Circadian disruption in cancer and regulation of cancer stem cells by circadian clock genes: An updated review DOI Creative Commons
Yiling Zhang, Qiang Zhang, Rundong Liu

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: unknown, P. 217391 - 217391

Published: Dec. 1, 2024

Circadian rhythm, regulated by a time keeping system termed as the circadian clock, is important for many biological processes in eukaryotes. Disordered rhythm implicated different human diseases, including cardiovascular disease, neurologic metabolic disorders, and cancer. The stem like-cancer cells (or cancer cells, CSCs) are proposed to stand at top of heterogeneous hierarchy solid tumors, which responsible tumor initiation, development, therapy resistance metastasis. Emerging evidence has shown that clock genes potentially regulate stemness features CSCs several malignant systems, leukemia, glioblastoma, breast cancer, colorectal prostate chronotherapies targeting therefore therapeutic potentials treating malignancies. In this review, we have summarized our current knowledge gene regulation normal stem/progenitor cells. Moreover, provided linking dysregulations development. Importantly, listed potential mechanisms underlying CSCs. Finally, offered attempts chronotherapy Elucidating molecular will provide us novel direction development therapeutics target

Language: Английский

Exercise ameliorates osteopenia in mice via intestinal microbial-mediated bile acid metabolism pathway DOI Creative Commons
Congcong Yu,

Rongtai Sun,

Wentao Yang

et al.

Theranostics, Journal Year: 2025, Volume and Issue: 15(5), P. 1741 - 1759

Published: Jan. 2, 2025

Rationale: Physical exercise is essential for skeletal integrity and bone health. The gut microbiome, as a pivotal modulator of overall physiologic states, closely associated with homeostasis metabolism. However, the potential role intestinal microbiota in exercise-mediated gain remains unclear. Methods: We conducted depletion fecal transplantation (FMT) ovariectomy (OVX) mice aged to investigate whether transfer ecological traits could confer exercise-induced protective effects. study analyzed metabolic profiles via 16S rRNA gene sequencing LC-MS untargeted metabolomics identify key microbial communities metabolites responsible protection. Transcriptome RNA interference were employed explore molecular mechanisms. Results: found that hindered osteogenic benefits exercise, FMT from exercised osteoporotic effectively mitigated osteopenia. Comprehensive profiling microbiome metabolome revealed exercise-matched reshaped microecology landscape. Notably, alterations bile acid metabolism, specifically enrichment taurine ursodeoxycholic acid, mediated effects on mass. Mechanistically, activated apelin signaling pathway restored bone-fat balance recipient MSCs. Conclusion: Our underscored important microbiota-metabolic axis gain, heralding breakthrough treatment osteoporosis.

Language: Английский

Citations

0
In vitro dynamics of rumen microbiota and fermentation profiles with Antler growth of Sika deer DOI Creative Commons
Songze Li, Shaoying Wang,

Yuhang Zhu

et al.

Microbiology Spectrum, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

ABSTRACT The rumen microbiota plays a vital role in the nutrient metabolism affecting growth of velvet antler. However, fermentation patterns and dynamics across stages antler remain largely unexplored. Here, we employed an vitro approach to assess parameters microbial composition liquid sika deer during early (EG), metaphase (MG), fast (FG) phases . Our findings indicated that levels short-chain fatty acids (SCFAs), ammonia nitrogen, gas production increased over time all three groups. concentrations total SCFAs, production, along with proportions butyrate, isobutyrate, isovalerate, were markedly higher MG FG groups compared EG group. Principal coordinate analysis highlighted significant variations communities among EG, MG, process. abundances Stomatobaculum Blautia time, whereas Bacteroides , Lawsonibacter Sporobacter Papillibacter Butyricicoccus Succiniclasticum exhibited or than group after 24 hours fermentation. Co-occurrence network uncovered positive correlations between butyrate butyrate-producing bacteria ( Butyrivibrio ) Additionally, there proteolytic Clostridium Roseburia branched-chain volatile These shed light on within different periods IMPORTANCE Velvet antlers are distinctive rapidly growing organs hold value traditional medicine. Through analysis, our study characterized metabolites throughout phase. We identified distinct at various points observed shifts paralleled development. suggest potentially pivotal for these facilitating process antlers.

Language: Английский

Citations

0
Mechanical Loading Induces NRF2 Nuclear Translocation to Epigenetically Remodel Oxidative Stress Defense in Osteocytes DOI Creative Commons
Yue Guo, Jing Zhang,

Luyu Gong

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 346 - 346

Published: March 15, 2025

The mechano-responsiveness of osteocytes is critical for maintaining bone health and associated with a reduced oxidative stress defense, yet the precise molecular mechanisms remain incompletely understood. Here, we address gap by investigating epigenetic reprogramming that drives osteocyte responses to mechanical loading. We found overall remodeling antioxidant response under loading identified NRF2, key transcription factor in response, which plays vital role osteocytes. results showed enhanced NRF2 protein stability, promoted its nuclear translocation, activated osteocyte-specific transcriptional programs. In contrast, pharmacological stabilization failed fully replicate these effects, underscoring unique stimuli modulating activity function. Our findings highlight potential therapeutic limitations NRF2-stabilizing drugs suggest combining approaches interventions could offer more effective treatments maintain homeostasis.

