Chinese Journal of Structural Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 100447 - 100447
Published: Oct. 1, 2024
Language: Английский
Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 115781 - 115781
Published: Feb. 1, 2025
Language: Английский
Citations
0
ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: 8(4), P. 1028 - 1049
Published: March 12, 2025
The development of precise and efficient delivery systems is pivotal for advancing CRISPR/Cas9 gene-editing technologies, particularly therapeutic applications. Engineered metal-organic frameworks (MOFs) have emerged as a promising class inorganic nonviral vectors, offering unique advantages such tunable porosity, high cargo-loading capacity, biocompatibility. This review explores the design application MOF-based nanoplatforms tailored targeted components, aiming to enhance precision efficiency. By incorporating stimuli-responsive linkers bioactive ligands, these MOFs enable controlled release payloads at target site. Comparative discussions demonstrate superior performance over conventional in terms stability, transfection efficiency, reduced off-target effects. Additionally, intracellular trafficking mechanisms potential platforms preclinical models are discussed. These findings highlight transformative overcoming challenges associated with immunogenicity cytotoxicity, paving way their medicine. provides blueprint integration nanotechnology genome editing, frontier systems.
Language: Английский
Citations
0
Nano Materials Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Accounts of Chemical Research, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 13, 2024
ConspectusThe past decades have witnessed the proliferation of porous materials offering high surface areas and revolution in gas storage separation, where metal–organic frameworks (MOFs) stand out as an important family. Alongside pursuit higher area, increase size guests, such nanoparticles biomolecules, has also led to demand for larger space defined by pores cages within MOF structure, from conventional micropore regime (<2 nm) toward mesopore (2–50 nm). Among essential elements design MOFs, molecular building blocks, their coordination spatial arrangement, chemistry design, bonds become relatively mature, precise control shape environment molecularly 3D cages; however, correlation between geometrical parameters polyhedrons describing cages, concerning arrangement is much less explored.In this Account, we made efforts associate actual cage with critical components, vertices, edges, connectivity, rings, underlying polyhedrons, well combination components various types MOFs. Several trends were found, influence connectivity expansion efficiency, insights into construction This enables creation extremely large mesoporous MOFs internal diameter up 11.4 nm small blocks. Furthermore, discuss a strategy partial removal or replacement organic linkers construct readily known topologies.All above urged us ask following questions: Is there any limit sculpting molecules? How area can one chemical bond support? The answer these questions will deepen knowledge efficient utilization spaces guide mesopores. general principals emerged: (1) Expansion efficiency radius are positively correlated number vertices. (2) Increase vertices decrease favor cages. (3) boundary constructed related polyhedron type determined energy involved crystallinity. Such likely be applicable isolated supramolecular chemistry. In addition structural synthesis, applications summarized.
Language: Английский
Citations
2
Chinese Journal of Structural Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 100447 - 100447
Published: Oct. 1, 2024
Language: Английский
Citations
0