Community Threat, Positive Parenting, and Accelerated Epigenetic Aging: Longitudinal Links from Childhood to Adolescence DOI Creative Commons

Georgette Metrailer,

Karina Tavares,

Mikayla Ver Pault

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Early Life Adversity (ELA) has been linked to accelerated epigenetic aging. While positive parenting is hypothesized buffer the detrimental effects of ELA on child development, its role in mitigating age acceleration remains unclear. Data from 2,039 children (49.7% female) Future Families and Child Wellbeing Study (FFCWS) were included current study (46.7% Black, 26.5% Hispanic, 19% White non-Hispanic). Home community threat observed measured ages 3 9. Salivary was at 9 15. Positive reduces pace aging low, but not high, community-threat environments. Interventions across home environments may be necessary prevent ELA's biological embedding.

Language: Английский

Gompertz law based biological age (GOLD BioAge): a simple and practical measurement of biological aging to capture morbidity and mortality risks DOI Creative Commons
Meng Hao, Hui Zhang, Jingyi Wu

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Abstract Biological age reflects actual aging and overall health, but current clocks are often complex difficult to interpret, limiting their clinical application. In this study, we introduced a Gompertz law-based biological (GOLD BioAge) model that simplified assessment. We estimated GOLD BioAge using biomarkers found significant associations of the difference from chronological (BioAgeDiff) with risks morbidity mortality in NHANES. Moreover, developed ProtAge MetAge proteomics metabolomics data, which outperformed clinical-only predicting chronic disease UK Biobank. Benchmark analysis illustrated our models exceeded common across diverse groups both NHANES The results demonstrated algorithm effectively applied omics showing excellent performance age-related outcomes. Additionally, created version called Light BioAge, used three for reliably captured validation cohorts (CHARLS, RuLAS, CLHLS). It significantly predicted onset frailty, stratified frail individuals, collectively identified individuals at high risk mortality. summary, could provide valuable framework assessment public health practice. Highlights law based was proposed construct convenient interpretable calculations, had better risks. Our approach applicable metabolomics, yielding great prospect improve accuracy prevent diseases. version, biomarkers, it independently cohorts. BioAgeDiff

Language: Английский

Citations

0
Gompertz Law-Based Biological Age (GOLD BioAge): A Simple and Practical Measurement of Biological Aging to Capture Morbidity and Mortality Risks DOI Creative Commons
Meng Hao, Xiaofeng Wang, Zixin Hu

et al.

Published: Nov. 27, 2024

Biological age reflects actual aging and overall health, but current clocks are often complex difficult to interpret, limiting their clinical application. In this study, we introduced a Gompertz law-based biological (GOLD BioAge) model that simplified assessment. We estimated GOLD BioAge using biomarkers found significant associations of the difference from chronological (BioAgeDiff) with risks morbidity mortality in NHANES. Moreover, developed ProtAge MetAge proteomics metabolomics data, which outperformed clinical-only predicting chronic disease UK Biobank. Benchmark analysis illustrated our models exceeded common across diverse groups both NHANES The results demonstrated algorithm effectively applied omics showing excellent performance age-related outcomes. Additionally, created version called Light BioAge, used three for reliably captured validation cohorts (CHARLS, RuLAS, CLHLS). It significantly predicted onset frailty, stratified frail individuals, collectively identified individuals at high risk mortality. summary, could provide valuable framework assessment public health practice.

Language: Английский

Citations

0
Gompertz Law-Based Biological Age (GOLD BioAge): A Simple and Practical Measurement of Biological Aging to Capture Morbidity and Mortality Risks DOI
Meng Hao, Hui Zhang, Jingyi Wu

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Auditory brainstem responses as a biomarker for cognition DOI Creative Commons
Yasmeen Hamza, Yang Ye,

Jennifer A. Vu

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Dec. 19, 2024

Language: Английский

Citations

0
Community Threat, Positive Parenting, and Accelerated Epigenetic Aging: Longitudinal Links from Childhood to Adolescence DOI Creative Commons

Georgette Metrailer,

Karina Tavares,

Mikayla Ver Pault

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Early Life Adversity (ELA) has been linked to accelerated epigenetic aging. While positive parenting is hypothesized buffer the detrimental effects of ELA on child development, its role in mitigating age acceleration remains unclear. Data from 2,039 children (49.7% female) Future Families and Child Wellbeing Study (FFCWS) were included current study (46.7% Black, 26.5% Hispanic, 19% White non-Hispanic). Home community threat observed measured ages 3 9. Salivary was at 9 15. Positive reduces pace aging low, but not high, community-threat environments. Interventions across home environments may be necessary prevent ELA's biological embedding.

Language: Английский

Citations

0