Chemistry Letters,
Journal Year:
2024,
Volume and Issue:
53(11)
Published: Oct. 30, 2024
Abstract
Camphor
and
related
monoterpenoid
natural
products
have
served
as
versatile
“chiral
pool”
materials
in
organic
chemistry
for
over
half
a
century.
Historically,
many
researchers
used
variety
of
transformations
involving
orchestrated
rearrangements
the
bornane
skeleton
to
functionalize
camphor
framework,
expanding
utility
this
chiral
building
block.
Recent
developments
C–H
functionalization
methodologies
provide
myriad
opportunities
derivatize
framework
selective
predictable
fashion.
In
review,
short
summary
methods
scaffold
using
rearrangement
is
provided
followed
by
discussion
emerging
directed
functionalizations
that
diverse
new
ways
framework.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(16), P. 10079 - 10134
Published: Aug. 1, 2023
This
review
summarizes
the
advancements
in
rhodium-catalyzed
asymmetric
C–H
functionalization
reactions
during
last
two
decades.
Parallel
to
rapidly
developed
palladium
catalysis,
rhodium
catalysis
has
attracted
extensive
attention
because
of
its
unique
reactivity
and
selectivity
reactions.
In
recent
years,
Rh-catalyzed
have
been
significantly
many
respects,
including
catalyst
design,
reaction
development,
mechanistic
investigation,
application
synthesis
complex
functional
molecules.
presents
an
explicit
outline
catalysts
ligands,
mechanism,
scope
coupling
reagents,
applications.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(13), P. 8127 - 8153
Published: June 7, 2023
The
development
of
late-stage
functionalization
(LSF)
methodologies,
particularly
C–H
functionalization,
has
revolutionized
the
field
organic
synthesis.
Over
past
decade,
medicinal
chemists
have
begun
to
implement
LSF
strategies
into
their
drug
discovery
programs,
allowing
for
process
become
more
efficient.
Most
reported
applications
drugs
and
drug-like
molecules
been
rapidly
diversify
screening
libraries
explore
structure–activity
relationships.
However,
there
a
growing
trend
toward
use
methodologies
as
an
efficient
tool
improving
molecular
properties
promising
candidates.
In
this
review,
we
comprehensively
reviewed
recent
progress
in
emerging
area.
Particular
emphasis
is
placed
on
case
studies
where
multiple
techniques
were
implemented
generate
library
novel
analogues
with
improved
properties.
We
critically
analyzed
current
scope
improve
commented
how
believe
can
transform
future.
Overall,
aim
provide
comprehensive
survey
tools
efficiently
properties,
anticipating
its
continued
uptake
programs.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(2), P. 1224 - 1243
Published: Jan. 4, 2024
Efficient
and
streamlined
synthetic
methods
that
facilitate
the
rapid
build-up
of
structurally
diverse
π-conjugated
systems
are
paramount
importance
in
quest
for
organic
optoelectronic
materials.
Among
these
methods,
transition-metal-catalyzed
oxidative
Ar–H/Ar–H
coupling
reactions
between
two
(hetero)arenes
have
emerged
as
a
concise
effective
approach
generating
wide
array
bi(hetero)aryl
fused
heteroaryl
structures.
This
innovative
bypasses
challenges
associated
with
substrate
pre-activation
processes,
thereby
allowing
creation
frameworks
were
previously
beyond
reach
using
conventional
Ar–X/Ar–M
reactions.
These
inherent
advantages
ushered
new
design
patterns
molecules
deviate
from
traditional
methods.
ground-breaking
enables
transcendence
limitations
repetitive
material
structures,
ultimately
leading
to
discovery
novel
high-performance
In
this
Perspective,
we
provide
an
overview
recent
advances
development
materials
through
utilization
We
introduce
several
notable
strategies
domain,
covering
both
directed
non-directed
strategies,
dual
chelation-assisted
strategy
ortho-C–H
arylation/cyclization
strategy.
Additionally,
shed
light
on
role
advancement
Finally,
discuss
current
existing
protocols
offer
insights
into
future
prospects
field.
Russian Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
92(12), P. RCR5104 - RCR5104
Published: Dec. 1, 2023
After
the
appearance
of
green
chemistry
concept,
which
was
introduced
in
vocabulary
early
1990s,
its
main
statements
have
been
continuously
developed
and
modified.
Currently,
there
are
10–12
cornerstones
that
should
form
basis
for
an
ideal
chemical
process.
This
review
analyzes
accumulated
experience
achievements
towards
design
products
processes
reduce
or
eliminate
use
generation
hazardous
substances.
The
presents
views
leading
Russian
scientists
specializing
various
fields
this
subject,
including
homogeneous
heterogeneous
catalysis,
fine
basic
organic
synthesis,
electrochemistry,
polymer
chemistry,
based
on
bio-renewable
feedstocks
energetic
compounds
materials.
A
new
approach
to
quantitative
evaluation
environmental
friendliness
by
authors
is
described.
<br>
bibliography
includes
1761.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Aug. 28, 2024
Considering
the
indispensable
significance
and
utilities
of
meta-substituted
pyridines
in
medicinal,
chemical
as
well
materials
science,
a
direct
meta-selective
C-H
functionalization
is
paramount
importance,
but
such
reactions
remain
limited
highly
challenging.
In
general,
established
methods
for
meta
rely
on
utilization
tailored
electrophilic
reagents
to
realize
intrinsic
polarity
match.
Herein,
we
report
complementary
electrochemical
methodology;
diverse
nucleophilic
sulfinates
allow
meta-sulfonylation
through
redox-neutral
dearomatization-rearomatization
strategy
by
tandem
dearomative
cycloaddition/hydrogen-evolution
electrooxidative
sulfonation
resulting
oxazino-pyridines/acid-promoted
rearomatization
sequence.
Besides,
several
salient
features,
including
exclusive
regiocontrol,
remarkable
substrate/functional
group
compatibility,
scale-up
potential,
facile
late-stage
modification,
have
been
demonstrated,
which
further
contributes
practicality
adaptability
this
approach.
European Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 11, 2025
Abstract
Zinc
has
been
an
overlooked
metal
in
catalysis
for
many
years.
However,
this
situation
begun
to
change
the
last
two
decades
with
a
number
of
contributions
demonstrating
that
zinc
salts
and
complexes
are
able
catalyze
transformations
typically
accomplished
catalysts
based
on
precious
transition
metals.
The
development
such
zinc‐catalyzed
methodologies
is
highly
appealing
because,
general,
easily
available,
inexpensive
less
toxic.
This
review
aims
present
most
recent
relevant
examples
use
formation
carbon‐heteroatom
bonds,
which
very
important
process
synthetic
organic
chemistry.
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(36), P. 7267 - 7289
Published: Jan. 1, 2023
Herein
we
disclose
the
synthesis
and
an
overview
of
all
functionalization
reactions
at
each
carbon
atom,
viz
,
C2,
C3,
C5,
C6,
C7
C8
imidazo[1,2-
a
]pyridine.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(18), P. 3685 - 3690
Published: Jan. 29, 2024
An
efficient
palladium-catalyzed
region-selective
C7-trifluoromethylation
of
indolines
using
commercially
available
Umemoto's
reagent
was
reported.
The
reaction
utilizing
as
CF
