Decreased mitochondrial‐related gene expression in adipose tissue after acute sprint exercise in humans: A pilot study

Physiological Reports, Journal Year: 2024, Volume and Issue: 12(20)

Published: Oct. 1, 2024

Abstract The aim was to examine the acute effects of sprint exercise (SIT) on global gene expression in subcutaneous adipose tissue (AT) healthy subjects, enhance understanding how SIT influences body weight regulation. hypothesis that upregulates genes involved mitochondrial function and fat metabolism. A total 15 subjects performed three 30‐s all‐out sprints (SIT). Samples were collected from AT, skeletal muscle (SM) blood (brachial artery a AT vein) up min after last sprint. Results showed markers oxidative stress, such as purines hypoxanthine, xanthine uric acid, increased markedly by both vein. Purines also SM tissue. Differential analysis indicated decrease signaling for mitochondrial‐related pathways, including phosphorylation, electron transport, ATP synthesis, heat production uncoupling proteins, well fatty acid beta oxidation. This downregulation related metabolism suggests an early‐stage inhibition mitochondria, potentially protective mechanism against SIT‐induced stress.

Language: Английский

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Intricacies and obscurities of non-shivering thermogenesis

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Language: Английский

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Review: Feed efficiency and metabolic flexibility in livestock

animal, Journal Year: 2024, Volume and Issue: 19(1), P. 101376 - 101376

Published: Nov. 17, 2024

Language: Английский

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Precision medicine in diabetes care

Current Opinion in Endocrinology Diabetes and Obesity, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

This review highlights emerging evidence supporting the premise of precision diabetes care including but not limited to monogenic and discuss potential opportunities, challenges, limitations for clinical adoption.

Language: Английский

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