Chitosan-based nanostructured biomaterials: Synthesis, properties, and biomedical applications

Advanced Industrial and Engineering Polymer Research, Journal Year: 2023, Volume and Issue: 7(1), P. 79 - 99

Published: July 19, 2023

Chitosan is obtained from chitin, which abundantly found in crustaceans and through various methods. The demineralization, deproteinization, discoloration, deacetylation of chitin produce chitosan consisting D-glucosamine N-acetyl units that are linked β-(1,4)-glycosidic linkages. has gained significant attention the biomedical field due to its unique properties such as abundance, renewability, non-toxic nature, antimicrobial activity, biodegradability, polyfunctionality. One key why it been heavily utilized field. To provide a comprehensive overview chitosan, this review discusses extraction based on source It also delves into chemical modifications nanocomposite development using natural synthetic materials. emphasizes multitude make an excellent choice for wide range applications. mechanisms antibacterial activity factors affecting activity. Additionally, highlights hemocompatibility, antioxidant anti-inflammation, other contribute suitability different applications, including wound dressing materials, drug delivery carriers, biosensing diagnostic devices, bone substitutes, bioimaging. While discussing some limitations concludes with future perspective developing multifunctional chitosan-based nanomaterials could potentially move laboratory clinical trials treating diseases.

Language: Английский

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Recent advances in chitosan-based materials; The synthesis, modifications and biomedical applications

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 321, P. 121318 - 121318

Published: Aug. 23, 2023

Language: Английский

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Advances in chitosan-based drug delivery systems: A comprehensive review for therapeutic applications

European Polymer Journal, Journal Year: 2024, Volume and Issue: 210, P. 112983 - 112983

Published: March 26, 2024

Language: Английский

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Ln‐MOF‐Based Hydrogel Films with Tunable Luminescence and Afterglow Behavior for Visual Detection of Ofloxacin and Anti‐Counterfeiting Applications

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(19)

Published: Jan. 26, 2024

Abstract Highly selective and sensitive quantitative detection of ofloxacin (OFX) at ultralow concentrations in aqueous media development new afterglow materials remains a challenge. Herein, 2D water‐stable lanthanide metal–organic framework (NIIC‐2‐Tb) is proposed, which exhibits high selectivity towards OFX through the luminescence quenching with lowest limit (1.1 × 10 −9 M ) reported to date fast response within 6 s. In addition, luminescent by NIIC‐2‐Tb not affected typical components blood plasma urine. The excellent sensing effect further utilized prepare composite functional carrageenan hydrogel material for rapid meat real time first discovery impressive MOF‐based hydrogels. This study only presents novel Ln‐MOF Ln‐MOF‐based films OFX, but also demonstrates color‐tunable afterglow, expands application anti‐counterfeiting.

Language: Английский

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A Comprehensive Review of Hydrogel-Based Drug Delivery Systems: Classification, Properties, Recent Trends, and Applications

AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 25(4)

Published: March 21, 2024

Language: Английский

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Enhanced antibacterial activity of porous chitosan-based hydrogels crosslinked with gelatin and metal ions

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 29, 2024

Abstract Addressing the increasing drug resistance in pathogenic microbes, a significant threat to public health, calls for development of innovative antibacterial agents with versatile capabilities. To enhance antimicrobial activity non-toxic biomaterials this regard, study focuses on novel, cost-effective chitosan (CS)-based hydrogels, crosslinked using gelatin (GEL), formaldehyde, and metallic salts (Ag + , Cu 2+ Zn ). These hydrogels are formed by mixing CS GEL creating iminium ion crosslinks without hazardous crosslinkers. Characterization techniques like FTIR, XRD, FESEM, EDX, rheological tests were employed. FTIR analysis showed metal ions binding amino hydroxyl groups CS, enhancing hydrogelation. FESEM revealed that freeze-dried possess crosslinked, porous structure influenced various ions. Antibacterial testing against gram-negative gram-positive bacteria demonstrated bacterial growth inhibition. CS-based containing reduced MIC MBC values Staphylococcus aureus (0.5, 8, 16 µg/mL) Escherichia coli (1, 16, 8 CS-g-GEL-Ag CS-g-GEL-Cu CS-g-GEL-Zn . MTT assay results confirmed high biocompatibility (84.27%, 85.24%, 84.96% viability at 10 towards HFF-1 cells over 48 h. Therefore, due their nature, these promising applications.

Language: Английский

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Recent Advancements in Chitosan-Based Biomaterials for Wound Healing

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(2), P. 45 - 45

Published: Jan. 30, 2025

Chitosan is a positively charged natural polymer with several properties conducive to wound-healing applications, such as biodegradability, structural integrity, hydrophilicity, adhesiveness tissue, and bacteriostatic potential. Along other mechanical properties, some of the discussed in this review are antibacterial mucoadhesive biocompatibility, high fluid absorption capacity, anti-inflammatory response. forms stable complexes oppositely polymers, arising from electrostatic interactions between (+) amino groups chitosan (−) polymers. These polyelectrolyte (PECs) can be manufactured using various materials methods, which brings diversity formulations that optimized for specific wound healing well applications. For example, chitosan-based PEC made into dressings/films, hydrogels, membranes. There pros cons associated manufacturing dressings; instance, layer-by-layer casting technique optimize nanoparticle release affect strength due formation heterostructure. Furthermore, chitosan’s molecular weight degree deacetylation, nature negatively biomaterial it cross-linked, major factors govern biodegradation kinetics dressing. The use care products forecasted drive growth global market, expected increase by approximately 14.3% within next decade. This driven chitoderm-containing ointments, provide scaffolding skin cell regeneration. Despite significant advancements, there remains critical gap translating biomaterials research clinical

Language: Английский

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Chitosan-Based Smart Biomaterials for Biomedical Applications: Progress and Perspectives

ACS Biomaterials Science & Engineering, Journal Year: 2023, Volume and Issue: 9(6), P. 3084 - 3115

Published: May 13, 2023

Over the past decade, smart and functional biomaterials have escalated as one of most rapidly emerging fields in life sciences because performance could be improved by careful consideration their interaction response with living systems. Thus, chitosan play a crucial role this frontier field it possesses many beneficial properties, especially biomedical such excellent biodegradability, hemostatic antibacterial activity, antioxidant biocompatibility, low toxicity. Furthermore, is versatile biopolymer due to its polycationic nature reactive groups that allow polymer form interesting structures or modified various ways suit targeted applications. In review, we provide an up-to-date development chitosan-based nanoparticles, hydrogels, nanofibers, films, well application field. This review also highlights several strategies enhance biomaterial for fast growing applications drug delivery systems, bone scaffolds, wound healing, dentistry.

Language: Английский

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Decontamination of Congo red dye from aqueous solution using nanoclay/chitosan-graft-gelatin nanocomposite hydrogel

Journal of Molecular Liquids, Journal Year: 2023, Volume and Issue: 395, P. 123839 - 123839

Published: Dec. 21, 2023

Language: Английский

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Preparation of imidazole acids grafted chitosan with enhanced antioxidant, antibacterial and antitumor activities

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 315, P. 120978 - 120978

Published: May 5, 2023

Language: Английский

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