The Journey and Modes of Action of Therapeutic Nanomaterials in Cells DOI
Célia Sahli,

Kenry Kenry

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Over past decades, a wide range of nanomaterials have been synthesized and exploited to augment the efficacy biocompatibility disease theranostics nanomedicine. The unique physicochemical properties nanomaterials, such as high specific surface area, tunable size shape, versatile chemistry, enable controlled modulation nanomaterial-biosystem interactions and, consequently, more precise interventions, particularly at cellular level. selective nanomaterial-cell can be leveraged regulate internalization, intracellular trafficking localization, clearance enhance therapeutic minimize potential cytotoxicity. Herein, we provide an overview our recent understanding journey modes action in cells. Specifically, highlight various pathways trafficking, excretion these nanomaterials. different especially release delivery, photothermal photodynamic effects, immunomodulation, are also discussed. We conclude review by offering some perspectives on current challenges opportunities this field.

Language: Английский

Nanomedicine Approaches for Intervertebral Disc Regeneration: From Bench to Bedside DOI Creative Commons
Yifan Ding, Fan Li, Yunyun Wang

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 313 - 313

Published: Feb. 28, 2025

Intervertebral disc degeneration (IDD) is a leading cause of low back pain (LBP) and neurological dysfunction, contributing significantly to disability-adjusted life years globally. The progression IDD driven by excessive oxidative stress, inflammation, apoptosis, fibrosis, which disrupt the balance between anabolic catabolic processes, extracellular matrix (ECM) degradation IDD. Current treatment options, such as conservative therapy surgical intervention, are limited in halting disease often exacerbate adjacent discs. This review highlights challenges treating IDD, particularly due drug delivery efficiency intervertebral (IVD). It explores potential nanobiomedicine various nanomaterial-based systems, including nanoparticles, microspheres, gene-nanocomplexes, fullerene, exosomes, nanomaterial-composite hydrogels. These advanced systems can enhance targeted delivery, improve local concentration, sustain retention within IVD, offering promising therapeutic strategies address also examines effects these nanomaterials on focusing their impact metabolism, stem cell migration differentiation, aiming provide innovative for regeneration.

Language: Английский

Citations

0
Safe-by-design strategies towards bismuth-based nanomaterials in tumor diagnosis and therapy DOI
Xiaoyu Zhang,

Fene Gao,

Yizhi Dai

et al.

Nano Today, Journal Year: 2025, Volume and Issue: 62, P. 102714 - 102714

Published: March 15, 2025

Language: Английский

Citations

0
Nucleic Acid‐Locked Smart Carrier for Photothermal/Chemotherapy‐Amplified Immunogenic Cell Death to Enhance Systemic Antitumor Efficacy DOI Creative Commons
Jiayang Zhang,

Tianyu Gai,

Jiwei Wang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Abstract Immunotherapy holds great promise in the fight against cancer; however, it often encounters poor immunogenicity with limited therapeutic efficacy. Combining multiple treatment modalities provides a trustworthy strategy for achieving robust antitumor effect. In this study, nucleic acid‐locked smart carrier (NASC) is developed to amplify immunogenic cell death (ICD) through synergistic integration of photothermal therapy (PTT) and chemotherapy high‐performance monotherapy. Mesoporous silica‐coated gold nanorod (MSGNR) serves as reservoir anticancer drug doxorubicin (DOX) capped sequence‐specific duplex unit containing tumor‐specific targeting AS1411 fragment, resulting formation NASC. With targeting, NASC can specifically target be internalized into tumor cells high expression nucleolin, where capping unlocked by intracellularly overexpressed adenosine triphosphate. Subsequently, released DOX synergized MSGNR‐mediated PTT following laser irradiation induces direct killing, which, concurrently, triggers ICD activate antineoplastic immunity an increased number T lymphocytes. This triple‐collaborative strategy, further combined anti‐programmed death‐1 antibody (αPD‐1)‐mediated immune checkpoint blockade (ICB) therapy, shows efficacy both unilateral bilateral models.

Language: Английский

Citations

0
The Journey and Modes of Action of Therapeutic Nanomaterials in Cells DOI
Célia Sahli,

Kenry Kenry

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Over past decades, a wide range of nanomaterials have been synthesized and exploited to augment the efficacy biocompatibility disease theranostics nanomedicine. The unique physicochemical properties nanomaterials, such as high specific surface area, tunable size shape, versatile chemistry, enable controlled modulation nanomaterial-biosystem interactions and, consequently, more precise interventions, particularly at cellular level. selective nanomaterial-cell can be leveraged regulate internalization, intracellular trafficking localization, clearance enhance therapeutic minimize potential cytotoxicity. Herein, we provide an overview our recent understanding journey modes action in cells. Specifically, highlight various pathways trafficking, excretion these nanomaterials. different especially release delivery, photothermal photodynamic effects, immunomodulation, are also discussed. We conclude review by offering some perspectives on current challenges opportunities this field.

Language: Английский

Citations

0