The Journal of Physiology,
Journal Year:
2022,
Volume and Issue:
600(21), P. 4677 - 4693
Published: Sept. 9, 2022
Abstract
Ketogenic
diets
(KDs)
are
a
popular
tool
used
for
weight
management.
Studies
in
mice
have
demonstrated
that
KDs
reduce
food
intake,
increase
energy
expenditure
and
cause
loss.
These
studies
were
completed
at
room
temperature,
condition
below
the
animal's
thermal
neutral
zone
which
induces
stress.
As
intake
sensitive
to
environmental
temperature
it
is
not
clear
if
KD
would
exert
same
beneficial
effects
under
conditions.
Adherence
restrictive
poor
consequently
important
examine
effects,
underlying
mechanisms,
of
cycling
from
ketogenic
an
obesogenic
diet.
The
purpose
current
study
was
determine
housing
impacted
obese
mechanisms
driving
KD‐induced
loss
reverse
when
switched
high
fat
We
demonstrate
reductions
increases
expenditure,
improvements
glucose
homeostasis
dependent
upon
temperature.
seems
be
largely
explained
by
caloric
while
back
diet
following
period
feeding
leads
hyperphagia‐induced
gain.
Collectively,
our
results
suggest
prior
findings
with
fed
likely
artifact
how
housed
initial
changes
transitioning
or
on
intake.
image
Key
points
rodents
Prior
preclinical
been
stress
limits
clinical
translatability
Here
diet‐induced
similar
neutrality
appear
explain
large
degree
Similarly,
switching
hyperphagia‐mediated
gain
Molecular Metabolism,
Journal Year:
2023,
Volume and Issue:
71, P. 101699 - 101699
Published: Feb. 27, 2023
Physical
activity
is
a
major
component
of
total
energy
expenditure
(TEE)
that
exhibits
extreme
variability
in
mice.
Our
objective
was
to
construct
general,
physiology-based
model
TEE
accurately
quantify
the
cost
physical
activity.
Spontaneous
home
cage
activity,
body
temperature,
TEE,
and
intake
were
measured
with
frequent
sampling.
The
modeled
considering
six
contributors
(basal
metabolic
rate,
thermic
effect
food,
cold
induced
thermogenesis,
weight).
An
ambient
temperature
35
°C
required
remove
contribution
from
thermogenesis.
Basal
rate
adjusted
for
using
Q10
coefficient.
We
developed
robustly
explains
70–80%
variance
at
while
fitting
only
two
parameters,
basal
mass-specific
per
unit
which
averaged
60
cal/km/g
weight.
In
Ucp1−/−
mice
elevated
by
60%,
indicating
inefficiency
increased
muscle
diurnal
rhythm
quantitatively
explained
combined
differences
intake.
Incorporating
into
human
measurements
significantly
reduced
inter-individual
variation.
allows
quantifying
While
applied
here
mice,
should
be
generally
valid
across
species.
Due
we
suggest
corrected
reference
including
humans.
Having
an
accurate
mechanistic
dissection
disorders
homeostasis,
obesity.
National Science Review,
Journal Year:
2023,
Volume and Issue:
10(10)
Published: July 27, 2023
Host
phylogeny
and
environment
have
all
been
implicated
in
shaping
the
gut
microbiota
host
metabolic
traits
of
mammals.
However,
few
studies
evaluated
phylogeny-associated
microbial
assembly
plasticity
concurrently,
their
relationships
on
both
short-term
evolutionary
timescales.
We
report
that
branching
order
a
dendrogram
was
nearly
congruent
with
phylogenetic
seven
rodent
species,
this
pattern
phylosymbiosis
intact
after
diverse
laboratory
manipulations.
Laboratory
rearing,
diet
or
air
temperature
(Ta)
acclimation
induced
alterations
communities,
but
could
not
override
community
assembly.
A
simulative
heatwave
reduced
core
diversity
by
26%
these
led
to
an
unmatched
relationship
between
phenotypes
desert
species.
Moreover,
similarity
across
species
at
different
Tas
correlated
distance.
These
data
demonstrated
showed
strong
concordance
may
be
shaped
environmental
variables,
whereas
did
seem
linked
phylogeny.
Journal of Experimental Zoology Part A Ecological and Integrative Physiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 16, 2025
ABSTRACT
An
animal's
body
mass
is
said
to
be
indirectly
related
its
rate
of
heat
loss;
that
is,
smaller
animals
with
higher
surface
area
volume
tend
lose
faster
than
larger
animals.
Thus,
thermoregulation
should
size,
however,
generalizable
patterns
are
still
unclear.
Domestic
dogs
a
diverse
species
endothermic
mammals,
including
44‐fold
difference
in
size.
Previous
work
sedentary
has
determined
size
and
other
morphological
variables
predict
the
exercising
pet
dogs.
Here,
we
aimed
address
three
questions:
(1)
whether
thermoregulatory
differences
domestic
across
seasons
dictated
strictly
by
external
environmental
temperatures
or
if
individual
thermal
acclimation
affected
seasonal
temperature
variation,
even
indoors;
(2)
athleticism
(or
training
experience)
affects
changes
dogs,
as
it
does
humans;
(3)
genetic
basis.
We
obtained
tympanic
membrane
(T
ear
)
images
measure
change
eyes,
mouth,
nose
athletic
following
an
indoor
agility
trial.
Additionally,
used
image
analysis
determine
morphology
differences.
found
play
strong
role
winter
trials
mouth
p
=
0.017,
T
0.052)
but
less
determinate
summer
trials.
distinct
between
summer.
Particularly,
coat
length
may
different
roles
seasons.
rates
differ
interaction
experience
(
0.044),
suggesting
depend
on
relative
athleticism.
Lastly,
important
predictors
rate,
such
GORAB
IGF1,
well
others
exert
influence
over
mitochondrial
function,
characteristics.
These
markers
indicate
similar
our
whole‐animal
physiological
results.
Overall,
data
suggest
demonstrate
seasons,
size‐related
genes
associated
Journal of Zoology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 17, 2025
Abstract
The
phenotypic
plasticity
of
the
digestive
system
is
important
to
cope
with
variations
in
food
quality
for
wild
small
mammals,
particular
lactating
females
because
they
must
increase
intake
meet
highest
energy
requirements
offspring.
This
study
aimed
investigate
budget
and
reproductive
performance
striped
hamsters
(
Cricetulus
barabensis
)
fed
on
a
high‐fiber
or
high‐fat
diet
across
lactation.
Body
mass,
intake,
resting
metabolic
rate
(RMR),
milk
output
(MEO),
litter
size
mass
were
measured
at
peak
body
composition,
enzymes
activity,
as
well
hypothalamus‐driven
gene
expression
relating
orexigenic
anorexigenic
neuropeptides
was
determined
weaning.
lactation
not
significantly
changed
diet,
while
it
decreased
those
compared
control
diet.
did
change
RMR,
but
MEO,
had
smaller
litters
lower
masses.
larger
stomach,
large
intestine,
caecum,
parallel
increases
maltase
aminopeptidase
these
show
significant
changes
amylase,
lipase,
lactase,
chymotrypsin
mRNA
AgRP
increased,
POMC
ones.
group
vary
from
almost
all
parameters.
These
findings
suggest
that
adaptive
modulations
enzyme
activity
may
be
maximized
lactation,
creating
hard
limitation
SusEI
response
which
independent
either
.
