Sleep duration and efficiency moderate the effects of prenatal and childhood ambient pollutant exposure on global white matter microstructural integrity in adolescence

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

Air pollution is a ubiquitous neurotoxicant associated with alterations in structural connectivity. Good habitual sleep may be an important protective lifestyle factor due to its involvement the brain waste clearance and bidirectional relationship immune function. Wearable multisensory devices provide more objective measures of quantity quality. We investigated whether duration efficiency moderated between prenatal childhood pollutant exposure whole-brain white matter microstructural integrity at ages 10-13 years. used multi-shell diffusion-weighted imaging data collected on 3T MRI scanners Fitbit Charge 2 from 2-year follow-up visit for 2178 subjects Adolescent Brain Cognitive Development Study®. White tracts were identified using probabilistic atlas. Restriction spectrum was performed extract restricted normalized isotropic (RNI) directional (RND) signal fraction parameters all tracts, then averaged calculate global measures. Sleep calculated by summing time spent each stage; dividing bed. Using ensemble-based modeling approach, air concentrations PM 2.5 , NO O 3 assigned child's residential addresses during period (9-month average before birthdate) as well 9- 10 Multi-pollutant linear mixed effects models assessed associations RNI RND sleep-by-pollutant interactions, adjusting appropriate covariates. interacted affect Longer higher context lower compared those similar but shorter efficiency. Low-level poses risk health youth, healthy increase resilience harmful integrity. Future studies should evaluate generalizability these results diverse cohorts utilize longitudinal understand how impact trajectories over time.

Language: Английский

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Air pollution and cortical myelin T1w/T2w ratio estimates in school-age children from the ABCD and NeuroSmog studies.

Developmental Cognitive Neuroscience, Journal Year: 2025, Volume and Issue: 73, P. 101538 - 101538

Published: Feb. 28, 2025

Air pollution affects human health and may disrupt brain maturation, including axon myelination, critical for efficient neural signaling. Here, we assess the impact of prenatal current long-term particulate matter (PM) nitrogen dioxide (NO2) exposure on cortical T1w/T2w ratios - a proxy myelin content in school-age children from Adolescent Brain Cognitive Development (ABCD) Study (United States; N = 2021) NeuroSmog study (Poland; 577), using Siemens scanners. Across both samples, found that NO2 PM were not significantly associated with except one association PM10 lower precuneus NeuroSmog. Superficially, ABCD analyses data all scanner types (Siemens, GE, Philips; 3089) revealed negative between NO₂ ratios. However, this finding could be an artifact between-site sociodemographic differences large scanner-type-related measurement differences. While significant associations air largely absent, these findings do rule out possibility during other periods/stages neurodevelopment. Future research should examine relationships across diverse populations developmental periods unified analysis methods to better understand potential neurotoxic effects pollution.

Language: Английский

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A Systematic Review of Air Pollution Exposure and Brain Structure and Function during Development

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121368 - 121368

Published: March 1, 2025

Language: Английский

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Sleep and Arousal Hubs and Ferromagnetic Ultrafine Particulate Matter and Nanoparticle Motion Under Electromagnetic Fields: Neurodegeneration, Sleep Disorders, Orexinergic Neurons, and Air Pollution in Young Urbanites

Toxics, Journal Year: 2025, Volume and Issue: 13(4), P. 284 - 284

Published: April 8, 2025

Air pollution plays a key role in sleep disorders and neurodegeneration. Alzheimer’s disease (AD), Parkinson’s (PD), and/or transactive response DNA-binding protein TDP-43 neuropathology have been documented children young adult forensic autopsies the metropolitan area of Mexico City (MMC), along with disorders, cognitive deficits, MRI brain atrophy seemingly healthy populations. Ultrafine particulate matter (UFPM) industrial nanoparticles (NPs) reach urbanites’ brains through nasal/olfactory, lung, gastrointestinal tract, placental barriers. We Fe UFPM/NPs neurovascular units, as well lateral hypothalamic nucleus orexinergic neurons, thalamus, medullary, pontine, mesencephalic reticular formation, pinealocytes. quantified ferromagnetic materials arousal hubs examined their motion behavior to low magnetic fields MMC autopsy samples from nine 25 adults AD, PD, neuropathology. Saturated isothermal remanent magnetization curves at 50–300 mT were associated UFPM/NP accumulation sleep/awake 30–50 µT (DC fields) exposure. Brain exposed anthropogenic PM found be sensitive fields, behaviors that potentially linked early development progression fatal neurodegenerative diseases disorders. Single-domain orexin system, arousal, sleep, autonomic regions, are neurodegeneration, behavioral impairment, need identify higher risk monitor environmental UFPM NP emissions exposures fields. Ubiquitous ferrimagnetic particles field threat global health.

Language: Английский

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Long-Term Exposure to Air Pollution and Road Traffic Noise in Relation to Dispensed Antidepressant Medications: A Swedish Cohort Study

Published: Jan. 1, 2025

Language: Английский

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Male-Biased Vulnerability of Mouse Brain Tryptophan/Kynurenine and Glutamate Systems to Adolescent Exposures to Concentrated Ambient Ultrafine Particle Air Pollution

NeuroToxicology, Journal Year: 2024, Volume and Issue: 104, P. 20 - 35

Published: July 11, 2024

Language: Английский

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Multivariate patterns linking brain microstructure to temperament and behavior in adolescent eating disorders

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

ABSTRACT Eating disorders (EDs) are multifaceted psychiatric characterized by varying behaviors, traits, and cognitive profiles thought to drive symptom heterogeneity severity. Non-invasive neuroimaging methods have been critical elucidate the neurobiological circuitry involved in ED-related but often focused on a limited set of regions interest and/or symptoms. The current study harnesses multivariate map microstructural morphometric patterns across entire brain multiple domains behavior symptomatology patients. Diffusion-weighted images, modeled with restriction spectrum imaging, were analyzed for 91 adolescent patients an ED 48 healthy controls. Partial least squares analysis was applied 38 behavioral measures (encompassing cognition, temperament, symptoms) restricted diffusion white matter tracts subcortical structures 65 interest. first significant latent variable explained 46.9% covariance between microstructure behavior. This retained brain-behavior correlation held-out data, where ‘undercontrolled’ profile (e.g., higher emotional dysregulation, novelty seeking; lower effortful control interoceptive awareness) linked increased tracts, particularly those joining frontal, limbic, thalamic regions. Individually-derived scores this binge-purge symptoms, compared only restrictive eating Findings demonstrate value applying modeling array relationships inherent clinical presentation EDs, their relevance providing neurobiologically-informed model future subtyping prediction efforts.

Language: Английский

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What is the relationship between exposure to environmental pollutants and severe mental disorders? A systematic review on shared biological pathways

Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 43, P. 100922 - 100922

Published: Dec. 12, 2024

Language: Английский

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