Molecular Interactions of Tannic Acid with Proteins Associated with SARS-CoV-2 Infectivity

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(5), P. 2643 - 2643

Published: Feb. 27, 2022

The overall impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on our society is unprecedented. identification small natural ligands that could prevent the entry and/or replication remains a pertinent approach to fight disease (COVID-19) pandemic. Previously, we showed phenolic compounds corilagin and 1,3,6-tri-O-galloyl-β-D-glucose (TGG) inhibit interaction between SARS-CoV-2 spike protein receptor binding domain (RBD) angiotensin-converting enzyme (ACE2), target cell membrane host organism. Building these promising results, now assess effects two other crucial targets involved in replication, respectively: transmembrane protease serine (TMPRSS2) 3-chymotrypsin like (3CLpro) inhibitors. Since corilagin, TGG, tannic acid (TA) share many physicochemical structural properties, investigate TA targets. In this work, combination experimental methods (biochemical inhibition assays, surface plasmon resonance, quartz crystal microbalance with dissipation monitoring) confirms potential role prevention infectivity through extracellular RBD/ACE2 interactions TMPRSS2 3CLpro activity. Moreover, molecular docking prediction followed by dynamic simulation mechanics Poisson-Boltzmann area (MMPBSA) free energy calculation also shows binds RBD, TMPRSS2, higher affinities than TGG corilagin. Overall, results suggest naturally occurring candidate SARS-CoV-2.

Language: Английский

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Antiviral Polymers: A Review

Polymers, Journal Year: 2022, Volume and Issue: 14(9), P. 1634 - 1634

Published: April 19, 2022

Polymers, due to their high molecular weight, tunable architecture, functionality, and buffering effect for endosomal escape, possess unique properties as a carrier or prophylactic agent in preventing pandemic outbreak of new viruses. Polymers are used reduce the minimum required dose, bioavailability, therapeutic effectiveness antiviral agents. also multifunctional nanomaterials to, directly indirectly, inhibit viral infections. Multifunctional polymers can interact with envelope glycoproteins on surface block fusion entry virus host cell. indirectly mobilize immune system by activating macrophages natural killer cells against invading virus. This review covers synthetic that activity, mechanism action, material like chemical composition, functional groups, charge density activity. Natural carrageenan, chitosan, fucoidan, phosphorothioate oligonucleotides, dendrimers sialylated reviewed. discusses steps replication cycle from binding cell receptors viral-cell fusion, replication, assembly, release interfere

Language: Английский

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Virucidal N95 Respirator Face Masks via Ultrathin Surface-Grafted Quaternary Ammonium Polymer Coatings

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(22), P. 25135 - 25146

Published: May 25, 2022

N95 respirator face masks serve as effective physical barriers against airborne virus transmission, especially in a hospital setting. However, conventional filtration materials, such nonwoven polypropylene fibers, have no inherent virucidal activity, and thus, the risk of surface contamination increases with wear time. The ability to protect infection can be likely improved by incorporating components that deactivate viruses on contact. We present facile method for covalently attaching antiviral quaternary ammonium polymers fiber surfaces fabrics are commonly used materials respirators via ultraviolet (UV)-initiated grafting biocidal agents. Here, C12-quaternized benzophenone is simultaneously polymerized grafted onto melt-blown or spunbond fabric using 254 nm UV light. This generated ultrathin polymer coatings which imparted permanent cationic charge without grossly changing morphology air resistance across filter. For polypropylene, comprises active layer masks, efficiency was negatively impacted from 72.5 51.3% uncoated coated single-ply samples, respectively. Similarly, directly applying full decreased 90.4 79.8%. effect due exposure organic solvents coating process. N95-level could achieved wearing over an mask fabricating exterior layer. Coated demonstrated broad-spectrum antimicrobial activity several lipid-enveloped viruses, well Staphylococcus aureus Escherichia coli bacteria. example, 4.3-log reduction infectious MHV-A59 3.3-log SuHV-1 after contact filters were observed, although level viral deactivation varied significantly depending strain protocol assaying infectivity.

Language: Английский

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Green Approaches, Potentials, and Applications of Zinc Oxide Nanoparticles in Surface Coatings and Films

Bioinorganic Chemistry and Applications, Journal Year: 2022, Volume and Issue: 2022(1)

Published: Jan. 1, 2022

Interest in the use of zinc oxide nanoparticles (ZnO NPs) surface coatings and films has increased as its incorporation can significantly improve mechanical antimicrobial properties film solutions. In an effort to produce green or eco-friendly products, potential ZnO NPs biosynthesized from natural resources replace conventional petroleum-derived polymers been investigated. This review provides insight into growing trend incorporating synthetic semi-synthetic bio-based polymeric materials via different synthesis methods well characteristics applications films. The inhibit growth various types microorganisms impart activities that prevent spread microorganisms, especially COVID-19 virus, was also discussed.

Language: Английский

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Nanoparticles in clinical trials of COVID-19: An update

International Journal of Surgery, Journal Year: 2022, Volume and Issue: 104, P. 106818 - 106818

Published: Aug. 1, 2022

Language: Английский

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