Published: Jan. 1, 2024
Language: Английский
Published: Jan. 1, 2024
Language: Английский
Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: unknown, P. 107080 - 107080
Published: Oct. 1, 2024
Language: Английский
Citations
1International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12222 - 12222
Published: Nov. 14, 2024
Helicobacter pylori is a major pathogen associated with various gastric diseases. Despite decades of research, the treatment H. remains challenging. One primary mechanisms contributing to failures therapies targeting this bacterium genetic mutations in drug target sites, although growing body scientific data highlights that efflux pumps may also take part process. Efflux are proteinaceous transporters actively expelling antimicrobial agents from interior targeted cells and reducing intracellular concentration these compounds. Considering contribute both resistance biofilm formation, an in-depth understanding their properties constitute cornerstone development novel therapeutics against pylori. In line this, aim current review describe multitude produced by present describing involvement proteins tolerance and/or classes substances.
Language: Английский
Citations
1Process Biochemistry, Journal Year: 2024, Volume and Issue: 149, P. 169 - 180
Published: Dec. 11, 2024
Language: Английский
Citations
1BMC Genomics, Journal Year: 2024, Volume and Issue: 25(1)
Published: June 17, 2024
Abstract Adhesins are crucial factors in the virulence of bacterial pathogens such as Escherichia coli . However, to date no resources have been dedicated detailed analysis E. adhesins. Here, we provide adhesiomeR software that enables characterization complete adhesin repertoire, termed adhesiome. AdhesiomeR incorporates most comprehensive database adhesins and facilitates an extensive We demonstrate achieves 98% accuracy when compared with experimental analyses. Based on 15,000 genomes, define novel adhesiome profiles clusters, providing a nomenclature for unified comparison adhesiomes.
Language: Английский
Citations
0Published: Jan. 1, 2024
Language: Английский
Citations
0