The Role of M6A LncRNA Modification in Papillary Thyroid Cancer DOI Open Access

Michelle S. Klausner,

Caylee A. Greenberg, Kaleb Noruzi

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2833 - 2833

Published: March 21, 2025

Thyroid Cancer (TC) is the most common endocrine cancer, of which papillary thyroid cancer (PTC), a well-differentiated type TC, accounts for 80–90%. Long non-coding RNAs (lncRNAs), comprise non-protein-coding segments genome, have been found to play crucial role in various biological processes, including development. The activity lncRNAs modified through epigenetic modifications, with N6-Methyladenosine (m6A) modifications implicated progression several malignancies. m6A further regulated by modifying enzymes classified as “readers”, writers”, and “erasers”, specific aspects PTC. Recent research has highlighted significance modification regulating expression function associated PTC pathogenesis. Dysregulation this process implicates tumor proliferation, invasion, metastasis, subsequent impact on prognosis. Therefore, understanding interplay between provides valuable insights into molecular mechanisms underlying progression. This narrative review aims explore established prominent pathogenesis seeks clarify these

Language: Английский

IDO1 inhibits ferroptosis by regulating FTO-mediated m6A methylation and SLC7A11 mRNA stability during glioblastoma progression DOI Creative Commons
Qianting Tian,

Guixue Dan,

Xuyan Wang

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 25, 2025

Language: Английский

Citations

2
Therapeutic Potential of FTO Demethylase in Metabolism and Disease Pathways DOI

Chaitanya Sree Somala,

S. Sathyapriya,

Nagaraj Bharathkumar

et al.

The Protein Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Language: Английский

Citations

1
Exploring m6A modifications in gastric cancer: from molecular mechanisms to clinical applications DOI Creative Commons
Penghui Li,

Xiangjie Fang,

Di Huang

et al.

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: Feb. 12, 2025

The significance of m6A modifications in several biological processes has been increasingly recognized, particularly the context cancer. For instance, gastric cancer (GC) have significantly implicated tumor progression, metastasis, and treatment resistance. GC is characterized by differential expression regulators. High writers such as METTL3 WTAP are associated with poor prognosis aggressive clinical features. Conversely, low METTL14 linked to worse outcomes, whereas elevated levels demethylases, FTO ALKBH5, correlate better survival rates. These regulators influence cellular functions, including proliferation, invasion, migration, glycolysis, chemotherapy resistance, thereby affecting growth therapeutic outcomes. assessment modification patterns profiles m6A-related genes hold substantial potential for improving diagnosis GC. In this review, we provide an updated comprehensive summary role GC, emphasizing their molecular mechanisms, significance, translational applications developing novel diagnostic strategies.

Language: Английский

Citations

1
Morin induces autophagy-dependent ferroptosis in colorectal cancer cells by inhibiting the AURKB-UCHL3 interactions DOI
Rui Li, Sha He, Fengxia Wang

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111875 - 111875

Published: May 1, 2025

Language: Английский

Citations

0
The Role of M6A LncRNA Modification in Papillary Thyroid Cancer DOI Open Access

Michelle S. Klausner,

Caylee A. Greenberg, Kaleb Noruzi

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2833 - 2833

Published: March 21, 2025

Thyroid Cancer (TC) is the most common endocrine cancer, of which papillary thyroid cancer (PTC), a well-differentiated type TC, accounts for 80–90%. Long non-coding RNAs (lncRNAs), comprise non-protein-coding segments genome, have been found to play crucial role in various biological processes, including development. The activity lncRNAs modified through epigenetic modifications, with N6-Methyladenosine (m6A) modifications implicated progression several malignancies. m6A further regulated by modifying enzymes classified as “readers”, writers”, and “erasers”, specific aspects PTC. Recent research has highlighted significance modification regulating expression function associated PTC pathogenesis. Dysregulation this process implicates tumor proliferation, invasion, metastasis, subsequent impact on prognosis. Therefore, understanding interplay between provides valuable insights into molecular mechanisms underlying progression. This narrative review aims explore established prominent pathogenesis seeks clarify these

Language: Английский

Citations

0