Insights on the Pathogenesis of Mycobacterium abscessus Infection in Patients with Cystic Fibrosis DOI Open Access

Mohamad Hafiz Abdul Basher,

Michal Gur, Michal Meir

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(10), P. 3492 - 3492

Published: May 16, 2025

People with CF (pwCF) have a significant risk for pulmonary infections non-tuberculous mycobacteria (NTM), particularly Mycobacterium abscessus (Mab). Mab is an emerging pathogen, which causes in patients chronic lung diseases, CF; disease leads to progressive dysfunction and increased morbidity mortality. Despite advances care, including CFTR modulators (CFTRm), continues pose therapeutic challenge, long-term medical burden. This review provides insights into the complex host–pathogen interplay of pwCF. It detailed overview bacterial virulence factors, biofilm formation, secretion systems, virulence-associated rough morphotype, antibiotic resistance mechanisms. also summarizes features conferring susceptibility host infections, alongside contribution CF-host environment pathogenesis infection, such as antibiotic-derived microbial selection, within-host mycobacterial evolution, interactions co-pathogens Pseudomonas aeruginosa (PA). Finally, implications novel treatments are discussed, considering interplay.

Language: Английский

Insights on the Pathogenesis of Mycobacterium abscessus Infection in Patients with Cystic Fibrosis DOI Open Access

Mohamad Hafiz Abdul Basher,

Michal Gur, Michal Meir

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(10), P. 3492 - 3492

Published: May 16, 2025

People with CF (pwCF) have a significant risk for pulmonary infections non-tuberculous mycobacteria (NTM), particularly Mycobacterium abscessus (Mab). Mab is an emerging pathogen, which causes in patients chronic lung diseases, CF; disease leads to progressive dysfunction and increased morbidity mortality. Despite advances care, including CFTR modulators (CFTRm), continues pose therapeutic challenge, long-term medical burden. This review provides insights into the complex host–pathogen interplay of pwCF. It detailed overview bacterial virulence factors, biofilm formation, secretion systems, virulence-associated rough morphotype, antibiotic resistance mechanisms. also summarizes features conferring susceptibility host infections, alongside contribution CF-host environment pathogenesis infection, such as antibiotic-derived microbial selection, within-host mycobacterial evolution, interactions co-pathogens Pseudomonas aeruginosa (PA). Finally, implications novel treatments are discussed, considering interplay.

Language: Английский

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