The Mechanism by Which Estrogen Level Affects Knee Osteoarthritis Pain in Perimenopause and Non-Pharmacological Measures

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2391 - 2391

Published: March 7, 2025

Perimenopausal women have fluctuating estrogen levels, which often trigger a range of symptoms perimenopausal syndromes as levels decrease. Changes in are closely related to pain knee osteoarthritis (KOA), has long been research area great interest women. In recent years, it found that an important role KOA pain, namely, can affect through the regulation inflammatory responses, inhibition cellular senescence and apoptosis, modulation neurotransmitters, may provide new ideas for treatment. This study aims describe mechanism level on perimenopause non-pharmacological measures, such physical therapy, factor traditional Chinese medicine, diet, reference treatment with KOA.

Language: Английский

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MASLD: Prevalence, Mechanisms, and Sex-Based Therapies in Postmenopausal Women

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 855 - 855

Published: April 2, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic influenced by genetic, lifestyle, and environmental factors. While MASLD more prevalent in men, women are at increased risk after menopause, highlighting critical pathogenetic role of sex hormones. The complex interplay between estrogen deficiency, visceral fat accumulation, metabolic syndrome (MetS), inflammation accelerates progression, increases cardiovascular (CV) risk, triggers a cycle worsening adiposity, dysfunction, psychological problems, including eating disorders. Weight loss postmenopausal can significantly improve both outcomes, helping to prevent related conditions. This review examines prevalence MASLD, its comorbidities (type 2 diabetes T2D, CV, mental disorders), mechanisms, pharmacological treatment with GLP-1 receptor agonists (GLP1-RAs), focus on women. Given use GLP1-RAs obesity T2D patients, increase MetS this analyzes potential stable GLP-1–estrogen conjugate as therapeutic approach subgroup. By combining synergistic effects hormones, dual agonist has been shown food intake reward suppression, resulting greater weight improved insulin sensitivity, glucose, lipid metabolism. Therefore, we hypothesize that pharmacotherapy may provide targeted benefits than either hormone alone protecting liver, β-cells, overall health. As these only supported preclinical data, highlights need for future research evaluate confirm mechanisms efficacy clinical settings, particularly

Language: Английский

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Harnessing Nature's Potential: Exploring Phytoestrogens in Cervical Cancer

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100796 - 100796

Published: April 1, 2025

Language: Английский

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Osteoporosis Is Associated with Cerebral Small Vessel Disease in Stroke-Free Individuals: A Retrospective Observational Study

Geriatrics, Journal Year: 2025, Volume and Issue: 10(3), P. 66 - 66

Published: May 9, 2025

Objectives: This study aimed to investigate the relationship between osteoporosis and cerebral small vessel disease (CSVD) burden in stroke-free individuals, as well its specific imaging markers, including lacunes, enlarged perivascular spaces (EPVSs), white matter hyperintensities (WMHs), brain atrophy (BA). Methods: A total of 684 patients who underwent both bone mineral density (BMD) assessments MRI were included. Clinical data, CSVD scores, markers CSVD, parameters collected. Logistic regression models used evaluate BMD markers. Results: Osteoporosis, hip vertebral osteoporosis, was independently associated with (OR = 2.332, 95%CI: [1.345, 4.039], p 0.003; OR 2.598, [1.540, 4.384], < 0.001; 1.515, [1.010, 2.272], 0.044). Increased spine correlated reduced 0.929, [0.887, 0.972], 0.952, [0.917, 0.989], 0.012). Hip a risk factor for lacunes 2.215, [1.197, 4.1], 0.011), multiple 2.274, [1.039, 4.980], 0.04), severe WMH 2.611, [1.171, 5.823], 0.019), EPVS ≥ 2 1.99, [1.133, 3.495], 0.017). No significant association found BA (p 0.928). In sex-stratified analyses, higher female (hip: 2.529, [1.122, 5.703], 0.025; vertebral: 3.129, [1.517, 6.455], 0.002; general osteoporosis: 1.755, [1.057, 2.912], 0.03), whereas no observed male (all > 0.05). Conclusions: Osteoporosis an increased particularly evident patients. These findings suggest that health may be important management, women.

Language: Английский

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sc-MULTI-omics approach in nano-rare diseases: understanding the pathophysiological mechanism of Mulvihill-Smith Syndrome

Functional & Integrative Genomics, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 9, 2025

Language: Английский

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Hormonal regulation of behavioral and emotional persistence: Novel insights from a systems-level approach to neuroendocrinology

Neurobiology of Learning and Memory, Journal Year: 2025, Volume and Issue: unknown, P. 108064 - 108064

Published: May 1, 2025

Language: Английский

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