Plasma triacylglycerol length and saturation level mark healthy aging groups in humans DOI
Weisha Li, Bauke V. Schomakers, Michel van Weeghel

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Language: Английский

Delayed molecular aging, preservation of energy metabolism and enhanced exercise response in exercise-trained human muscle DOI Creative Commons
Georges E. Janssens,

Marit Kotte,

Lotte Grevendonk

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Abstract Exercise is fundamental to healthy aging, yet the degree which it mitigates age-related molecular changes and how varying physical fitness levels influence response exercise with age remain unclear. To address this, we performed transcriptomics, lipidomics, metabolomics on skeletal muscle of young older adults differing function, both before after an acute bout sub-maximal exercise. At baseline, exhibited reduced expression genes associated cellular respiration energy metabolism compared comparable activity levels. Remarkably, in trained adults, 50% these differences were absent, resulting transcriptomic profiles for that closely aligned those adults. Following exercise, demonstrated responses more resembled younger individuals. While all participants displayed transcriptional immune stress upon magnitude correlated positively their fitness. These findings underscore capacity sustained training transform profiles, highlight a positive link between level exercise-induced inflammation provide multi-omic atlas examining aging regulatory networks.

Language: Английский

Citations

0
Sirt2 deficiency aggravates intramuscular adipose tissue infiltration and impairs myogenesis with aging in male mice DOI
Eunjoo H. Lee, Sunyoung Park, Kyu‐Shik Jeong

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(3)

Published: April 21, 2025

Language: Английский

Citations

0
Potential implications of natural compounds on aging and metabolic regulation DOI

Zhuozhen Li,

Lili Chen,

Liangliang Qu

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102475 - 102475

Published: Aug. 31, 2024

Language: Английский

Citations

2
Lipid imaging mass spectrometry: Towards a new molecular histology DOI Creative Commons

Ibai Cavo,

Olatz Fresnedo, Lorena Mosteiro

et al.

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Journal Year: 2024, Volume and Issue: unknown, P. 159568 - 159568

Published: Oct. 1, 2024

Language: Английский

Citations

1
The aging lipidome: exercise is medicine DOI Creative Commons
Abel Plaza‐Florido, Inmaculada Pérez‐Prieto, Alejandro Lucía

et al.

Trends in Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(11), P. 1001 - 1003

Published: June 24, 2024

The molecular mechanisms behind the potential 'anti-aging' effects of exercise remain to be elucidated. Janssens et al. studied lipidome different mouse tissues and human skeletal muscle. They identified an evolutionary conserved 'lipid aging' signature, characterized by bis(monoacylglycero)phosphate accumulation, which, at muscle level, can attenuated exercise.

Language: Английский

Citations

0
Plasma triacylglycerol length and saturation level mark healthy aging groups in humans DOI Open Access
Weisha Li, Bauke V. Schomakers, Michel van Weeghel

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 26, 2024

Abstract Complex lipids, essential components in biological processes, exhibit conserved age-related changes that alter membrane properties, cellular functions, and are implicated as biomarkers contributors to longevity diseases. While physical activity alleviates comorbidities impairments, comprehensive exploration of the underlying mechanisms, particularly at level complex remains limited. However, clinical studies suggest may counteract these lipidomic changes, presenting a promising avenue for intervention. We performed profiling plasma from an extensively characterized cohort young aged individuals. Annotating 1446 unique lipid species across 24 classes we found most prominent difference older adults was accumulation triacylglycerols (TGs), with lower levels associated higher TG reduced functionality. Remarkably, class did not accumulate uniformly. Rather, our study unveiled negative correlation between TGs shorter chain length more double bonds this demographic. Overall, research highlights saturation can help mark healthy aging groups humans. These findings deepen understanding how affects influence on process.

Language: Английский

Citations

0
The translation initiation factor eIF2α regulates lipid homeostasis and metabolic aging DOI Creative Commons
Haipeng Huang, Yilie Liao, Ning Li

et al.

Aging Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Abstract Aging is usually accompanied by excessive body fat gain, leading to increased susceptibility comorbidities. This study aimed explore an unexpected function for the eukaryotic initiation factor‐2α (eIF2α) during aging. Reducing eIF2α dose led a reconfiguration of metabolic equilibrium, promoting catabolism, facilitating lipolysis, and decreasing accumulation while maintaining healthy glucose lipid metabolism Specifically, enhanced expression distinct messenger RNAs encoding mitochondrial electron transport chain proteins at translation level. The respiration in heterozygotes, even Deceleration was demonstrated as conserved mechanism longevity across various species. Our findings that restriction reducing could fend off multiple tissue damage improve homeostasis Hence, crucial target benefiting mammalian aging achieving delayed

Language: Английский

Citations

0
Semaglutide as a Possible Therapy for Healthy Aging: Targeting the Hallmarks of Aging DOI
Gabriela Ueta Ortiz, Ellen Cristini de Freitas

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 102, P. 102582 - 102582

Published: Nov. 14, 2024

Language: Английский

Citations

0
Long-Term Propolis Intake-Induced Liver Lipid Remodeling in Mice: Effects on Phospholipid-to-Glycerolipid Metabolism and Free Fatty Acid-Mediated Thermogenesis DOI
Tao Liu,

Zhuozhen Li,

Quanyuan Xie

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Research on the patterns and mechanisms of liver lipid remodeling regulated by propolis is limited. In present study, nine-month experimental duration has shed light positive influences metabolism thermogenesis capacity in livers mice. Eight major compounds were characterized using UPLC-QTOF-MS technology. Propolis significantly lowered serum triglycerides (TGs) low-density lipoprotein cholesterol (LDL-C), but it also led to increased insulin (INS) levels. Lipidomics change trend analysis 1671 components across 42 categories revealed that level glycerophospholipids (GPs) decreased while glycerolipids (GLs) fatty acids (FAs) liver. The expression levels eight key genes involved conversion GP GL pathways enhanced group. Molecular docking results elucidated high binding affinities between receptors metabolism, indicating primary possess potent capabilities for phospholipid lipolysis. These imply could facilitate browning adipose tissue, promote GPs DGs FFAs, enhance consumption FFAs through thermogenic pathways, thereby exert lipolytic hepatoprotective functions.

Language: Английский

Citations

0
Plasma triacylglycerol length and saturation level mark healthy aging groups in humans DOI
Weisha Li, Bauke V. Schomakers, Michel van Weeghel

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Language: Английский

Citations

0