3D Bioprinting Inner Ear Organ of Corti Organoids Induce Hair Cell Regeneration

Journal of Biomedical Materials Research Part A, Journal Year: 2025, Volume and Issue: 113(3)

Published: March 1, 2025

ABSTRACT Hearing loss is often regarded as “invisible disability” which seriously affects the quality of life. The majority hearing cases are caused by damage to inner ear hair cells or connected spiral ganglion cells, and there a lack effective treatment measures. In recent years, significant progress has been made in use two‐dimensional (2D) culture systems induce regeneration auditory cells. However, regenerated cannot form functional ciliary bundles under 2D system, let alone establish synaptic contact with so they truly achieve physiological repair hearing. this study, our aim construct three‐dimensional (3D) organ Corti organoid through 3D bioprinting, combines “3D scaffold + multiple induction signals stem cells.” Then we evaluate effects organoids on differentiation into We found that promoted adhesion growth well production nerve research may develop novel approach for studying cell repair.

Language: Английский

Hydrogel-based materials for microbial/enzyme immobilization: Advanced applications in wastewater treatment

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161878 - 161878

Published: March 1, 2025

Language: Английский