Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Gastrointestinal Disorders, Journal Year: 2025, Volume and Issue: 7(1), P. 7 - 7
Published: Jan. 15, 2025
The human microbiome, a complex ecosystem of microorganisms residing in and on the body, plays pivotal role regulation wide range physiological processes, including digestion, immune responses, metabolic functions. In recent years, rapidly growing field microbiome-driven therapeutics has garnered significant attention owing to its potential revolutionize healthcare. This review explores evolving landscape microbiome-based therapies, with particular focus gut microbiome implications for both health precision medicine. We highlight advances understanding how microbial communities influence disease pathogenesis treatment outcomes, spanning conditions such as inflammatory bowel (IBD), disorders, neurological diseases, even cancer. article also discusses emerging therapeutic strategies, probiotics, prebiotics, fecal microbiota transplantation (FMT), microbial-based drugs, well challenges associated their clinical implementation. Additionally, we examined integration profiling metagenomic data is advancing medicine, paving way personalized effective treatments. serves comprehensive resource that synthesizes current knowledge, identifies key gaps research, offers insights into future direction therapeutics, thus providing valuable framework clinicians, researchers, policymakers seeking harness microbiomes advance healthcare solutions.
Language: Английский
Citations
4
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: 1880(2), P. 189281 - 189281
Published: Feb. 8, 2025
Language: Английский
Citations
2
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: Nov. 19, 2024
Biomarkers have revolutionized the management of colorectal cancer (CRC), facilitating early detection, prevention, personalized treatment, and minimal residual disease (MRD) monitoring. This review explores current CRC screening strategies emerging biomarker applications. Main body. We summarize landscape non-invasive MRD detection strategies, discuss limitations approaches, highlight promising potential novel solutions. The fecal immunochemical test remained cornerstone screening, but its sensitivity has been improved by assays that combined performance with other stool analytes. However, their for advanced adenomas patient compliance both remain suboptimal. Blood-based tests promise to increase require further refinement compete stool-based tests. ideal scenario involves leveraging blood participation, simultaneously promote stool- endoscopy-based among those who are compliant. Once solely reliant on upfront surgery followed stage pathology-driven adjuvant chemotherapy, treatment II III colon undergone a revolutionary transformation advent testing after surgery. A decade ago, concept using post-surgical instead pathology determine need chemotherapy was disruptive. Today, may be more informative than at diagnosis. Biomarker research is not just improving, bringing transformative change clinical management. Early getting better, improving thanks multi-modality approach, plans becoming reality, future testing.
Language: Английский
Citations
9
Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)
Published: Jan. 29, 2025
Fusobacterium nucleatum is a Gram-negative oncobacterium that associated with colorectal cancer. The molecular mechanisms utilized by F. to promote tumor development have largely focused on adhesin-mediated binding the tissue and pro-inflammatory capacity of nucleatum. However, exact manner in which promotes inflammation microenvironment subsequent promotion remains underexplored. Here, we show both living sterile nucleatum-conditioned medium CXCL8 release from intestinal adenocarcinoma HT-29 cell line. We determined observed effect was ALPK1-dependent HEK293 cells released molecule had characteristics match those ALPK1 ligand ADP-heptose or related heptose phosphates. In addition, not only promoted an environment but also other species such as varium, necrophorum gonidiaformans generated similar effects, indicating phosphate secretion conserved feature genus. By performing transcriptional analysis stimulated cells, found several inflammatory cancer-related pathways be differentially regulated, including DNA mismatch repair genes immune inhibitory receptor PD-L1. Finally, stimulation resulted upregulation These results aid our understanding can affect therapy pave way for future therapeutic approaches.
