Cell membrane-camouflaged nanoparticles activate fibroblast-myofibroblast transition to promote skin wound healing DOI
Qi Jia,

Yijuan Ding,

Ziwen Su

et al.

Biofabrication, Journal Year: 2024, Volume and Issue: 17(1), P. 015036 - 015036

Published: Dec. 10, 2024

Abstract The fibroblast-myofibroblast transition marked by extracellular matrix (ECM) secretion and contraction of actomyosin-based stress fibers, plays central roles in the wound healing process. This work aims to utilize cell membrane-based nanoplatform improve outcomes dysregulated healing. membranes myofibroblasts isolated from mouse skin are used as camouflage for gold nanoparticles loaded with IL-4 cytokine. membrane-modified show effective situ clearance bacterial infection, act activator IL-4Rα signaling pathway induce pro-inflammatory M1 macrophages into anti-inflammatory M2 phenotype. Thus, poor bacteria-clearance non-stop inflammation refractory wounds improved accelerated. Furthermore, releases myofibroblast propel primitive fibroblasts toward an epigenetic manner. Matrix-production, vascularization, epithelial regeneration then initiated, leading satisfactory closure. Our study devises a new strategy activating under prolonged continuous exposure fibrotic environment, develops promising biomimetic treatment chronic

Language: Английский

From Data to Decisions: Leveraging Artificial Intelligence and Machine Learning in Combating Antimicrobial Resistance – a Comprehensive Review DOI Creative Commons
José Manuel Pérez de la Lastra, Samuel J. T. Wardell, Tarun Pal

et al.

Journal of Medical Systems, Journal Year: 2024, Volume and Issue: 48(1)

Published: Aug. 1, 2024

Abstract The emergence of drug-resistant bacteria poses a significant challenge to modern medicine. In response, Artificial Intelligence (AI) and Machine Learning (ML) algorithms have emerged as powerful tools for combating antimicrobial resistance (AMR). This review aims explore the role AI/ML in AMR management, with focus on identifying pathogens, understanding patterns, predicting treatment outcomes, discovering new antibiotic agents. Recent advancements enabled efficient analysis large datasets, facilitating reliable prediction trends responses minimal human intervention. ML can analyze genomic data identify genetic markers associated resistance, enabling development targeted strategies. Additionally, techniques show promise optimizing drug administration developing alternatives traditional antibiotics. By analyzing patient clinical these technologies assist healthcare providers diagnosing infections, evaluating their severity, selecting appropriate therapies. While integration settings is still its infancy, quality algorithm suggest that widespread adoption forthcoming. conclusion, holds improving management outcome.

Language: Английский

Citations

14
How to Keep Myofibroblasts under Control: Culture of Mouse Skin Fibroblasts on Soft Substrates DOI
Dong Ok Son, Raquel Benítez, Li Diao

et al.

Journal of Investigative Dermatology, Journal Year: 2024, Volume and Issue: 144(9), P. 1923 - 1934

Published: July 29, 2024

Language: Английский

Citations

4
Protein prenylation in mechanotransduction: implications for disease and therapy DOI
Heng Chen, Jian Yang,

Qingzhen Yang

et al.

Trends in Pharmacological Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Advanced 3D Materials for Corneal Stroma Regeneration: A Preclinical Progress DOI
Amin Orash Mahmoud Salehi, Maryam Soleimani, Kevin Catzim-Ríos

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Corneal stromal defects cause global blindness and entail unmet solutions beyond transplants. This review highlights scaffolds, biomaterials, signaling cues in corneal stroma engineering to advance next-generation vision therapies.

Language: Английский

Citations

0
Mucosa‐Interfacing Capsule for In Situ Sensing the Elasticity of Biological Tissues DOI Creative Commons
Kiyoung Kim, Steven J Edwards,

Kyle Fuxa

et al.

Advanced Materials Technologies, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Monitoring the elasticity of soft biological tissues in gastrointestinal (GI) tract with minimal invasion holds promise for early diagnosis intestinal fibrosis, colorectal cancer, and other diseases featuring abnormal elasticity. However, existing methods sensing tissue have drawbacks such as insufficient resolution elastography, discomfort or requirement risky anesthesia flexible endoscopes implantable devices. Here a wirelessly actuated palpation mechanism is presented, integrated into swallowable capsule device, offering situ measurement invasiveness. The approach employs magnetic cantilever beam by external fields to gently press against tissues. Mechanical stress strain are monitored an onboard sensor gauge, allowing accurate assessment Additionally, wireless modules utilizing Bluetooth Low Energy (LE) powered battery facilitate real‐time communication. device operates under field control, which can move freely over during examinations palpate suspicious areas. validated assessed on both phantom structures ex vivo porcine colon significant assessing physiological conditions facilitating disease hard‐to‐reach areas body.

Language: Английский

Citations

1
Microstring-engineered tension tissues: A novel platform for replicating tissue mechanics and advancing mechanobiology DOI

Zixing Zhou,

Tingting Li,

Wei Cai

et al.

Lab on a Chip, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

A simple, cost-effective approach for fabricating soft microstring chips that enables precise engineering of tension tissues (METTs), advancing research in mechanobiology and biomedical applications.

Language: Английский

Citations

0
Cell membrane-camouflaged nanoparticles activate fibroblast-myofibroblast transition to promote skin wound healing DOI
Qi Jia,

Yijuan Ding,

Ziwen Su

et al.

Biofabrication, Journal Year: 2024, Volume and Issue: 17(1), P. 015036 - 015036

Published: Dec. 10, 2024

Abstract The fibroblast-myofibroblast transition marked by extracellular matrix (ECM) secretion and contraction of actomyosin-based stress fibers, plays central roles in the wound healing process. This work aims to utilize cell membrane-based nanoplatform improve outcomes dysregulated healing. membranes myofibroblasts isolated from mouse skin are used as camouflage for gold nanoparticles loaded with IL-4 cytokine. membrane-modified show effective situ clearance bacterial infection, act activator IL-4Rα signaling pathway induce pro-inflammatory M1 macrophages into anti-inflammatory M2 phenotype. Thus, poor bacteria-clearance non-stop inflammation refractory wounds improved accelerated. Furthermore, releases myofibroblast propel primitive fibroblasts toward an epigenetic manner. Matrix-production, vascularization, epithelial regeneration then initiated, leading satisfactory closure. Our study devises a new strategy activating under prolonged continuous exposure fibrotic environment, develops promising biomimetic treatment chronic

Language: Английский

Citations

0