Bioengineering,
Journal Year:
2024,
Volume and Issue:
11(11), P. 1096 - 1096
Published: Oct. 30, 2024
Recent
advancements
in
biotechnology
forged
the
path
for
clinical
trials
dish
(CTiDs)
to
advance
as
a
popular
method
of
experimentation
biomedicine.
CTiDs
play
fundamental
role
translational
research
through
technologies
such
induced
pluripotent
stem
cells,
whole
genome
sequencing,
and
organs-on-a-chip.
In
this
review,
we
explore
that
enable
these
CTiD
biotechnologies
their
applications
animal
testing,
disease
modeling,
space
radiation
technologies.
Furthermore,
review
dissects
advantages
disadvantages
CTiDs,
well
regulatory
considerations.
Lastly,
evaluate
challenges
pose
future
experimentation.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(12)
Published: Nov. 20, 2024
Abstract
The
gut
microbiota
plays
a
critical
role
in
maintaining
human
health,
influencing
wide
range
of
physiological
processes,
including
immune
regulation,
metabolism,
and
neurological
function.
Recent
studies
have
shown
that
imbalances
composition
can
contribute
to
the
onset
progression
various
diseases,
such
as
metabolic
disorders
(e.g.,
obesity
diabetes)
neurodegenerative
conditions
Alzheimer's
Parkinson's).
These
are
often
accompanied
by
chronic
inflammation
dysregulated
responses,
which
closely
linked
specific
forms
cell
death,
pyroptosis
ferroptosis.
Pathogenic
bacteria
trigger
these
death
pathways
through
toxin
release,
while
probiotics
been
found
mitigate
effects
modulating
responses.
Despite
insights,
precise
mechanisms
influences
diseases
remain
insufficiently
understood.
This
review
consolidates
recent
findings
on
impact
immune‐mediated
inflammation‐associated
conditions.
It
also
identifies
gaps
current
research
explores
potential
advanced
technologies,
organ‐on‐chip
models
microbiome–gut–organ
axis,
for
deepening
our
understanding.
Emerging
tools,
single‐bacterium
omics
spatial
metabolomics,
discussed
their
promise
elucidating
microbiota's
disease
development.
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 10, 2024
Abstract
Molecular
imprinting
technology
(MIT)
stands
out
for
its
exceptional
simplicity
and
customization
capabilities
has
been
widely
employed
in
creating
artificial
antibodies
that
can
precisely
recognize
efficiently
capture
target
molecules.
Concurrently,
nanozymes
have
emerged
as
promising
enzyme
mimics
the
biomedical
field,
characterized
by
their
remarkable
stability,
ease
of
production
scalability,
robust
catalytic
activity,
high
tunability.
Drawing
inspiration
from
natural
enzymes,
molecularly
imprinted
combine
unique
benefits
both
MIT
nanozymes,
thereby
conferring
biomimetic
catalysts
with
substrate
specificity
selectivity.
In
this
review,
latest
strategies
fabrication
focusing
on
use
organic
polymers
inorganic
nanomaterials
are
explored.
Additionally,
cutting‐edge
techniques
generating
atom‐layer‐imprinted
islands
ultra‐thin
atomic‐scale
thickness
is
summarized.
Their
applications
particularly
noteworthy
fields
catalyst
optimization,
detection
techniques,
therapeutic
strategies,
where
they
boost
reaction
selectivity
efficiency,
enable
precise
identification
quantification
substances,
enhance
effectiveness
while
minimizing
adverse
effects.
Lastly,
prevailing
challenges
field
delineate
potential
avenues
future
progress
encapsulated.
This
review
will
foster
advancements
expand
applications.
Lab on a Chip,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Organs-on-chips
(OoCs)
can
be
directly
fabricated
by
3D
bioprinting
techniques,
which
enhance
the
structural
and
functional
fidelity
of
organ
models
broaden
applications
OoCs.
Journal of Environmental Exposure Assessment,
Journal Year:
2025,
Volume and Issue:
4(1)
Published: Feb. 19, 2025
This
perspective
presents
first-hand
research
insights
into
the
pervasive
environmental
distribution
of
neonicotinoid
insecticides
(NEOs)
and
their
consequent
human
exposure.
Our
findings
reveal
widespread
NEO
detection
across
biological
matrices,
indicating
potential
health
risks
highlighting
critical
gaps
in
current
risk
assessment
paradigms.
We
identify
an
urgent
need
for
longitudinal
epidemiological
studies,
particularly
focusing
on
vulnerable
populations,
to
comprehensively
assess
NEO-related
outcomes.
These
scientific
should
inform
evidence-based
policy
reforms
management
strategies
effectively
protect
both
public
integrity.
Chinese Medical Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 25, 2025
Abstract
The
high
failure
rates
in
clinical
drug
development
based
on
animal
models
highlight
the
urgent
need
for
more
representative
human
biomedical
research.
In
response
to
this
demand,
organoids
and
organ
chips
were
integrated
greater
physiological
relevance
dynamic,
controlled
experimental
conditions.
This
innovative
platform—the
organoids-on-a-chip
technology—shows
great
promise
disease
modeling,
discovery,
personalized
medicine,
attracting
interest
from
researchers,
clinicians,
regulatory
authorities,
industry
stakeholders.
review
traces
evolution
organoids-on-a-chip,
driven
by
necessity
advanced
biological
models.
We
summarize
applications
of
simulating
pathological
phenotypes
therapeutic
evaluation
technology.
section
highlights
how
integrating
technologies
chips,
such
as
microfluidic
systems,
mechanical
stimulation,
sensor
integration,
optimizes
organoid
cell
types,
spatial
structure,
functions,
thereby
expanding
their
applications.
conclude
addressing
current
challenges
offering
insights
into
prospects.
advancement
is
poised
enhance
fidelity,
standardization,
scalability.
Furthermore,
integration
cutting-edge
interdisciplinary
collaborations
will
be
crucial
progression
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: March 11, 2025
Organoids
are
stem-cell
derived
tissue
structures
mimicking
specific
structural
and
functional
characteristics
of
human
organs.
Despite
significant
advancements
in
the
field
over
last
decade,
challenges
like
limited
long-term
culture
lack
maturation
hampering
implementation
organoids
biomedical
research.
Culture
microfluidic
chips
is
being
used
to
tackle
these
through
dynamic
precise
control
organoid
microenvironment.
This
review
highlights
breakthroughs
that
have
been
made
innovative
“organoids-on-chip,”
demonstrating
how
contributed
advancing
models.
We
focus
on
incorporation
representative
for
various
tissues
into
discuss
latest
findings
multi-organoids-on-chip
approaches.
Additionally,
we
examine
current
limitations
towards
development
reproducible
organoids-on-chip
systems.
Finally,
potential
technology
both
vitro
vivo
applications.
