Integrated Analysis of Differential Expression Profiles of miRNA and mRNA in Gonads of Scatophagus argus Provides New Insights into Sexually Biased Gene Expression DOI Creative Commons
Yaling Lei,

Kai-Zhi Jiao,

Yuanqing Huang

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(11), P. 1564 - 1564

Published: May 27, 2025

The Scatophagus argus (S. argus) is a valuable aquaculture species in southern China, with females exhibiting significantly faster growth rates than males. However, the limited understanding of its sex determination and differentiation mechanisms poses challenges for sex-controlled breeding. MicroRNAs (miRNAs), key post-transcriptional regulators, are known to modulate critical pathways governing across several vertebrates. there currently no research on miRNAs related S. argus. In this study, we analyzed expression profiles miRNA mRNA gonads adult using high-throughput sequencing. Our analysis identified 2210 miRNAs, including 482 differentially expressed (DEMs) between sexes. These DEMs targeted 3340 genes (DEGs), generating 13,773 regulatory interaction pairs. some DEGs was found be either positively or negatively correlated that might regulate them. novel_miR_110/Foxl2, novel_miR_802/Gdf9, novel_miR_1263/Gdf9 show opposing differential trends, whereas sar-miR-143-5p-4/Gsdf, sar-miR-143-5p-5/Gsdf, novel_miR_379/Sox3 consistent trends. relationship gene does not seem conserved among different fish species. This work advances our molecular underlying sexual dimorphism gonadal miRNA–gene interactions may serve as potential targets future sex-control strategies, contributing advancements practices

Language: Английский

Integrated Analysis of Differential Expression Profiles of miRNA and mRNA in Gonads of Scatophagus argus Provides New Insights into Sexually Biased Gene Expression DOI Creative Commons
Yaling Lei,

Kai-Zhi Jiao,

Yuanqing Huang

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(11), P. 1564 - 1564

Published: May 27, 2025

The Scatophagus argus (S. argus) is a valuable aquaculture species in southern China, with females exhibiting significantly faster growth rates than males. However, the limited understanding of its sex determination and differentiation mechanisms poses challenges for sex-controlled breeding. MicroRNAs (miRNAs), key post-transcriptional regulators, are known to modulate critical pathways governing across several vertebrates. there currently no research on miRNAs related S. argus. In this study, we analyzed expression profiles miRNA mRNA gonads adult using high-throughput sequencing. Our analysis identified 2210 miRNAs, including 482 differentially expressed (DEMs) between sexes. These DEMs targeted 3340 genes (DEGs), generating 13,773 regulatory interaction pairs. some DEGs was found be either positively or negatively correlated that might regulate them. novel_miR_110/Foxl2, novel_miR_802/Gdf9, novel_miR_1263/Gdf9 show opposing differential trends, whereas sar-miR-143-5p-4/Gsdf, sar-miR-143-5p-5/Gsdf, novel_miR_379/Sox3 consistent trends. relationship gene does not seem conserved among different fish species. This work advances our molecular underlying sexual dimorphism gonadal miRNA–gene interactions may serve as potential targets future sex-control strategies, contributing advancements practices

Language: Английский

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