Malnutrition exacerbating neuropsychiatric symptoms on the Alzheimer's continuum is relevant to the cAMP signaling pathway: Human and mouse studies

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Abstract INTRODUCTION Malnutrition correlates with neuropsychiatric symptoms (NPSs) in Alzheimer's disease (AD); however, the potential mechanism underlying this association remains unclear. METHODS Baseline and longitudinal associations of nutritional status NPSs were analyzed 374 patients on AD continuum 61 healthy controls. Serum biomarkers, behavioral tests, cerebral neurotransmitters, differentially gene expression evaluated standard malnourished diet–fed transgenic APPswe/PSEN1dE9 (APP/PS1) mice. RESULTS Poor increased blood flow midbrain striatum associated severe general subtypes, especially depression, anxiety, apathy. APP/PS1 mice fed a diet showed poor status, depression‐ anxiety‐like behaviors, altered neurotransmitter levels, downregulated c‐Fos striatum; these suppressed cyclic adenosine monophosphate (cAMP) signaling pathway. DISCUSSION exacerbating is relevant to cAMP pathway striatum, suggesting for targeted interventions mitigate continuum. Highlights linked specific symptom (NPS) deterioration. affects NPSs, usually involving striatum. Malnourished induces behaviors exacerbates

Language: Английский

---

The dual action of basal forebrain in feeding regulation

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(9), P. 1653 - 1654

Published: Aug. 7, 2024

Language: Английский

---

Neurons in the diagonal band of Broca moderate food intake

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: 20(11), P. 632 - 632

Published: Aug. 29, 2024

Language: Английский

---