Omics metabolism tools in antiaging drug discovery

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 209 - 225

Published: Jan. 1, 2025

Language: Английский

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The art of war: burning stores to fuel anti-viral immunity

Nature Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

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Glycation metabolites predict incident age-related comorbidities and mortality in older people with HIV

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Abstract Glycation is a class of modifications arising from non-enzymatic reactions reducing sugars with proteins, lipids, and/or DNA, generating advanced glycation end-products (AGEs). AGEs are linked to many age-related comorbidities. In response HIV-1 infection, activated T-cells and macrophages shift their predominate metabolism oxidative phosphorylation glycolysis. Increased glycolytic flux enhances AGE formation, which may increase this prospective, multicenter cohort study antiretroviral therapy treated people HIV, we explored predictive associations by baseline plasma concentrations corresponding detoxification metabolites, incident comorbidities mortality. included dicarbonyl sugars: 3-deoxyglucosone, glyoxal, methylglyoxal. Methylglyoxal-derived metabolites carboxyethyl-arginine, carboxyethyl-lysine, methylglyoxal hydroimidazolone-1. Detoxification reduced oxidized glutathione, the glyoxalase cycle products lactoyl-glutathione lactoyl-Lysine modified proteins. Plasma was collected at entry, in fasting state, assayed liquid chromatography-mass spectroscopy. Incident clinical outcomes diabetes, chronic kidney disease, hypertension, neurocognitive impairment, peripheral neuropathy, frailty, fractures, recurrent falls, all-cause Among 376 participants, higher derived predicted increased risks while 3-deoxyglucosone an risk neuropathy. By contrast, or lactoyl-glutathione, proteins lower These findings support growing experimental evidence potential mitigate declines interventions that reduce glutathione.

Language: Английский

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Investigating how dengue virus-induced metabolic changes affect the host immune response and how to develop Immunomodulatory strategies

Virology Journal, Journal Year: 2025, Volume and Issue: 22(1)

Published: April 25, 2025

Dengue virus (DENV) infection imposes a significant global health burden, driven by its ability to manipulate host cellular processes facilitate replication and evade immune defenses. This review explores the complex interplay between DENV, immunometabolism, signaling pathways. DENV induces metabolic reprogramming, including glycolytic upregulation, lipid droplet utilization through lipophagy, alterations in amino acid metabolism, fulfill energy biosynthetic needs. The also disrupts mitochondrial dynamics, leading increased reactive oxygen species (ROS) production, which modulates responses but may contribute oxidative stress severe pathology. Concurrently, hijacks pathways, PI3K/Akt, NF-κB, JAK/STAT, suppress apoptosis, type I interferon responses, drive pro-inflammatory cytokine production. these pathways highlights dual role of processes: enabling viral while activating antiviral responses. examines potential therapeutic strategies targeting combat infection, glycolysis inhibitors, metabolism modulators, host-directed therapies. While progress has been made understanding DENV-induced further research is needed elucidate precise molecular mechanisms translate findings into clinical applications. study underscores importance integrating insights identify novel targets against related flaviviruses, addressing critical need for effective interventions.

Language: Английский

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Systems analysis unravels a common rural-urban gradient in immunological profile, function, and metabolic dependencies

Science Advances, Journal Year: 2025, Volume and Issue: 11(18)

Published: May 1, 2025

Urbanization affects environmental exposures and lifestyle, shaping immune system variation influencing disease susceptibility vaccine responses. Here, we present systems analysis of profiles across the rural-urban gradient, comparing rural urban Senegalese with Dutch individuals. By integrating single-cell phenotyping, metabolic profiling, functional analysis, reveal a trajectory remodeling along gradient. This includes enrichment proinflammatory CD11c+ B cells associated altered IgG Fc glycosylation, adaptive NK reduced responsiveness to accessory cytokines, CD161+CD4+T enhanced cytokine production in settings. Metabolic perturbation studies demonstrated distinct dependencies on glycolysis, pentose phosphate pathway, fatty acid synthesis for cellular responses populations. We validate core signatures an independent Indonesian cohort, suggesting shared immunological adaptations urbanization ancestries geographical areas. Our findings provide insights into function understudied

Language: Английский

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