Neural Correlates of Resilience to Trauma During Adolescence: A Multi-Modal Study DOI
Lu Zhang, Vanessa Cropley, Divyangana Rakesh

et al.

Published: July 6, 2024

Background: Understanding resilience mechanisms is important for advancing early intervention strategies, yet research on the neurobiology of in adolescents limited. The present study examined brain structural and resting-state functional connectivity (rsFC) correlates to internalizing externalizing symptoms a large sample adolescents. Methods: We analyzed longitudinal data from 8,499 (baseline mean age 9.92 0.62 years) Adolescent Brain Cognitive Development Study. Participants were categorized as resilient, maladaptive, healthy, or vulnerable based reports traumatic events internalizing/externalizing three years later. used multinomial logistic regressions examine associations structure rsFC with resilience. Sex differences also investigated. Results: Increased odds being resilient (relative healthy) both associated between dorsal ventral attention networks hippocampus. Resilience was cingulo-opercular network found association fusiform cortical area, hippocampus, group membership maladaptive) be opposite directions males females. Conclusions: may involved salience detection encoding, some However, it unclear if our findings reflect specifically, could better interpreted reflecting trauma exposure psychopathology. This underscores need further into neurobiological basis during adolescence.

Language: Английский

Brain dynamics reflecting an intra-network brain state are associated with increased post-traumatic stress symptoms in the early aftermath of trauma DOI
Mohammad S.E. Sendi, Zening Fu, Nathaniel G. Harnett

et al.

Nature Mental Health, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

Citations

1
Sex Differences in Response Inhibition–Related Neural Predictors of Posttraumatic Stress Disorder in Civilians With Recent Trauma DOI

Bibian Borst,

Tanja Jovanović, Stacey L. House

et al.

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2024, Volume and Issue: 9(7), P. 668 - 680

Published: March 23, 2024

Language: Английский

Citations

5
Plasticity of human resilience mechanisms DOI Creative Commons
Giovanni Leone,

Hannah Casanave,

Charlotte Postel

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(2)

Published: Jan. 8, 2025

The hippocampus’s vulnerability to trauma-induced stress can lead pathophysiological disturbances that precipitate the development of posttraumatic disorder (PTSD). mechanisms resilience foster remission and mitigate adverse effects remain unknown. We analyzed evolution hippocampal morphology between 2016/2017 2018/2019, as well memory control crucial for trauma resilience. Participants were individuals exposed 2015 Paris terrorist attacks ( N = 100), including chronic 34) remitted 19) PTSD, nonexposed 72). found normalization inhibitory processes, which regulate resurgence intrusive memories in hippocampus, not only predicted PTSD but also preceded a reduction traumatic memories. Improvement was associated with interruption stress-induced atrophy region includes dentate gyrus. Human is characterized by plasticity circuits, interacts neuroplasticity.

Language: Английский

Citations

0
Investigating the Neuropsychiatric Sequelae of Traumatic Brain Injury with Hierarchical Taxonomy of Psychopathology DOI
Lucia M. Li, David L. Brody

Journal of Neurotrauma, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Language: Английский

Citations

0
Person-centered analyses reveal that developmental adversity at moderate levels and neural threat/safety discrimination are associated with lower anxiety in early adulthood DOI Creative Commons
Lucinda M. Sisk, Taylor J. Keding, Sonia Ruiz

et al.

Communications Psychology, Journal Year: 2025, Volume and Issue: 3(1)

Published: March 5, 2025

Parsing heterogeneity in the nature of adversity exposure and neurobiological functioning may facilitate better understanding how shapes individual variation risk for resilience against anxiety. One putative mechanism linking with anxiety is disrupted threat safety learning. Here, we applied a person-centered approach (latent profile analysis) to characterize patterns at specific developmental stages threat/safety discrimination corticolimbic circuitry 120 young adults. We then compared resultant profiles differed symptoms. Three latent emerged: (1) group lower lifetime adversity, higher neural activation threat, safety; (2) moderate during middle childhood adolescence, (3) minimal both safety. Individuals second had than other profiles. These findings demonstrate variability within-person combinations can differentially relate anxiety, suggest that some individuals, adolescence could be associated processes foster future

Language: Английский

Citations

0
Neural Correlates of Resilience to Trauma During Adolescence: A Multi-Modal Study DOI
Lu Zhang, Vanessa Cropley, Divyangana Rakesh

et al.

Published: July 6, 2024

Background: Understanding resilience mechanisms is important for advancing early intervention strategies, yet research on the neurobiology of in adolescents limited. The present study examined brain structural and resting-state functional connectivity (rsFC) correlates to internalizing externalizing symptoms a large sample adolescents. Methods: We analyzed longitudinal data from 8,499 (baseline mean age 9.92 0.62 years) Adolescent Brain Cognitive Development Study. Participants were categorized as resilient, maladaptive, healthy, or vulnerable based reports traumatic events internalizing/externalizing three years later. used multinomial logistic regressions examine associations structure rsFC with resilience. Sex differences also investigated. Results: Increased odds being resilient (relative healthy) both associated between dorsal ventral attention networks hippocampus. Resilience was cingulo-opercular network found association fusiform cortical area, hippocampus, group membership maladaptive) be opposite directions males females. Conclusions: may involved salience detection encoding, some However, it unclear if our findings reflect specifically, could better interpreted reflecting trauma exposure psychopathology. This underscores need further into neurobiological basis during adolescence.

Language: Английский

Citations

0