Medium from human iPSC-derived primitive macrophages promotes adult cardiomyocyte proliferation and cardiac regeneration DOI Creative Commons
Yi Xiao, Hao Zhang, Xu Liu

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 27, 2025

Heart injury has been characterized by the irreversible loss of cardiomyocytes comprising contractile tissues heart and thus strategies enabling adult cardiomyocyte proliferation are highly desired for treating various diseases. Here, we test ability human induced pluripotent stem cell-derived primitive macrophages (hiPMs) their conditioned medium (hiPM-cm) to promote enhance cardiac regeneration in mice. We find that hiPMs proliferation, which is recapitulated hiPM-cm through activation multiple pro-proliferative pathways, a secreted proteome analysis identifies five proteins participating this activation. Subsequent vivo experiments show promotes Lastly, enhances improves function injured mouse hearts. Together, our study demonstrates efficacy using promoting serve as an innovative treatment disease. Reactivating key post-injury. authors from iPSC-derived induces regeneration.

Language: Английский

Medium from human iPSC-derived primitive macrophages promotes adult cardiomyocyte proliferation and cardiac regeneration DOI Creative Commons
Yi Xiao, Hao Zhang, Xu Liu

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 27, 2025

Heart injury has been characterized by the irreversible loss of cardiomyocytes comprising contractile tissues heart and thus strategies enabling adult cardiomyocyte proliferation are highly desired for treating various diseases. Here, we test ability human induced pluripotent stem cell-derived primitive macrophages (hiPMs) their conditioned medium (hiPM-cm) to promote enhance cardiac regeneration in mice. We find that hiPMs proliferation, which is recapitulated hiPM-cm through activation multiple pro-proliferative pathways, a secreted proteome analysis identifies five proteins participating this activation. Subsequent vivo experiments show promotes Lastly, enhances improves function injured mouse hearts. Together, our study demonstrates efficacy using promoting serve as an innovative treatment disease. Reactivating key post-injury. authors from iPSC-derived induces regeneration.

Language: Английский

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