Qingre Sanjie Formula alleviates atherosclerosis by promoting LXR-α/ABCG5/G8-mediated reverse cholesterol transport and bile acid synthesis
Xiao Li,
No information about this author
Xianglong Huang,
No information about this author
K.H. Song
No information about this author
et al.
Phytomedicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 156691 - 156691
Published: March 1, 2025
Language: Английский
Lethal toxicity of metformin on zebrafish during early embryonic development by multi-omics analysis
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: April 2, 2025
Metformin
is
an
antidiabetic
drug
used
in
type
2
diabetes
as
well
indicators
polycystic
ovary
syndrome
(PCOS)
and
cancer.
Due
to
their
increase
popularity,
high
amounts
of
metformin
are
being
released
into
aquatic
environments.
However,
the
toxic
effect
on
embryonic
development
organisms
remains
limited.
Therefore,
this
study
aimed
elucidate
lethal
embryotoxicity
determine
underlying
molecular
pathways
influencing
using
a
zebrafish
model
through
multi-omics
analysis.
was
microinjected
embryos
at
1-cell
stage
with
varying
concentrations
(50
mM,
100
200
400
800
mM).
From
results,
hatching
rates
decreased
dose
dependent
manner.
Fetal
malformation
mortality
(LC50
=
339.8
mM)
increased
In
situ
hybridization
whole-embryo
assays
demonstrated
that
exerts
significant
impact
initial
stages
development,
leading
aberrant
differentiation
germ
layers,
perturbed
organogenesis,
delayed
development.
Furthermore,
transcriptomics,
metabolomics,
lipidomics
were
mechanisms
toxicity.
The
results
showed
cell
cycle,
dorsoventral
axis
formation,
collecting
duct
acid
secretion
significantly
altered
treated
embryos.
brief,
these
provide
useful
information
toxicity
mechanism
overdose
clues
for
further
studies
humans.
Language: Английский
Lactobacillus Helveticus Alleviates Cognitive Impairment Via Microbiota-Regulated Phosphatidylcholine Metabolism
Yuting Zhou,
No information about this author
Yang Jiang,
No information about this author
Aonan Xia
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et al.
Food Bioscience,
Journal Year:
2025,
Volume and Issue:
unknown, P. 106746 - 106746
Published: May 1, 2025
Language: Английский
Evaluating the link between the dietary intake of vitamin B and constipation: a population-based study
Wenyuan Yang,
No information about this author
Chenyu Jiang,
No information about this author
Yaojian Shao
No information about this author
et al.
Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: May 29, 2025
Background
Prior
research
has
established
a
correlation
between
dietary
micronutrient
intake
and
the
risk
of
developing
constipation.
However,
potential
link
vitamin
B
constipation
yet
to
be
fully
explored.
This
study
sought
assess
association
chronic
based
on
National
Health
Nutrition
Examination
Survey
(NHANES)
data.
Methods
employed
NHANES
data
collected
2005
2010,
including
total
13,885
participants
20
+
years
age.
Dietary
vitamins
B1,
B2,
niacin,
B6,
folic
acid,
choline,
B12
was
assessed
using
first
24-h
recall
interview.
Constipation
defined
Bristol
Stool
Form
Scale
(BSFS).
A
weighted
logistic
regression
model
restricted
cubic
spline
(RCS)
analysis
were
utilized
adjust
for
demographic
lifestyle-related
variables
probe
relationship
Statistical
significance
set
at
two-tailed
p
-value
<
0.05.
Confidence
intervals
(95%
CIs)
calculated
regression.
Results
The
revealed
nonlinear
inverse
all
examined
risk.
In
particular,
significant
reduction
in
odds
observed
highest
quartiles
niacin
(OR
=
0.76,
95%
CI:
0.59–0.99,
trend
0.003),
folate
0.61,
0.48–0.79,
0.001),
choline
0.77,
0.60–1.00,
0.05)
when
that
adjusted.
Subgroup
analyses
further
indicated
alcohol
consumption
significantly
modified
(p
interaction
B1
0.004),
0.04),
0.02),
Conclusion
Increased
may
contribute
reduced
constipation,
particularly
among
specific
population
subgroups.
These
results
offer
additional
support
role
modifications
promoting
gut
health.
Language: Английский