Language: Английский

Citations

0
Integrating cancer medicine into metabolic rhythms DOI
Keyu Su,

Deshun Zeng,

Weiru Zhang

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Exercise alleviates osteoporosis by regulating the secretion of the Senescent Associated Secretory Phenotype DOI

Weng Kaihong,

Yuting He, Weng Xi-quan

et al.

Bone, Journal Year: 2025, Volume and Issue: unknown, P. 117485 - 117485

Published: April 1, 2025

Language: Английский

Citations

0
Exercise‐Mediated Mechanical Stress Promotes Osteogenic Differentiation of BMSCs Through Upregulation of Lactylation via the IER3/LDHB Axis DOI

Shuo Dai,

Zhe Chen,

Xingbang Liu

et al.

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(8)

Published: April 17, 2025

Despite decades of research, senile osteoporosis still lacks effective treatments. Exercise-mediated mechanical loading enhances bone density, strength, and microstructure, while lack exercise leads to significant loss. In this study, we used treadmill tail-suspension mouse models explore the effects on metabolism. We found that osteoblast signal transduction factors activity Immediate Early Response 3 (IER3) protein aligned with exercise-induced changes in mass metabolic levels. Mechanical forces were shown enhance IER3 activity, which is associated osteogenic differentiation marrow mesenchymal stem cells (BMSCs), as demonstrated by vitro experiments using Cell Tank Uniaxial Retraction Stretching System. Conversely, downregulation expression inhibited force-induced osteoblastic differentiation. Interestingly, stress-induced increases lactate content lactylation levels BMSCs blocked when was inhibited. Mass spectrometry analysis identified L-lactate dehydrogenase B chain (LDHB) a downstream target IER3, further confirming critical role exercise-mediated metabolism summary, study highlights maintaining homeostasis via metabolism, suggesting could serve potential therapeutic for osteoporosis.

Language: Английский

Citations

0
Effects of moderate intensity exercise on liver metabolism in mice based on multi-omics analysis DOI Creative Commons
Fang Wang, Wan-Yu Wu,

Xuejia He

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 28, 2024

Physical exercise is beneficial to keep physical and mental health. The molecular mechanisms underlying are still worth exploring. healthy adult mice after six weeks of moderate-intensity (experimental group) sedentary (control were used perform transcriptomic, proteomic, lactylation modification, metabolomics analysis. In addition, gene sets related hypoxia, glycolysis, fatty acid metabolism aid in the screening hub genes. mMCP-counter was employed evaluate infiltration immune cells murine liver tissues. Transcriptomics analysis revealed 82 intersection genes metabolism. Proteomics modification identified 577 proteins 141 differentially proteins. By overlapping with expressed proteins, three (Aldoa, Acsl1, Hadhb) obtained. a decreased score for monocytes/macrophages an increased endothelial experimental group. Then, 459 metabolites positive mode 181 negative identified. "Metabolic pathways" (mmu01100) common pathway between genes-enriched pathways metabolites-enriched pathways. These findings highlight pivotal roles glycolysis under context chronic exercise.

Language: Английский

Citations

1
Anti-aging therapeutics for the musculoskeletal and cardiovascular systems: The role of regular exercise DOI
Wen-Hao Zhang, Wei Zhou, Zhiwen Luo

et al.

The Innovation Medicine, Journal Year: 2024, Volume and Issue: 2(3), P. 100085 - 100085

Published: Jan. 1, 2024

Language: Английский

Citations

0
Circadian disruption in cancer and regulation of cancer stem cells by circadian clock genes: An updated review DOI Creative Commons
Yiling Zhang, Qiang Zhang, Rundong Liu

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: unknown, P. 217391 - 217391

Published: Dec. 1, 2024

Circadian rhythm, regulated by a time keeping system termed as the circadian clock, is important for many biological processes in eukaryotes. Disordered rhythm implicated different human diseases, including cardiovascular disease, neurologic metabolic disorders, and cancer. The stem like-cancer cells (or cancer cells, CSCs) are proposed to stand at top of heterogeneous hierarchy solid tumors, which responsible tumor initiation, development, therapy resistance metastasis. Emerging evidence has shown that clock genes potentially regulate stemness features CSCs several malignant systems, leukemia, glioblastoma, breast cancer, colorectal prostate chronotherapies targeting therefore therapeutic potentials treating malignancies. In this review, we have summarized our current knowledge gene regulation normal stem/progenitor cells. Moreover, provided linking dysregulations development. Importantly, listed potential mechanisms underlying CSCs. Finally, offered attempts chronotherapy Elucidating molecular will provide us novel direction development therapeutics target

Language: Английский

Citations

0