Structure-Dependent, Switchable Alder-Ene/[2π + 2σ] Cycloadditions of Vinyl Bicyclo[1.1.0]butanes with α-Ketoesters Enabled by Palladium Catalysis

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

A structure-dependent, palladium-catalyzed switchable alder-ene/[2π + 2σ] cycloaddition of VBCBs with α-ketoesters has been reported. variety cyclobutenes and 2-oxabicyclo[2.1.1]hexanes have efficiently achieved in good to excellent yields through strain-release-driven alder-ene reactions [2π cycloadditions, respectively. The potential this method is illustrated by the scale-up reaction diverse postsynthetic transformations obtained cyclic scaffolds. Additionally, mechanism origins chemoselectivity probed computational studies.

Language: Английский

A new route to 3D bioisosteres of arenes

Trends in Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский