The impact of mild episodic ketosis on microglia and hippocampal long‐term depression in 5xFAD mice DOI Creative Commons
Jacopo Di Lucente, Jon J. Ramsey, Lee‐Way Jin

et al.

FASEB BioAdvances, Journal Year: 2024, Volume and Issue: 6(12), P. 581 - 596

Published: Oct. 23, 2024

Abstract Ketotherapeutics is a potential metabolic intervention for mitigating dementias; however, its mechanisms and optimal methods of application are not well understood. Our previous in vitro study showed that β‐hydroxybutyrate (BHB), major ketone body, reverses pathological features amyloid‐β oligomer (AβO)‐activated microglia. Here we tested the vivo effects BHB on microglia synaptic plasticity 5xFAD Alzheimer's disease (AD) mouse model. A short 1‐week regimen daily intraperitoneal injection (250 mg/kg), which induced brief mild episodic ketosis, was sufficient to mitigate pro‐inflammatory activation reduce brain deposition by enhancing phagocytosis. Remarkably, it mitigated deficits hippocampal long‐term depression but potentiation, this effect linked suppression NLRP3 inflammasome‐generated IL‐1β. As ketogenic diets known poor compliance, our opens possibility alternative approaches such as short‐term injections or dietary esters less restrictive, potentially safer, easier compliance.

Language: Английский

Estrogen signalling and Alzheimer's disease: Decoding molecular mechanisms for therapeutic breakthrough DOI

Rishabh,

Manni Rohilla, Seema Bansal

et al.

European Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 60(1), P. 3466 - 3490

Published: May 10, 2024

Abstract In females, Alzheimer's disease (AD) incidences increases as compared to males due estrogen deficiency after menopause. Estrogen therapy is the mainstay for menopause and associated complications. Estrogen, a hormone with multifaceted physiological functions, has been implicated in AD pathophysiology. plays crucial role amyloid precursor protein (APP) processing overall neuronal health by regulating various factors such brain‐derived neurotrophic factor (BDNF), intracellular calcium signalling, death domain‐associated (Daxx) translocation, glutamatergic excitotoxicity, Voltage‐Dependent Anion Channel, Insulin‐Like Growth Factor 1 Receptor, estrogen‐metabolising enzymes apolipoprotein E (ApoE) polymorphisms. All these impact physiology of postmenopausal women. replacement therapies play an important treatment strategy prevent However, use may lead increased risks breast cancer, venous thromboembolism cardiovascular disease. Various therapeutic approaches have used mitigate effects on AD. These include therapy, Selective Receptor Modulators (SERMs), Beta (ERβ)‐Selective Agonists, Transdermal Delivery, Localised Combination Therapies, Metabolism Modulation Alternative Estrogenic Compounds like genistein from soy, notable phytoestrogen plant sources. mechanism via which modulate women not explained earlier thoroughly. Present review will enlighten all molecular mechanisms Along‐with this, association between estrogen, ApoE polymorphisms also be discussed

Language: Английский

Citations

6
Executive Control from Healthy Ageing to Cognitive Impairment: A Systematic Review of Stroop and Simon effects using Psychophysiological and Imaging Techniques DOI Creative Commons
Giuseppina Elena Cipriani,

Sara Molfese,

Fabio Giovannelli

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106121 - 106121

Published: March 1, 2025

The prevalence of cognitive impairment and dementia in the ageing population emphasises need for strategies to mitigate decline. While research on Alzheimer's Disease (AD) has focused early risk factors, less attention been paid protective factors such as reserve (CR) control (CC). This review examines age-related changes prefrontal cortex (PFC) healthy impairment. We analysed studies using Stroop Simon tasks conjunction with EEG, EEG/ERP, fNIRS fMRI. Of 1411 articles reviewed, 49 met our criteria. results suggest that effects are essential distinguishing between Increased activity PFC supports task performance, especially ageing. However, when compensatory mechanisms fail, deficits may indicate reduced activation PFC. critical role CR attenuating decline highlights importance maintaining CC.

Language: Английский

Citations

0
Cognitive Aging and Neurodegenerative Disorders DOI Creative Commons
Maria Loizos, Sam Gandy, Mary Sano

et al.

Lifestyle Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 507 - 520

Published: Jan. 1, 2025

Citations

0
Anti-Alzheimer effects of an HDAC6 inhibitor, WY118, alone and in combination of lithium chloride: Synergistic suppression of ferroptosis via the modulation of tau phosphorylation and MAPK signaling DOI

Zhonghui Lu,

Zixing Jiang,

Xiaoling Huang

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177605 - 177605

Published: April 1, 2025

Language: Английский

Citations

0
Introduction to Alzheimer's Disease, Biomarkers, and the AI Revolution DOI
Bancha Yingngam

Advances in medical technologies and clinical practice book series, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: June 28, 2024

Alzheimer's disease (AD) is a progressive neurodegenerative that results in steady decline cognitive ability and memory function. As society ages, the need for an optimum AD management strategy becomes more important. This chapter analyzes stage-construction etiology escalating symptoms of discovered throughout this review, as well identification barrier to precise diagnosis. The artificial intelligence achieve quicker detection through machine learning, data analytics, predictive modeling also being considered. Therefore, employing AI AD-related studies novel approach enhancing patient outcomes. Proper diagnosis parallel increased probability many parameters one most difficult moments identify. However, use evaluation sensor network technologies big analysis has advanced, preventive instruments can be used. Thus, technology gives humanity hope stop or, at very least, slow down tragedy.

Language: Английский

Citations

1
Pathophysiology of Alzheimer’s disease: an insight into the genetic factors, hypotheses, redox imbalance, and antioxidant intervention DOI
Teslim Simisola Abdulkadir, Joseph Olusegun Ayo

Comparative Clinical Pathology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Language: Английский

Citations

1
The impact of mild episodic ketosis on microglia and hippocampal long‐term depression in 5xFAD mice DOI Creative Commons
Jacopo Di Lucente, Jon J. Ramsey, Lee‐Way Jin

et al.

FASEB BioAdvances, Journal Year: 2024, Volume and Issue: 6(12), P. 581 - 596

Published: Oct. 23, 2024

Abstract Ketotherapeutics is a potential metabolic intervention for mitigating dementias; however, its mechanisms and optimal methods of application are not well understood. Our previous in vitro study showed that β‐hydroxybutyrate (BHB), major ketone body, reverses pathological features amyloid‐β oligomer (AβO)‐activated microglia. Here we tested the vivo effects BHB on microglia synaptic plasticity 5xFAD Alzheimer's disease (AD) mouse model. A short 1‐week regimen daily intraperitoneal injection (250 mg/kg), which induced brief mild episodic ketosis, was sufficient to mitigate pro‐inflammatory activation reduce brain deposition by enhancing phagocytosis. Remarkably, it mitigated deficits hippocampal long‐term depression but potentiation, this effect linked suppression NLRP3 inflammasome‐generated IL‐1β. As ketogenic diets known poor compliance, our opens possibility alternative approaches such as short‐term injections or dietary esters less restrictive, potentially safer, easier compliance.

Language: Английский

Citations

0