The role of GOT1 in cancer metabolism DOI Creative Commons
Huan Peng,

Hong-tao Dou,

shu he

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Dec. 24, 2024

GOT1, a cytoplasmic glutamic oxaloacetic transaminase, plays critical role in various metabolic pathways essential for cellular homeostasis and dysregulated metabolism. Recent studies have highlighted the significant plasticity roles of GOT1 reprogramming through participating both classical non-classical glutamine metabolism, glycolytic other pathways. This review summarizes emerging insights on cancer cells emphasizes response to altered metabolism when expression is altered. We how repurpose cell intrinsic their flexibility inhibited delineate molecular mechanisms GOT1’s interaction with specific oncogenes regulators at multiple levels, including transcriptional epigenetic regulation, which govern growth These may provide new directions research novel targets treatment.

Language: Английский

The role of GOT1 in cancer metabolism DOI Creative Commons
Huan Peng,

Hong-tao Dou,

shu he

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Dec. 24, 2024

GOT1, a cytoplasmic glutamic oxaloacetic transaminase, plays critical role in various metabolic pathways essential for cellular homeostasis and dysregulated metabolism. Recent studies have highlighted the significant plasticity roles of GOT1 reprogramming through participating both classical non-classical glutamine metabolism, glycolytic other pathways. This review summarizes emerging insights on cancer cells emphasizes response to altered metabolism when expression is altered. We how repurpose cell intrinsic their flexibility inhibited delineate molecular mechanisms GOT1’s interaction with specific oncogenes regulators at multiple levels, including transcriptional epigenetic regulation, which govern growth These may provide new directions research novel targets treatment.

Language: Английский

Citations

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