Multiphoton fluorescence microscopy for in vivo imaging

Cell, Journal Year: 2024, Volume and Issue: 187(17), P. 4458 - 4487

Published: Aug. 1, 2024

Language: Английский

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Advanced near‐infrared light approaches for neuroimaging and neuromodulation

BMEMat, Journal Year: 2023, Volume and Issue: 1(2)

Published: May 5, 2023

Abstract Almost all physiological processes of animals are controlled by the brain, including language, cognitive, memory, learning, emotion and so forth. Minor brain dysfunction usually leads to diseases disorders. Therefore, it' is greatly meaningful urgent for scientists have a better understanding structure function. Optical approaches can provide powerful tools imaging modulating brain. In particular, optical in near‐infrared (NIR) window (700–1700 nm) exhibit excellent prosperities deep tissue penetration low scattering absorption compared with those visible windows (400–700 nm), which provides promising approach develop desired methods neuroimaging neuromodulation tissues. this review, variable types NIR light neural ions, membrane potential, neurotransmitters, other critical molecules functions summarized. latest breakthrough research regulation NIR‐II (1000–1700 highlighted. Finally, we conclude challenges prospects light‐based both basic further clinical translation.

Language: Английский

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Human REM sleep recalibrates neural activity in support of memory formation

Science Advances, Journal Year: 2023, Volume and Issue: 9(34)

Published: Aug. 25, 2023

The proposed mechanisms of sleep-dependent memory consolidation involve the overnight regulation neural activity at both synaptic and whole-network levels. Now, there is a lack in vivo data humans elucidating if, how, sleep its varied stages balance activity, if such recalibration benefits memory. We combined electrophysiology with two-photon calcium imaging rodents as well intracranial scalp electroencephalography (EEG) to reveal key role for non-oscillatory brain during rapid eye movement (REM) mediate population dynamics. extent this REM predicted success consolidation, expressly modulation hippocampal-neocortical favoring remembering rather than forgetting. findings describe mechanism how human modulates enhance long-term

Language: Английский

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Network state transitions during cortical development

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(8), P. 535 - 552

Published: May 23, 2024

Language: Английский

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Deep-brain optical recording of neural dynamics during behavior

Neuron, Journal Year: 2023, Volume and Issue: 111(23), P. 3716 - 3738

Published: Oct. 6, 2023

Language: Английский

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FIOLA: an accelerated pipeline for fluorescence imaging online analysis

Nature Methods, Journal Year: 2023, Volume and Issue: 20(9), P. 1417 - 1425

Published: Sept. 1, 2023

Language: Английский

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Analysis methods for large-scale neuronal recordings

Science, Journal Year: 2024, Volume and Issue: 386(6722)

Published: Nov. 7, 2024

Simultaneous recordings from hundreds or thousands of neurons are becoming routine because innovations in instrumentation, molecular tools, and data processing software. Such can be analyzed with science methods, but it is not immediately clear what methods to use how adapt them for neuroscience applications. We review, categorize, illustrate diverse analysis neural population describe these have been used make progress on longstanding questions neuroscience. review a variety approaches, ranging the mathematically simple complex, exploratory hypothesis-driven, recently developed more established methods. also some common statistical pitfalls analyzing large-scale data.

Language: Английский

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Mapping conservative Fokker–Planck entropy in neural systems

Journal of Physics D Applied Physics, Journal Year: 2025, Volume and Issue: 58(14), P. 145401 - 145401

Published: Feb. 18, 2025

Abstract Mapping the flow of information through networks brain remains one most important challenges in computational neuroscience. In certain cases, this can be approximated by considering just two contributing factors—a predictable drift and a randomized diffusion. We show here that uncertainty associated with such drift-diffusion process calculated terms entropy Fokker–Planck equation. This entropic evolution comprises components: an irreversible spread always increases over time reversible current increase or decrease locally within system. apply dynamic decomposition to two-photon imaging data collected murine visual cortex. Our analysis reveals maps conserved emanating from lateral medial, anterolateral, rostrolateral regions toward primary cortex (V1). These results highlight role V1 as sink, facilitating redistribution throughout findings offer new insights into hierarchical organization cortical processing provide framework for exploring dynamics complex dynamical systems.

Language: Английский

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Cancer neuroscience in head and neck: interactions, modulation, and therapeutic strategies

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 31, 2025

Head and neck cancer (HNC) is an aggressive malignancy with significant effects on the innervation. Not only it at top of spectrum a dismal prognosis, but also imposes considerable stress patients society owing to frequent neurological symptoms. With progress in neuroscience, interactions between HNC nervous system, as well underlying mechanisms, have become increasingly clear. Compelling evidence suggests communication information nerve cells devastation system tumor growth. However, thorough grasp neuroscience has been severely constrained by intricacy fragmented research. This review comprehensively organizes summarizes latest research crosstalk system. It aims clarify various aspects HNC, including physiology, progression, treatment cancer. Furthermore, opportunities challenges are discussed, which offers fresh perspectives diagnosis management.

Language: Английский

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On the biological basis of beauty

Biological reviews/Biological reviews of the Cambridge Philosophical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

ABSTRACT The world around us is full of beauty. Explaining a sense the beautiful has beguiled philosophers and artists for millennia, but scientists have also pondered beauty, most notably Darwin, who used beauty to describe sexual ornaments that he argued were subject female mate choice. In doing so, ascribed ‘sense beautiful’ non‐human animals. Darwin's ideas about choice not widely accepted, however. Humans may experience assuming same other animals risks anthropomorphism: we might find tail peacock be beautiful, there no reason believe peahens do. Moreover, choice, resurrected as an object serious study in 1970s, simply requires attraction, necessarily However, recent advances psychology cognitive neuroscience are providing new, mechanistic framework Here take these findings apply them evolutionary biology. First, review progress human empirical aesthetics provide biological definition Central this discovery merely processing information can hedonic reward. As such, propose pleasure fluent processing, independent function or consummatory reward provided by stimulus . We develop context three key attributes (pleasure, interaction, disinterestedness) psychological distinction between ‘wanting’ ‘liking’. Second, show how provides proximate approach studying evolution signalling help resolve some problems, such mating biases evolve. situate within more general animal signals, suggesting only ornaments, traits diverse aposematic signals camouflage. Third, outline variety experimental approaches test whether their intended receivers, including tests fluency impact using behavioural neurological approaches.

Language: Английский

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