Research Progress on the Interaction Between SIRT1 and Mitochondrial Biochemistry in the Aging of the Reproductive System DOI Creative Commons

Yang Li,

Kai Kang,

Huimingda Bao

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(6), P. 643 - 643

Published: June 2, 2025

The protein associated with the silencing information regulator 2-associated enzyme1 (SIRT1) is a highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase and key member of sirtuin family. SIRT1 plays an essential role in various cellular physiological processes, primarily localized nucleus but also active cytoplasm mitochondria. Recent studies have demonstrated its capacity to delay aging multiple organs tissues, although underlying mechanisms remain incompletely understood. Additionally, exerts significant influence on metabolic regulation genetic processes. As primary source energy, mitochondria are central numerous biological functions. Mitochondrial dysfunction has been implicated onset progression diseases increasingly recognized for aging-related This article investigates interaction between regulating reproductive system elucidates their potential action, providing insights clinical research into aging.

Language: Английский

Ovarian vascular aging: a hidden driver of mid-age female fertility decline DOI Creative Commons
Ge Wang,

Ruihua Yang,

Hua Zhang

et al.

npj Aging, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 30, 2025

Although ovarian reserve remains sufficient, function declines in mid-age, leading to reduced fertility around age 35, with the causes remaining unclear. Recent studies highlight vascular aging as a key factor this decline, age-related reductions remodeling disrupting oocyte development. Salidroside, natural compound that reverses and promotes angiogenesis, presents promising strategy rejuvenate health enhance fertility, offering potential for preserving reproductive aged women.

Language: Английский

Citations

0
Single-oocyte proteome-transcriptome co-profiling reveals a role of dysregulated lactate metabolism in oocyte aging DOI
Xudong Fu,

Cao Lanrui,

Yirong Jiang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Abstract The declined oocyte quality with age is a major risk factor for female infertility. Although transcriptomic changes have been examined in aged oocytes, the proteomic landscape, which reflects primary functional executors of genes, and factors shaping remains largely unexplored. This gap limits our understanding molecular features driving aging. To address this, we performed single-cell proteome/transcriptome co-profiling GV MII-aged oocytes from mice humans, revealing species- stage-specific proteomic/transcriptomic during Strikingly, observed uncoupled alterations, indicating that are not primarily driven by RNA alterations. Leveraging profiling, captured heterogeneity revealed MCT4 as conserved aging biomarker. Functional studies suggested mediated via lactate export, its inhibition improved quality. These findings indicated altered metabolism driver intervention target underscored value profiling dissecting

Language: Английский

Citations

0
Research Progress on the Interaction Between SIRT1 and Mitochondrial Biochemistry in the Aging of the Reproductive System DOI Creative Commons

Yang Li,

Kai Kang,

Huimingda Bao

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(6), P. 643 - 643

Published: June 2, 2025

The protein associated with the silencing information regulator 2-associated enzyme1 (SIRT1) is a highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase and key member of sirtuin family. SIRT1 plays an essential role in various cellular physiological processes, primarily localized nucleus but also active cytoplasm mitochondria. Recent studies have demonstrated its capacity to delay aging multiple organs tissues, although underlying mechanisms remain incompletely understood. Additionally, exerts significant influence on metabolic regulation genetic processes. As primary source energy, mitochondria are central numerous biological functions. Mitochondrial dysfunction has been implicated onset progression diseases increasingly recognized for aging-related This article investigates interaction between regulating reproductive system elucidates their potential action, providing insights clinical research into aging.

Language: Английский

Citations

0