Diversity of ancestral brainstem noradrenergic neurons across species and multiple biological factors DOI Creative Commons
Michael A. Kelberman, Ellen M. Rodberg, Ehsan Arabzadeh

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract The brainstem region, locus coeruleus (LC), has been remarkably conserved across vertebrates. Evolution woven the LC into wide-ranging neural circuits that influence functions as broad autonomic systems, stress response, nociception, sleep, and high-level cognition among others. Given this conservation, there is a strong possibility activity inherently similar species, furthermore age, sex, brain state similarly species. degree to which homogenous these factors, however, never assessed due small sample size of individual studies. Here, we pool data from 20 laboratories (1,855 neurons) show diversity both intrinsic extrinsic factors such sex state. We use negative binomial regression model compare male monkeys, rats mice sexes were recorded states slices ex vivo or under different anesthetics during wakefulness in . differed complex interactions became more active aging, independent sex. Finally, contrast foundational principle all species express two distinct firing modes (“tonic” “phasic”), discovered great within spontaneous patterns. Different associated with higher incidence some modes. conclude evolutionarily-ancient not conserved. Inherent differences age species-sex-brain have implications for understanding role species-specific naturalistic behavior, well psychiatric disorders, cardiovascular disease, immunology, metabolic disorders.

Language: Английский

Stimulate to Remember? The Effects of Short Burst of Transcutaneous Vagus Nerve Stimulation (taVNS) on Memory Performance and Pupil Dilation DOI Creative Commons
Mareike Ludwig, Matthew J. Betts,

Dorothea Hämmerer

et al.

Psychophysiology, Journal Year: 2025, Volume and Issue: 62(1)

Published: Jan. 1, 2025

ABSTRACT The decline in noradrenergic (NE) locus coeruleus (LC) function aging is thought to be implicated episodic memory decline. Transcutaneous auricular vagus nerve stimulation (taVNS), which supports LC function, might serve preserve or improve aging. However, taVNS effects are generally very heterogeneous, and it currently unclear whether has an effect on memory. In this study, emotional task with negative events involving the LC‐NE system was combined short burst of event‐related (3 s) younger adults ( N = 24). aim investigate taVNS‐induced changes pupil dilation during encoding possible improvements (emotional) performance for early delayed (24 h) recognition. Negative were associated increased better performance. Additionally, real as compared sham no selectively events. Short bursts stimulation, sham, led increase improvement over time, likely due attention‐inducing sensory modulation electrical stimulation.

Language: Английский

Citations

1
Diversity of ancestral brainstem noradrenergic neurons across species and multiple biological factors DOI Creative Commons
Michael A. Kelberman, Ellen M. Rodberg, Ehsan Arabzadeh

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract The brainstem region, locus coeruleus (LC), has been remarkably conserved across vertebrates. Evolution woven the LC into wide-ranging neural circuits that influence functions as broad autonomic systems, stress response, nociception, sleep, and high-level cognition among others. Given this conservation, there is a strong possibility activity inherently similar species, furthermore age, sex, brain state similarly species. degree to which homogenous these factors, however, never assessed due small sample size of individual studies. Here, we pool data from 20 laboratories (1,855 neurons) show diversity both intrinsic extrinsic factors such sex state. We use negative binomial regression model compare male monkeys, rats mice sexes were recorded states slices ex vivo or under different anesthetics during wakefulness in . differed complex interactions became more active aging, independent sex. Finally, contrast foundational principle all species express two distinct firing modes (“tonic” “phasic”), discovered great within spontaneous patterns. Different associated with higher incidence some modes. conclude evolutionarily-ancient not conserved. Inherent differences age species-sex-brain have implications for understanding role species-specific naturalistic behavior, well psychiatric disorders, cardiovascular disease, immunology, metabolic disorders.

Language: Английский

Citations

3