Biofilm-Associated Amyloid Proteins Linked with the Progression of Neurodegenerative Diseases DOI Open Access
Alka Ashok Singh, Fazlurrahman Khan, Minseok Song

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2695 - 2695

Published: March 17, 2025

Biofilm-associated amyloid proteins have emerged as significant contributors to the progression of neurodegenerative diseases, representing a complex intersection microorganisms and human health. The cross-beta sheet structure characteristic amyloids produced by gut-colonizing bacteria remains intact, crucial for resilience biofilms. These exacerbate disorders such Alzheimer’s Parkinson’s cross-seeding amyloidogenic like amyloid-beta α-synuclein, accelerating their misfolding aggregation. Despite molecular chaperones heat shock maintaining protein homeostasis, bacterial can overwhelm them, worsening neuronal damage. Genetic variations in chaperone genes further influence amyloidogenesis neurodegeneration. Persistent infections inflammation compromise blood-brain barrier, allowing inflammatory molecules enter brain, perpetuating cycle gut-brain axis underscores impact dysbiosis gut microbiota on brain function, potentially contributing enhancement biofilm antibiotic resistance functional fibrils complicates treatment landscape. interplay among systems, microbial amyloids, diseases urgent need advanced strategies targeting these pathways attenuate disease progression. Understanding processes that relate biofilm-associated onset neurological is critical diagnosing developing novel strategies.

Language: Английский

Biofilm-Associated Amyloid Proteins Linked with the Progression of Neurodegenerative Diseases DOI Open Access
Alka Ashok Singh, Fazlurrahman Khan, Minseok Song

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2695 - 2695

Published: March 17, 2025

Biofilm-associated amyloid proteins have emerged as significant contributors to the progression of neurodegenerative diseases, representing a complex intersection microorganisms and human health. The cross-beta sheet structure characteristic amyloids produced by gut-colonizing bacteria remains intact, crucial for resilience biofilms. These exacerbate disorders such Alzheimer’s Parkinson’s cross-seeding amyloidogenic like amyloid-beta α-synuclein, accelerating their misfolding aggregation. Despite molecular chaperones heat shock maintaining protein homeostasis, bacterial can overwhelm them, worsening neuronal damage. Genetic variations in chaperone genes further influence amyloidogenesis neurodegeneration. Persistent infections inflammation compromise blood-brain barrier, allowing inflammatory molecules enter brain, perpetuating cycle gut-brain axis underscores impact dysbiosis gut microbiota on brain function, potentially contributing enhancement biofilm antibiotic resistance functional fibrils complicates treatment landscape. interplay among systems, microbial amyloids, diseases urgent need advanced strategies targeting these pathways attenuate disease progression. Understanding processes that relate biofilm-associated onset neurological is critical diagnosing developing novel strategies.

Language: Английский

Citations

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