Language: Английский
Citations
1
Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(11)
Published: Oct. 25, 2024
Lactylation, a recently identified form of protein post-translational modification (PTM), has emerged as key player in cancer biology. The Warburg effect, hallmark tumour metabolism, underscores the significance lactylation progression. By regulating gene transcription and function, facilitates metabolic reprogramming, enabling tumours to adapt nutrient limitations sustain rapid growth. Over past decade, extensive research revealed intricate regulatory network underlying tumours. Large-scale sequencing machine learning have confirmed widespread occurrence sites across proteome. Targeting enzymes or pathways demonstrated promising anti-tumour effects, highlighting therapeutic potential this modification. This review comprehensively explores mechanisms cells microenvironment. We expound on application advanced omics technologies for target identification data modelling within field. Additionally, we summarise existing anti-lactylation drugs discuss their clinical implications. providing comprehensive overview recent advancements, aims stimulate innovative accelerate translation lactylation-based therapies into practice. KEY POINTS: Lactylation significantly influences metabolism regulation, contributing Advanced reveal shows promise enhancing drug efficacy overcoming chemotherapy resistance. outlines implications future directions oncology.
Language: Английский
Citations
6
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 14, 2025
Abstract Understanding microbial-host interactions in the oral cavity is essential for elucidating disease pathogenesis and its systemic implications. In vitro bacteria-host cell coculture models have enabled fundamental studies to characterize bacterial infection host responses a reductionist yet reproducible manner. However, existing fail replicate physiological oxygen gradients critical studying these interactions. Here, we present an asymmetric gas system that simulates microenvironment by maintaining distinct normoxic anaerobic conditions gingival epithelial cells bacteria, respectively. Using Fusobacterium nucleatum , key pathobiont, demonstrate preserves viability supports integrity of telomerase-immortalized keratinocytes. Compared conventional models, this enhanced invasion, elevated intracellular loads, elicited more robust pro-inflammatory responses, including increased secretion CXCL10, IL-6, IL-8. Additionally, model precise evaluation antibiotic efficacy against pathogens. These results underscore utility platform microbial screening therapeutics, offering physiologically relevant approach advance health research. TOC
Language: Английский
Citations
0
Journal of Applied Genetics, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 31, 2025
Endometrial cancer (EC) is the second most frequent gynecological malignancy and sixth common women's worldwide. EC incidence rate increasing rapidly. Apart from classical, we should consider angiogenesis hypoxia-related genes as a reason for manifestation progression. We compared patterns of HIF1A, EPAS1, VEGFA (genes interest - GOIs) mRNA expression in 92 cases. HIF1A levels were higher patients than controls. differed significantly between controls both tumor grades G2 G3, observed positive correlation with grading. post-menopausal to pre-menopausal patients. All GOIs demonstrated strong correlations cases weak A was all only EPAS1 VEGFA. positively correlated Multiple linear regression analyses revealed that menopause, body mass index (BMI), are significant stimulating factors occurrence. after BMI comorbidity number adjustment. The gene-to-gene relation could be seen either diagnostic or therapeutic target EC. Physicians inform about modifiable risk such BMI. Second, more attention paid diagnosing comorbidities older age menopause. These considered designing gene-targeting therapies.
Language: Английский
Citations
0
Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 323 - 323
Published: March 7, 2025
Background: Fusobacterium nucleatum is a pathobiont that plays dual role as both commensal and pathogen. The oral cavity typically harbors this anaerobic, Gram-negative bacterium. At the same time, it closely linked to colorectal cancer due its potential involvement in tumor progression resistance chemotherapy. mechanism by which transforms from pathogen remains unknown. For reason, we investigated of oxidative status an initiatory factor changing bacterium’s pathogenicity profile. Methods: A clinical strain F. subsp. animalis biofilm was exposed different stress levels through varying subinhibitory amounts H2O2. Subsequently, behavior vitro infecting HT-29 cell line. We evaluated bacterial colonization, volatile sulfur compounds production, infected cell’s analyzing HMOX1, pri-miRNA 155, 146a gene expression. Results: colonization rate, dimethyl sulfide 155 all increased when stressed bacteria were used, suggesting predominant pathogenic function these strains. Conclusions: response conditions could potentially explain increase traits existence environmental factors may trigger virulence.
Language: Английский
Citations
0
Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)
Published: March 21, 2025
Language: Английский
Citations
0
Advances in clinical chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0