Mitochondria are absent from microglial processes performing surveillance, chemotaxis, and phagocytic engulfment DOI Creative Commons
Alicia N. Pietramale, Xhoela Bame, Megan Doty

et al.

Published: Oct. 18, 2024

Microglia continually surveil the brain allowing for rapid detection of tissue damage or infection. Microglial metabolism is linked to homeostasis, yet how mitochondria are subcellularly partitioned in microglia and dynamically reorganize during surveillance, injury responses, phagocytic engulfment intact not known. Here, we performed intravital imaging mitochondria, revealing that microglial processes diverge, with some containing multiple while others completely void. engage minute-to-minute surveillance typically do have mitochondria. Moreover, unlike process mitochondrial motility does change animal anesthesia. Likewise, acutely chemoattract a lesion site initially neuron undergoing programmed cell death contain Rather, delayed arrival into responding processes. Thus, there subcellular heterogeneity partitioning asymmetry between localization acute responses.

Language: Английский

The foam cell-derived exosomes exacerbate ischemic white matter injury via transmitting metabolic defects to microglia DOI
Hang Zhang, Luo‐Qi Zhou, Sheng Yang

et al.

Cell Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Mitochondria are absent from microglial processes performing surveillance, chemotaxis, and phagocytic engulfment DOI Creative Commons
Alicia N. Pietramale, Xhoela Bame, Megan Doty

et al.

Published: Oct. 18, 2024

Microglia continually surveil the brain allowing for rapid detection of tissue damage or infection. Microglial metabolism is linked to homeostasis, yet how mitochondria are subcellularly partitioned in microglia and dynamically reorganize during surveillance, injury responses, phagocytic engulfment intact not known. Here, we performed intravital imaging mitochondria, revealing that microglial processes diverge, with some containing multiple while others completely void. engage minute-to-minute surveillance typically do have mitochondria. Moreover, unlike process mitochondrial motility does change animal anesthesia. Likewise, acutely chemoattract a lesion site initially neuron undergoing programmed cell death contain Rather, delayed arrival into responding processes. Thus, there subcellular heterogeneity partitioning asymmetry between localization acute responses.

Language: Английский

Citations

0