Expanding the Horizon of Natural Products: The Role of Starter Units in Nonribosomal Lipopeptide Biosynthesis DOI
Lin Zhong, Seenivasan Boopathi,

Xingyan Wang

et al.

ACS Synthetic Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Nonribosomal lipopeptides (NRLPs) are structurally complex natural products that play crucial ecological and biological roles. They also valuable sources lead structures for developing new pharmaceuticals. These compounds typically synthesized using a molecular assembly machinery known as nonribosomal peptide synthetases (NRPSs) or hybrid polyketide synthases-NRPSs. Unlike conventional NRPS, NRLPs characterized by starter module loads lipid chains substrate synthesis pathway supplies the necessary substrates during initiation stages. Unique critical determinants of activity NRLPs. Therefore, modifying these through combinatorial biosynthesis holds great promise unlocking their full therapeutic potential. Herein, we use term "Starter Unit" to refer initial modules lipoinitiation involved in chain process This Review provides comprehensive summary recent advances units offers insights into future directions further development.

Language: Английский

Expanding the Horizon of Natural Products: The Role of Starter Units in Nonribosomal Lipopeptide Biosynthesis DOI
Lin Zhong, Seenivasan Boopathi,

Xingyan Wang

et al.

ACS Synthetic Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Nonribosomal lipopeptides (NRLPs) are structurally complex natural products that play crucial ecological and biological roles. They also valuable sources lead structures for developing new pharmaceuticals. These compounds typically synthesized using a molecular assembly machinery known as nonribosomal peptide synthetases (NRPSs) or hybrid polyketide synthases-NRPSs. Unlike conventional NRPS, NRLPs characterized by starter module loads lipid chains substrate synthesis pathway supplies the necessary substrates during initiation stages. Unique critical determinants of activity NRLPs. Therefore, modifying these through combinatorial biosynthesis holds great promise unlocking their full therapeutic potential. Herein, we use term "Starter Unit" to refer initial modules lipoinitiation involved in chain process This Review provides comprehensive summary recent advances units offers insights into future directions further development.

Language: Английский

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