A nucleic acid prodrug activates mitochondrial respiration and extends lifespan DOI Open Access
Takahisa Anada,

Masakazu Kawahara,

T. Shimada

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Abstract Mitochondrial dysfunction caused by aging leads to decreased energy metabolism, resulting in functional decline and increased frailty multiple tissues. Strategies for protecting activating mitochondria under stressful conditions are required suppress age-related diseases. However, it is challenging develop drugs capable of boosting mitochondrial respiration compensating the reduced intracellular adenosine triphosphate (ATP) levels. In this study, we developed a prodrug that stimulates metabolism adenine nucleotides (AXP: monophosphate (AMP), diphosphate (ADP), ATP). It enhances AMP-activated protein kinase activity, fatty acid oxidation, oxidative stress resistance, respiration, thereby increasing ATP Furthermore, markedly extended lifespan Caenorhabditis elegans . The stimulation AXP (AXP stimulation) proposed study expected offer new strategy against pave way novel approach bioenergetic molecules drug discovery.

Language: Английский

Mitochondrial and Stress-Related Psychobiological Regulation of FGF21 in Humans DOI Creative Commons
Mangesh Kurade, Natalia Bobba-Alves, Catherine Kelly

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract FGF21 is a metabolic hormone induced by fasting, stress, and mitochondrial oxidative phosphorylation (OxPhos) defects that cause diseases (MitoD). Here we report acute psychosocial stress alone (without physical exertion) decreases serum an average of 20% ( p <0.0001) in healthy controls but increases 32% people with MitoD—pointing to functional interaction between the response OxPhos capacity regulating FGF21. We further define co-activation patterns stress-related neuroendocrine hormones novel associations factors related wellbeing, highlighting potential role for meeting energetic needs chronic stress.

Language: Английский

Citations

0
A platform to map the mind–mitochondria connection and the hallmarks of psychobiology: the MiSBIE study DOI Creative Commons
Catherine Kelly, Caroline Trumpff,

Carlos Alberto Palacio Acosta

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 35(10), P. 884 - 901

Published: Oct. 1, 2024

Language: Английский

Citations

4
Chiral Inorganic Nanomaterial‐Based Diagnosis and Treatments for Neurodegenerative Diseases DOI Open Access

Jingqi Dong,

Liguang Xu,

Aihua Qu

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Chiral nanomaterials are widely investigated over recent decades due to their biocompatibility and unique chiral effects. These key properties have significantly promoted the rapid development of in bioengineering medicine. In this review, basic principles constructing along with latest progress research comprehensively summarized. Then, application for diagnosis neurodegenerative diseases (NDDs) is systematically described. addition, significant potential broad prospects treatment NDDs highlighted from several aspects, including disaggregation neurofibrils, scavenging reactive oxygen species, regulation microbial-gut-brain axis, elimination senescent cells, promotion directed differentiation neural stem cells. Finally, a perspective challenges future provided.

Language: Английский

Citations

0
Possible Anti-Aging and Anti-Stress Effects of Long-Term Transcendental Meditation Practice: Differences in Gene Expression, EEG Correlates of Cognitive Function, and Hair Steroids DOI Creative Commons
Supaya Wenuganen, Kenneth G. Walton, Frederick Travis

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 317 - 317

Published: Feb. 20, 2025

Background: Our previous comparison of peripheral blood mononuclear cells (PBMCs) from long-term Transcendental Meditation® (TM®) practitioners and matched non-practitioner controls found 200 differentially expressed (DE) genes. Bioinformatics analyses these DE genes suggested a reduced risk diseases associated with stress aging in the TM group. Here we assessed additional signs aging. Methods: A sample 15 was studied using qPCR PBMCs 40-year (“Old TM”, n = 23) compared to “Young Control” group (n 19) an “Old 21) non-meditators. In three groups, plus 12-year practitioner 26), also EEG-based parameters cognitive function (the Brain Integration Scale (BIS), latency components event-related potential (ERP)). Finally, LC/MS/MS, persistent levels cortisol (F) its inactive congener, cortisone (E), hair. Results: analysis showed that 13 were more highly Old Controls than Young Controls. group, 7 lower Both groups had higher BIS scores their age-matched controls. The shorter N2, P3a, P3b latencies Control not longer Hair F/Hair E ratio control subgroups subgroups, F combined groups. Conclusions: These results are consistent reductions biomarkers chronic biological age meditators. They study suggesting practice lowers energy consumption or leads efficient metabolism.

Language: Английский

Citations

0
The fate of mitochondrial respiratory complexes in aging DOI Creative Commons
Hanna Salmonowicz, Karolina Szczepanowska

Trends in Cell Biology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

While mitochondrial dysfunction is one of the canonical hallmarks aging, it remains only vaguely defined. Its core feature embraces defects in energy-producing molecular machinery, respiratory complexes (MRCs). The causes and consequences these hold research attention. In this review, we assess lifecycle complexes, from biogenesis to degradation, look closely at mechanisms that could underpin their aged cells. We discuss how processes be altered by aging expand on fate MRCs age-associated pathologies. Given complexity behind MRC maintenance functionality, several traits contribute phenomenon known as dysfunction. New advances will help us better understand machinery age-related diseases.

Language: Английский

Citations

0
Age-related hearing loss: the complex interaction of carbohydrate metabolism in auditory and cognitive dysfunction during aging DOI Open Access

Shengyu Zou,

Yue Liu, Bowen Xu

et al.

Ageing and Neurodegenerative Diseases, Journal Year: 2025, Volume and Issue: 5(1)

Published: March 31, 2025

Age-related hearing loss (ARHL) is an extremely widespread form of age-related disease mainly characterized by high-frequency and subsequent cognitive dysfunction. The pathological changes associated with ARHL involve both peripheral auditory structures the central nervous system. Recent studies have focused on aging mechanisms sensors, such as cochlear hair cells, spiral ganglion stria vascularis. Additionally, role carbohydrate metabolic signaling pathways in has garnered attention, particularly regulatory effects glycolysis, glycosylation pathway, pentose phosphate pathway. dysfunction a significant clinical symptom advanced stages ARHL, growing evidence suggests that may be closely linked to Alzheimer’s disease, potentially serving risk factor for its development. In this review, we summarize specific regulators metabolism contribute ARHL. Furthermore, discuss recent research progress relationship between metabolism, loss, Finally, explore novel therapeutic targets future prospects understanding pathogenesis diagnosis related aging-associated diseases.

Language: Английский

Citations

0
A nucleic acid prodrug activates mitochondrial respiration and extends lifespan DOI Open Access
Takahisa Anada,

Masakazu Kawahara,

T. Shimada

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Abstract Mitochondrial dysfunction caused by aging leads to decreased energy metabolism, resulting in functional decline and increased frailty multiple tissues. Strategies for protecting activating mitochondria under stressful conditions are required suppress age-related diseases. However, it is challenging develop drugs capable of boosting mitochondrial respiration compensating the reduced intracellular adenosine triphosphate (ATP) levels. In this study, we developed a prodrug that stimulates metabolism adenine nucleotides (AXP: monophosphate (AMP), diphosphate (ADP), ATP). It enhances AMP-activated protein kinase activity, fatty acid oxidation, oxidative stress resistance, respiration, thereby increasing ATP Furthermore, markedly extended lifespan Caenorhabditis elegans . The stimulation AXP (AXP stimulation) proposed study expected offer new strategy against pave way novel approach bioenergetic molecules drug discovery.

Language: Английский

Citations

0