Lactobacillus johnsonii JERA01 activates macrophages and increases Th-1 T cell population in mouse small intestine DOI Creative Commons
So Yeon Ahn,

Hong-Gu Joo,

Eun‐Ju Ko

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0320946 - e0320946

Published: April 24, 2025

Lactobacillus johnsonii is a commensal bacterium isolated from the vaginal and gastrointestinal tracts of vertebrate hosts, including humans. It potential anti-inflammatory bacterium. As reported in many animal studies, L. supplementation reduces inflammation intestine enhances epithelial barrier. However, this study, we observed immunostimulatory effects heat-killed JERA01 (LJ) on antigen-presenting cells, such as dendritic cells macrophages, mice. LJ pretreatment increased expression maturation markers TNF-α, IL-6, IL-12p40 production bone marrow-derived macrophages (BMDCs BMDMs). Co-culture LJ-pretreated BMDCs or BMDMs with lymphocytes enhanced IFN-γ vitro . Oral (10 8 CFU) induced macrophage infiltration into peritoneal cavity Peyer’s patch at 12-h after administration, resulting an increase population IFN-γ-producing T patch. Our investigation revealed LJ, which activates increases Th-1 cell intestine, implying possibility using immune stimulator.

Language: Английский

Targeting neutrophil dysfunction in acute lung injury: insights from active components of Chinese medicine DOI

Saiya Ye,

Lin Ma, Yayun Chi

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156664 - 156664

Published: March 1, 2025

Language: Английский

Citations

0
Novel β-γ′ type lignans from cultivated Notopterygium incisum and their potential anti-inflammatory activity DOI Creative Commons
Xuelin Zhou, Zhiqiang Niu,

Haifeng Wu

et al.

Industrial Crops and Products, Journal Year: 2025, Volume and Issue: 229, P. 120944 - 120944

Published: April 5, 2025

Language: Английский

Citations

0
Lactobacillus johnsonii JERA01 activates macrophages and increases Th-1 T cell population in mouse small intestine DOI Creative Commons
So Yeon Ahn,

Hong-Gu Joo,

Eun‐Ju Ko

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0320946 - e0320946

Published: April 24, 2025

Lactobacillus johnsonii is a commensal bacterium isolated from the vaginal and gastrointestinal tracts of vertebrate hosts, including humans. It potential anti-inflammatory bacterium. As reported in many animal studies, L. supplementation reduces inflammation intestine enhances epithelial barrier. However, this study, we observed immunostimulatory effects heat-killed JERA01 (LJ) on antigen-presenting cells, such as dendritic cells macrophages, mice. LJ pretreatment increased expression maturation markers TNF-α, IL-6, IL-12p40 production bone marrow-derived macrophages (BMDCs BMDMs). Co-culture LJ-pretreated BMDCs or BMDMs with lymphocytes enhanced IFN-γ vitro . Oral (10 8 CFU) induced macrophage infiltration into peritoneal cavity Peyer’s patch at 12-h after administration, resulting an increase population IFN-γ-producing T patch. Our investigation revealed LJ, which activates increases Th-1 cell intestine, implying possibility using immune stimulator.

Language: Английский

Citations

0