we assessed estrogen receptor alpha Esr1 ), beta Esr2 androgen Ar within SBN, using situ hybridization postnatal day 14 mice, meadow, voles. found species-specific hippocampus ventromedial hypothalamus, as well species bias principal nucleus bed stria terminalis. findings suggest observed gonadal underlie behaviors.

Language: Английский

Characterization of oxytocin and vasopressin receptors in the Southern giant pouched rat and comparison to other rodents DOI Creative Commons
Angela R. Freeman,

Samanta Arenas,

Danielle N. Lee

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: May 13, 2024

Vasopressin and oxytocin are well known evolutionarily ancient modulators of social behavior. The distribution relative densities vasopressin receptors to modulate the sensitivity these signaling molecules. Comparative work is needed determine which neural networks have been conserved modified over evolutionary time, behaviors commonly modulated by nonapeptide signaling. To this end, we used receptor autoradiography 1a in Southern giant pouched rat (

Language: Английский

Citations

0
Effects of Oxytocin Receptor Agonism on Acquisition and Expression of Pair Bonding in Male Prairie Voles DOI Creative Commons
Andrey E. Ryabinin, Michael Johnson, Jonathan A. Zweig

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 15, 2024

There is much interest in targeting the activity oxytocin system to regulate social bonding. However, studies with exogenous administration of face caveats its low stability, poor brain permeability and insufficient receptor specificity. The use a small-molecule receptor-specific agonist could overcome these caveats. Prior testing potential effects brain-penetrant clinical settings, it important assess how such an would affect bonds animal models. facultatively monogamous prairie voles (

Language: Английский

Citations

0
“Neural correlates of social signaling in rodents: An acoustic perspective” DOI Creative Commons
Dori M. Grijseels, Alena Lemazina, Luciana López‐Jury

et al.

Current Opinion in Neurobiology, Journal Year: 2024, Volume and Issue: 89, P. 102927 - 102927

Published: Oct. 18, 2024

Language: Английский

Citations

0
Comparative analysis of gonadal hormone receptor expression in the house mouse, meadow vole, and prairie vole brain DOI Creative Commons
Katherine Denney, Melody V. Wu, Simón D. Sun

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 13, 2023

The socially monogamous prairie vole ( Microtus ochrogaster ) and promiscuous meadow pennsylvanicus are closely related, but only voles display long-lasting pair bonds, biparental care, selective aggression towards unfamiliar individuals after bonding. These social behaviors in mammals largely mediated by steroid hormone signaling the behavior network (SBN) of brain. Hormone receptors reproducible markers sex differences that can provide more information than anatomy alone, even be at odds with anatomical dimorphisms. We reasoned associated monogamy may emerge part from unique expression patterns this species, these would similar across males females or laboratory mouse. To obtain insight into developing brain, we assessed estrogen receptor alpha Esr1 ), beta Esr2 androgen Ar within SBN, using situ hybridization postnatal day 14 mice, meadow, voles. found species-specific hippocampus ventromedial hypothalamus, as well species bias principal nucleus bed stria terminalis. findings suggest observed gonadal underlie behaviors.

Language: Английский

Citations

1