Growing
wildfire
smoke
represents
a
substantial
threat
to
air
quality
and
human
health.
However,
the
impact
of
on
health
remains
imprecisely
understood
due
uncertainties
in
both
measurement
exposure
population
dose-response
functions
linking
Here,
we
compare
daily
smoke-related
surface
fine
particulate
matter
(PM
International Journal of Environmental Research and Public Health,
Journal Year:
2025,
Volume and Issue:
22(2), P. 277 - 277
Published: Feb. 14, 2025
Exposure
to
wildfire
smoke
(WFS)
is
associated
with
detrimental
physical
and
mental
health.
Periods
of
sustained
WFS
are
predicted
increase
climate
change,
affecting
populations
globally.
Using
a
retrospective
cross-sectional
study,
we
assessed
perceptions
responses
in
cohort
New
York
State
(NYS)
residents
Summer
2023.
Data
were
collected
using
an
online
survey
from
October
November
Descriptive
statistics
summarized
respondent
experiences,
while
exploratory
analyses
identified
high-risk
chi-square
t-tests.
Our
sample
consisted
609
primarily
healthy,
white,
well-educated
individuals
who
spent
most
their
time
NYS
during
Of
the
99%
that
reported
experiencing
WFS,
92%
received
91%
sought
out
WFS-related
air
quality
information.
While
only
25%
illness,
87%
experienced
at
least
one
symptom
frequently
citing
watery
eyes
(63%),
irritated
throat
(50%),
headaches
(49%),
women
reporting
symptoms
more
than
men
(89.1%
vs.
81.6%;
p
=
0.034).
A
majority
(93%)
taking
mitigation
actions,
including
avoiding
outdoor
activities
(75%)
wearing
masks
(54%).
results
highlight
widespread
impacts
wildfires
2023,
nearly
all
respondents
periods
WFS.
Most
adverse
health
despite
preventative
measures,
indicating
current
protective
strategies
may
be
insufficient
effective
interventions
needed.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 15, 2025
Abstract
January
2025
brought
devastating
wildfires
to
Los
Angeles
(LA)
County,
California,
causing
poor
air
quality,
destroying
homes
and
businesses,
displacing
thousands
of
people.
We
used
electronic
health
record
data
from
3.7
million
Kaiser
Permanente
Southern
California
members
promptly
determine
if
the
LA
Fires
increased
outpatient
acute
healthcare
utilization.
created
exposure
categories
using
maximum
wildfire
burn
zone
reached
by
an
or
Ventura
County
as
16,
2025.
Highly-exposed
resided
in
census
tracts
located
<20km
zones
moderately-exposed
lived
≥20km
but
within
County.
identified
daily
virtual
care
visits
five
categories:
all-cause,
cardiovascular,
injury,
neuropsychiatric,
respiratory.
conducted
2-stage
interrupted
time-series
analyses
machine-learning
algorithms
how
much
Across
week
following
7
ignitions,
respiratory
were
41%
(95%
empirical
confidence
interval
[eCI]:
26%,
56%)
higher
34%
eCI:
17%,
52%)
than
expected
highly-
groups,
respectively,
totaling
3,221
excess
visits.
Similarly,
both
groups
had
approximately
35%
more
cardiovascular
over
same
period.
Among
highly-exposed
members,
injury
neuropsychiatric
≥18%
on
7.
Substantial
increases
utilization
driven
primarily
care-seeking
observed
Fires.
As
disruptive
climate
events
increase,
such
are
essential
inform
preparedness
response.
Significance
statement
Climate
hazards
like
will
increasingly
impact
US
cities.
use
for
conditions
post-LA
ignitions
living
<20
km
a
anywhere
This
included
2,424
(+35%)
By
applying
our
estimates
all
residents,
we
estimated
16,171
21,541
occurred
during
ignition.
visits,
care-seeking,
suggesting
this
service
should
be
expanded
events.
JAMA Network Open,
Journal Year:
2025,
Volume and Issue:
8(4), P. e253326 - e253326
Published: April 4, 2025
Importance
A
growing
body
of
research
suggests
that
exposure
to
fine
particulate
matter
(PM
2.5
;
particle
size
microns
or
smaller)
may
be
associated
with
mental
health
outcomes.
However,
the
potential
impact
wildfire-specific
PM
on
remains
underexplored.
Objective
To
investigate
whether
emergency
department
(ED)
visits
for
conditions,
including
all-cause
and
psychoactive
substance
use,
nonmood
psychotic
disorders,
anxiety,
depression,
other
mood-affective
disorders
during
extensive
2020
California
wildfire
season.
Design,
Setting,
Participants
This
cross-sectional
study
used
data
ED
from
July
December
obtained
Department
Health
Care
Access
Information
(HCAI).
Eligible
participants
were
residents
who
presented
an
in
conditions
without
COVID-19.
The
analyzed
between
2020.
Exposure
Wildfire-specific
(with
up
7-day
lags)
based
participants’
residential
zip
codes.
Main
Outcomes
Measures
Daily
visit
counts
disease-specific
(F00-F99)
identified
using
International
Statistical
Classification
Diseases
Related
Problems,
Tenth
Revision
(ICD-10)
codes
at
code
tabulation
areas.
Results
Between
2020,
there
86
609
(median
[IQR]
patient
age,
38
[27-54]
years;
40
272
female
[46.5%];
10
657
Black
[12.3%],
30
044
Hispanic
[34.7%],
35
145
White
[40.6%]).
