Nature reviews. Cancer, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Language: Английский
Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(6), P. 537 - 551
Published: May 17, 2024
Cancer cells perturb lipid metabolic pathways for a variety of pro-tumorigenic functions, and deregulated cellular metabolism is hallmark cancer cells. Although alterations in have been appreciated over 20 years, there are no FDA-approved treatments that target lipid-related pathways. Recent advances pertaining to cell fatty acid synthesis (FAS), desaturation, uptake, microenvironmental dietary lipids, tumor-infiltrating immune illuminated promising clinical applications targeting metabolism. This review highlights emerging targets tumor may soon impact treatment.
Language: Английский
Citations
21
Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 134(2)
Published: Jan. 15, 2024
Immunometabolism is a burgeoning field of research that investigates how immune cells harness nutrients to drive their growth and functions. Myeloid play pivotal role in tumor biology, yet metabolic influence on antitumor responses remains inadequately understood. This Review explores the landscape tumor-associated macrophages, including immunoregulatory roles glucose, fatty acids, glutamine, arginine, alongside tools used perturb metabolism promote immunity. The confounding inhibitors our interpretation myeloid phenotypes will also be discussed. A binary schema currently describe macrophage immunological phenotypes, characterizing inflammatory M1 as supported by glycolysis, immunosuppressive M2 oxidative phosphorylation. However, this classification likely underestimates variety states vivo. Understanding these nuances critical when developing interventional strategies. Future should focus refining drug specificity targeted delivery methods maximize therapeutic efficacy.
Language: Английский
Citations
17
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: Nov. 21, 2024
Metabolic alterations, a hallmark of cancer, enable tumor cells to adapt their environment by modulating glucose, lipid, and amino acid metabolism, which fuels rapid growth contributes treatment resistance. In primary breast metabolic shifts such as the Warburg effect enhanced lipid synthesis are closely linked chemotherapy failure. Similarly, metastatic lesions often display distinct profiles that not only sustain but also confer resistance targeted therapies immunotherapies. The review emphasizes two major aspects: mechanisms driving in both how unique environments sites further complicate treatment. By targeting vulnerabilities at stages, new strategies could improve efficacy existing provide better outcomes for cancer patients.
Language: Английский
Citations
16
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: Feb. 20, 2025
The progression of malignant tumors leads to the development secondary in various organs, including bones, brain, liver, and lungs. This metastatic process severely impacts prognosis patients, significantly affecting their quality life survival rates. Research efforts have consistently focused on intricate mechanisms underlying this corresponding clinical management strategies. Consequently, a comprehensive understanding biological foundations tumor metastasis, identification pivotal signaling pathways, systematic evaluation existing emerging therapeutic strategies are paramount enhancing overall diagnostic treatment capabilities for tumors. However, current research is primarily metastasis within specific cancer types, leaving significant gaps our complex cascade, organ-specific tropism mechanisms, targeted treatments. In study, we examine sequential processes elucidate driving organ-tropic systematically analyze tumors, those tailored organ involvement. Subsequently, synthesize most recent advances technologies challenges opportunities encountered pertaining bone metastasis. Our objective offer insights that can inform future practice crucial field.
Language: Английский
Citations
3
Nature reviews. Cancer, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Language: Английский
Citations
2