Dynamic Peptide Nanoframework-Guided Protein Coassembly: Advancing Adhesion Performance with Hierarchical Structures

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Hierarchical structures are essential in natural adhesion systems. Replicating these synthetic adhesives is challenging due to intricate molecular mechanisms and multiscale processes. Here, we report three phosphorylated peptides featuring a hydrophobic self-assembly motif linked hydrophilic sequence (pSGSS), forming peptide fibril nanoframeworks. These nanoframeworks effectively coassemble with elastin-derived positively charged proteins (PCP), resulting complex coacervate-based hierarchical structures. Our method enables the controlled regulation of both cohesion properties adhesives. Notably, formed by dityrosine-containing PCP demonstrate an exceptional interfacial strength up 30 MPa, outperforming most known supramolecular rivaling cross-linked chemical Additionally, show promising biocompatibility bioactivity, making them suitable for applications such as visceral hemostasis tissue repair. findings highlight utility bioinspired assembly combined bioengineering techniques advancing biomedical

Language: Английский

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Synthesis of d-glucono-1,4-lactones modified with linear saturated fatty acids as novel low molecular-weight organogelators and evaluation of their physical properties

Soft Matter, Journal Year: 2025, Volume and Issue: 21(10), P. 1970 - 1983

Published: Jan. 1, 2025

To develop a novel low molecular-weight organogelator, D-glucono-1,4-lactones were synthesized with all hydroxy groups esterified linear saturated fatty acids, and their gelation ability was evaluated. When acid introduced, the six-membered ring D-glucono-1,5-lactone transformed into five-membered D-glucono-1,4-lactone, regardless of length acid. However, depended on acid, compounds palmitic (16 carbons) stearic (18 showed better ability. Electron microscopy that structure xerogels varied acids. Some formed fibrous structures others plate-like crystals, building up to porous structure. In addition physical properties as an emulsification crystal polymorphism confirmed, detailed polymorphic analysis through FT-IR performed estimate intermolecular packing at molecular level.

Language: Английский

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External forces align supramolecular materials

Nature Synthesis, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

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