Evaluating the link between the dietary intake of vitamin B and constipation: a population-based study DOI Creative Commons

Wenyuan Yang,

Chenyu Jiang,

Yaojian Shao

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: May 29, 2025

Background Prior research has established a correlation between dietary micronutrient intake and the risk of developing constipation. However, potential link vitamin B constipation yet to be fully explored. This study sought assess association chronic based on National Health Nutrition Examination Survey (NHANES) data. Methods employed NHANES data collected 2005 2010, including total 13,885 participants 20 + years age. Dietary vitamins B1, B2, niacin, B6, folic acid, choline, B12 was assessed using first 24-h recall interview. Constipation defined Bristol Stool Form Scale (BSFS). A weighted logistic regression model restricted cubic spline (RCS) analysis were utilized adjust for demographic lifestyle-related variables probe relationship Statistical significance set at two-tailed p -value < 0.05. Confidence intervals (95% CIs) calculated regression. Results The revealed nonlinear inverse all examined risk. In particular, significant reduction in odds observed highest quartiles niacin (OR = 0.76, 95% CI: 0.59–0.99, trend 0.003), folate 0.61, 0.48–0.79, 0.001), choline 0.77, 0.60–1.00, 0.05) when that adjusted. Subgroup analyses further indicated alcohol consumption significantly modified (p interaction B1 0.004), 0.04), 0.02), Conclusion Increased may contribute reduced constipation, particularly among specific population subgroups. These results offer additional support role modifications promoting gut health.

Language: Английский

Qingre Sanjie Formula alleviates atherosclerosis by promoting LXR-α/ABCG5/G8-mediated reverse cholesterol transport and bile acid synthesis DOI
Xiao Li,

Xianglong Huang,

K.H. Song

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156691 - 156691

Published: March 1, 2025

Language: Английский

Citations

0
Lethal toxicity of metformin on zebrafish during early embryonic development by multi-omics analysis DOI Creative Commons
Ziyuan Lin, Mingfeng Liu, Feng Chen

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 2, 2025

Metformin is an antidiabetic drug used in type 2 diabetes as well indicators polycystic ovary syndrome (PCOS) and cancer. Due to their increase popularity, high amounts of metformin are being released into aquatic environments. However, the toxic effect on embryonic development organisms remains limited. Therefore, this study aimed elucidate lethal embryotoxicity determine underlying molecular pathways influencing using a zebrafish model through multi-omics analysis. was microinjected embryos at 1-cell stage with varying concentrations (50 mM, 100 200 400 800 mM). From results, hatching rates decreased dose dependent manner. Fetal malformation mortality (LC50 = 339.8 mM) increased In situ hybridization whole-embryo assays demonstrated that exerts significant impact initial stages development, leading aberrant differentiation germ layers, perturbed organogenesis, delayed development. Furthermore, transcriptomics, metabolomics, lipidomics were mechanisms toxicity. The results showed cell cycle, dorsoventral axis formation, collecting duct acid secretion significantly altered treated embryos. brief, these provide useful information toxicity mechanism overdose clues for further studies humans.

Language: Английский

Citations

0
Lactobacillus Helveticus Alleviates Cognitive Impairment Via Microbiota-Regulated Phosphatidylcholine Metabolism DOI
Yuting Zhou, Yang Jiang,

Aonan Xia

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106746 - 106746

Published: May 1, 2025

Language: Английский

Citations

0
Evaluating the link between the dietary intake of vitamin B and constipation: a population-based study DOI Creative Commons

Wenyuan Yang,

Chenyu Jiang,

Yaojian Shao

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: May 29, 2025

Background Prior research has established a correlation between dietary micronutrient intake and the risk of developing constipation. However, potential link vitamin B constipation yet to be fully explored. This study sought assess association chronic based on National Health Nutrition Examination Survey (NHANES) data. Methods employed NHANES data collected 2005 2010, including total 13,885 participants 20 + years age. Dietary vitamins B1, B2, niacin, B6, folic acid, choline, B12 was assessed using first 24-h recall interview. Constipation defined Bristol Stool Form Scale (BSFS). A weighted logistic regression model restricted cubic spline (RCS) analysis were utilized adjust for demographic lifestyle-related variables probe relationship Statistical significance set at two-tailed p -value < 0.05. Confidence intervals (95% CIs) calculated regression. Results The revealed nonlinear inverse all examined risk. In particular, significant reduction in odds observed highest quartiles niacin (OR = 0.76, 95% CI: 0.59–0.99, trend 0.003), folate 0.61, 0.48–0.79, 0.001), choline 0.77, 0.60–1.00, 0.05) when that adjusted. Subgroup analyses further indicated alcohol consumption significantly modified (p interaction B1 0.004), 0.04), 0.02), Conclusion Increased may contribute reduced constipation, particularly among specific population subgroups. These results offer additional support role modifications promoting gut health.

Language: Английский

Citations

0