Radiation Oncology, Journal Year: 2025, Volume and Issue: 20(1)
Published: May 20, 2025
Language: Английский
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 13, 2025
Abstract The lymphatic system, which regulates inflammation and fluid homeostasis, is damaged in various diseases including myocardial infarction (MI) breast‐cancer‐related lymphedema (BCRL). Mounting evidence suggests that restoring tissue drainage clearing excess immune cells by regenerating vessels can aid cardiac repair amelioration. Current treatments primarily address symptoms rather than underlying causes due to a lack of regenerative therapies, highlighting the importance system as promising novel therapeutic target. Here cutting‐edge research on engineered tissues, growth factor cell‐based approaches designed enhance lymphangiogenesis restore function explored. Special focus placed how therapies with potential for immediate reconstruction, originally treating BCRL, be applied MI augment reduce heart failure risk. integration these significantly improve patient outcomes promoting repair, preventing pathological remodeling, offering new avenues managing lymphatic‐associated diseases.
Language: Английский
Citations
1
Advanced Materials Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: April 24, 2025
Abstract Granular hydrogels show great promise in biomedical applications by mimicking the extracellular matrix and fostering a supportive microenvironment for tissue regeneration. This study investigates how tuning granular hydrogel properties influences lymphatic tube formation. Microgels were fabricated using norbornene‐modified hyaluronic acid (NorHA) via pipetting or vortexing 90 s (V90s) 180 (V180s), then assembled into under loose tight packing conditions. These conditions produced gels with varied pore morphologies bulk rheological properties. Lymphatic capillary formation occurred only tightly packed gels, where mechanical converged, highlighting importance of gel morphology over stiffness. V180s samples showed earlier vessel as seen gene protein expression, while pipetted exhibited greater connectivity, forming larger clusters fewer small satellite structures. The also supported lower‐curvature, more linear networks that bridged multiple droplets, likely due to reduced entrapment large voids compared vortexed gels. findings suggest is governed not stiffness but size topology (periodicity). Understanding optimizing these morphological parameters can inform future strategies engineering regenerative medicine.
Language: Английский
Citations
0
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13
Published: May 20, 2025
Biomaterial-assisted stem cell therapies hold immense promise for regenerative medicine, yet clinical translation remains challenging. This review focuses on recent advances and persistent limitations in applying induced pluripotent cells (iPSCs), endothelial colony-forming (ECFCs), multipotent mesenchymal stromal (MSCs), embryonic (ESCs) within engineered microenvironments. We introduce a novel "bottom-up" approach to biomaterial design. first understanding the fundamental biological properties microenvironmental needs of cells, then engineering cell-instructive biomaterials support them. Unlike conventional methods that adapt pre-existing materials, this strategy prioritizes designing from molecular level upward address key challenges, including differentiation variability, incomplete matching iPSCs somatic counterparts, functional maturity derived survival ECFCs/MSCs therapeutic niches. By replicating lineage-specific mechanical, chemical, spatial cues, these tailored enhance fidelity, reprogramming efficiency, integration. paradigm shift passive scaffolds dynamic, platforms bridges critical gaps between laboratory success translation, offering transformative roadmap medicine tissue engineering.
Language: Английский
Citations
0
Radiation Oncology, Journal Year: 2025, Volume and Issue: 20(1)
Published: May 20, 2025
Language: Английский
Citations
0