Visits
included
use
(23
966
[27.6%]),
(16
714
[19.3%]),
anxiety
(26
711
[30.8%]),
depression
(10
422
[12.0%]),
(5338
[6.2%]).
During
peak
months,
median
(IQR)
daily
concentration
increased
11.9
(3.9-32.5)
μg/m
3
.
10-μg/m
increase
was
higher
(cumulative
relative
risk
[cRR]
over
lag
0-7
days,
1.08;
95%
CI,
1.03-1.12),
(cRR
1.15;
1.02-1.30),
1.29;
1.09-1.54),
0-4
1.06;
1.00-1.12).
Subgroup
analyses
suggested
smoke
disproportionately
among
individuals
(eg,
depression:
cRR
1.17;
1.03-1.32)
young
people
(other
disorders:
1.46;
1.08-1.98).
Effect
modification
by
race
found,
non-Hispanic
having
0-5
2.35;
1.56-3.53)
1.30;
1.06-1.59).
Conclusions
Relevance
Wildfire
significantly
odds
subsequent
this
study,
varying
times
different
subconditions
demographic
groups.
Neuropsychopharmacology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 19, 2025
Abstract
Subanesthetic
ketamine
is
currently
used
as
a
rapid-acting
treatment
for
varied
neuropsychiatric
disorders.
However,
the
mechanistic
underpinnings
of
its
therapeutic
action
remain
unclear,
and
emerging
clinical
preclinical
evidence
highlights
potential
involvement
opioid
system.
We
pharmacological
functional
ultrasound
imaging
data
acquired
during
after
administration
in
male
female
rats
pretreated
with
naltrexone,
an
receptor
antagonist,
or
vehicle.
found
that
ketamine-induced
connectivity
changes
are
modulated
by
blockade,
these
responses
dependent
on
biological
sex.
Specifically,
naltrexone
sex-dependently
altered
patterns
within
medial
prefrontal
cortex
(mPFC),
key
node
brain’s
default-mode
network,
between
mPFC
other
nodes.
Furthermore,
produced
opioid-dependent
shift
toward
states
increased
dysconnectivity
brain
entropy
only.
Our
findings
warrant
further
investigation
into
neurophysiological
sex-specific
interactions
receptors.
EarthArXiv (California Digital Library),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 13, 2024
Growing
wildfire
smoke
represents
a
substantial
threat
to
air
quality
and
human
health
in
the
US
across
much
of
globe.
However,
impact
on
remains
imprecisely
understood,
due
uncertainties
both
measurement
population
exposure
dose-response
functions
linking
health.
Here,
we
compare
daily
smoke-related
surface
fine
particulate
matter
(PM2.5)
concentrations
estimated
using
three
approaches,
including
two
chemical
transport
models
(CTMs):
GEOS-Chem
Community
Multiscale
Air
Quality
(CMAQ),
one
machine
learning
(ML)
model
over
contiguous
2020,
historically
active
fire
year.
We
study
consequences
these
different
approaches
for
estimating
PM2.5
effects
mortality.
In
western
US,
compared
against
measurements
from
Environmental
Protection
Agency
(EPA)
PurpleAir
sensors,
find
that
CTMs
overestimate
during
extreme
episodes
by
up
3-5
fold,
while
ML
estimates
are
largely
consistent
with
measurements.
eastern
where
levels
were
lower
show
modestly
better
agreement
develop
calibration
framework
integrates
CTM-
ML-based
yields
outperform
each
individual
approach.
When
combining
county-level
mortality
rates,
low-level
but
large
discrepancies
high-level
methods.
Our
research
highlights
benefits
costs
estimation
methods
understanding
impacts
smoke,
demonstrates
importance
bench-marking
available
Journal of Epidemiology & Community Health,
Journal Year:
2024,
Volume and Issue:
unknown, P. jech - 222716
Published: Dec. 18, 2024
Climate
change
is
a
major
threat
to
global
health.
Its
effects
on
physical
health
are
increasingly
recognised,
but
mental
impacts
have
received
less
attention.
The
of
climate
can
be
direct
(resulting
from
personal
exposure
acute
and
chronic
climatic
changes),
indirect
(via
the
impact
various
socioeconomic,
political
environmental
determinants
health)
overarching
knowledge,
education
awareness
change).
These
unequally
distributed
according
long-standing
structural
inequities
which
exacerbated
by
change.
We
outline
key
concepts
pathways
through
may
affect
explore
responses
at
different
levels,
emotions
politics,
highlight
need
for
multilevel
action.
provide
broad
reference
help
guide
researchers,
practitioners
policy-makers
in
use
understanding
terms
this
rapidly
growing
interdisciplinary
field.
Climate
change
is
a
major
threat
to
global
health.
Its
effects
on
physical
health
are
increasingly
recognised,
but
mental
impacts
have
received
less
attention.
The
of
climate
can
be
through
direct
(resulting
from
personal
exposure
acute
and
chronic
climatic
changes),
indirect
(via
the
impact
various
socioeconomic,
political,
environmental
determinants
health)
overarching
knowledge,
education
awareness
change).
These
unequally
distributed
according
long-standing
structural
inequities
which
exacerbated
by
change.
We
outline
key
concepts
pathways
may
affect
explore
responses
at
different
levels,
emotions
politics,
highlight
need
for
multilevel
action.
provide
broad
reference
help
guide
researchers,
practitioners
policymakers
in
use
understanding
terms
this
rapidly
growing
interdisciplinary
field.