Cited by Integrating proteomics and metabolomics to elucidate the regulatory mechanisms of pimpled egg production in chickens

The Interface of Tumour-Associated Macrophages with Dying Cancer Cells in Immuno-Oncology DOI

Isaure Vanmeerbeek, Jannes Govaerts, Raquel S. Laureano

et al.

Cells, Journal Year: 2022, Volume and Issue: 11(23), P. 3890 - 3890

Published: Dec. 2, 2022

Tumour-associated macrophages (TAMs) are essential players in the tumour microenvironment (TME) and modulate various pro-tumorigenic functions such as immunosuppression, angiogenesis, cancer cell proliferation, invasion metastasis, along with resistance to anti-cancer therapies. TAMs also mediate important anti-tumour can clear dying cells via efferocytosis. Thus, not surprisingly, exhibit heterogeneous activities functional plasticity depending on type context of death that they faced with. This ultimately governs both anti-tumorigenic activity TAMs, making interface between very for modulating growth efficacy chemo-radiotherapy or immunotherapy. In this review, we discuss from perspectives pathways, TME-driven variations, TAM heterogeneity cell-death-inducing We believe a better understanding how influence lead improved combinatorial therapies, especially combination TAM-targeting immunotherapies.

Language: Английский

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Single-cell RNA sequencing in cancer research: discovering novel biomarkers and therapeutic targets for immune checkpoint blockade DOI

Boyu Sun,

Ziyu Xun,

Nan Zhang

et al.

Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)

Published: Dec. 8, 2023

Immune checkpoint blockade (ICB) has become a promising strategy in treating advanced cancers, providing significant survival benefits for patients with various cancer types. However, among the vast population of patients, only small fraction are able to respond and derive from ICB therapy. Numerous factors contribute diminished efficacy ICB, complex tumor microenvironment (TME) playing an important role. Therefore, comprehensively understanding intricate composition TME is critical elucidating mechanisms that underlie distinct responses patients. Single-cell RNA sequencing (scRNA-seq) novel technique reveals gene expression profiles individual cells, facilitating investigation heterogeneity at high resolution identification key cell subsets participating response ICB. This review emphasizes importance scRNA-seq studying summarizes recent findings discovery biomarkers predict potential therapeutic targets immunotherapy. These suggest future directions clinical implementation immunotherapy, further advancements precision medicine.

Language: Английский

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Glucose Metabolism Reprogramming of Immune Cells in the Microenvironment of Pancreatic and Hepatobiliary Cancers DOI

Yongqing Zhao,

Weixiong Zhu,

Shi Dong

et al.

Journal of Gastroenterology and Hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Pancreatic and hepatobiliary cancers are increasing in prevalence contribute significantly to cancer-related mortality worldwide. Emerging therapeutic approaches, particularly immunotherapy, gaining attention for their potential harness the patient's immune system combat these tumors. Understanding role of cells tumor microenvironment (TME) metabolic reprogramming is key developing more effective treatment strategies. This review aims explore relationship between cell function glucose metabolism TME pancreatic cancers. synthesizes current research on adaptations cells, specifically focusing within We examine mechanisms by which influence progression through how interactions can be targeted purposes. Immune undergo significant changes, with playing a central modulating responses. These shifts not only affect but also behavior progression. The unique features provide new opportunities targeting responses malignancies effectively. complex offers promising By interventions, it may possible improve efficacy immunotherapies better aggressive

Language: Английский

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A Review on the Role of Human Solute Carriers Transporters in Cancer DOI

Md. Shafiul Hossen,

Mohammed Shafin Ul Islam,

Mohammad Yasin Mohammad

et al.

Health Science Reports, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 1, 2025

ABSTRACT Background and Aim The high rate of tumor growth results in an increased need for amino acids. As solute carriers (SLC) transporters are capable transporting different acids, cancer may develop as a result these transporters' over‐expression due to their complex formation with other biological molecules. Therefore, this review investigated the role SLC progression cancer. Methods We retrieved data from Google Scholar, Web Science, PubMed, Cochrane Library, EMBASE regarding influence human SLCs on development Articles published English before August 2024 were included study. Results overexpression is strongly related cell proliferation angiogenesis number types including thyroid, pancreatic, lung, hepatocellular, colon cancers. They crucial stimulation several signaling pathways, particularly mTOR kinase activity, which starts cascade, protein synthesis, growth, proliferation, inhibits apoptosis cancerous cells. Furthermore, they contribute activation PI3K/AKT signaling, has impact invasion, death Thus, become potential therapeutic target that plays drug resistance, microenvironment regulation, modulation immune response. Conclusion recognized progression. confirm our findings, case‐control study required investigate acid development.

Language: Английский

Citations

Integrating proteomics and metabolomics to elucidate the regulatory mechanisms of pimpled egg production in chickens DOI

Wenqiang Li, Xueying Ma, Xiaomin Li

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: 104(2), P. 104818 - 104818

Published: Jan. 15, 2025

Language: Английский

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