Fantastic proteins and where to find them – histones, in the nucleus and beyond DOI Creative Commons
Johanna Grinat, Noah P. Shriever, Maria A. Christophorou

et al.

Journal of Cell Science, Journal Year: 2024, Volume and Issue: 137(24)

Published: Dec. 15, 2024

Animal genomes are packaged into chromatin, a highly dynamic macromolecular structure of DNA and histone proteins organised nucleosomes. This accommodates packaging lengthy genomic sequences within the physical confines nucleus while also enabling precise regulation access to genetic information. However, histones existed before chromatin have lesser-known functions beyond genome regulation. Most notably, potent antimicrobial agents, release extracellular space is defence mechanism nearly as ancient widespread itself. Histone changed very little throughout evolution, suggesting possibility that some their 'non-canonical' at play in parallel or concert with regulatory functions. In this Review, we take an evolutionary perspective histone, nuclear biology describe known extranuclear histones. We detail molecular mechanisms sensing, discuss roles physiology disease. Finally, present evidence give on potential act bioactive, cell modulatory factors.

Language: Английский

ACSS2 and metabolic diseases: from lipid metabolism to therapeutic target DOI Creative Commons

Alaa El-Kurjieh,

Reem Al-Arab,

Qamar Abou Hachem

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 25, 2025

Elevated incidence of metabolic disorders has been reported worldwide in the recent decade, highlighting need for developing efficient therapies. These diseases result from a complex interplay various factors that contribute to disease progression, complications, and resistance current treatment options. Acetyl-CoA Synthetase Short Chain Family Member 2 (ACSS2) is nucleo-cytosolic enzyme with both lipogenic regulatory roles. Studies on ACSS2 have shown it involved pathways commonly dysregulated disorders, leading fat deposition disrupted cellular signaling. Although multiple studies suggested role rewiring during tumorigenesis, few examined its involvement pathophysiology diseases. Recent evidence indicates may pathogenesis making examination great interest potentially aiding development new therapeutic strategies. The objective this review summarize understanding ACSS2's potential as target.

Language: Английский

Citations

0
Phospholipid Biosynthesis: An Unforeseen Modulator of Nuclear Metabolism DOI
Hong Qiu, Cunqi Ye

Biology of the Cell, Journal Year: 2025, Volume and Issue: 117(3)

Published: March 1, 2025

ABSTRACT Glycerophospholipid biosynthesis is crucial not only for providing structural components required membrane biogenesis during cell proliferation but also facilitating remodeling under stress conditions. The biosynthetic pathways glycerophospholipid tails, glycerol backbones, and diverse head group classes intersect with various other metabolic processes, sharing intermediary metabolites. Recent studies have revealed intricate connections between synthesis nuclear metabolism, including metabolite‐mediated crosstalk the epigenome, signaling that govern genome integrity, CTP‐involved regulation of nucleotide antioxidant biosynthesis. This review highlights recent advances in understanding functional roles beyond their functions budding yeast mammalian cells. We propose plays an integrative role regulation, a new perspective on lipid biology.

Language: Английский

Citations

0
Lipids and chromatin: a tale of intriguing connections shaping genomic landscapes DOI
Maria Laura Sosa Ponce, Jennifer A. Cobb, Vanina Zaremberg

et al.

Trends in Cell Biology, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Language: Английский

Citations

3
A two-way relationship between histone acetylation and metabolism DOI
Evelina Charidemou, Antonis Kirmizis

Trends in Biochemical Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

2
Acetyltransferase in cardiovascular disease and aging DOI Open Access
Mariko Aoyagi Keller, Michinari Nakamura

The Journal of Cardiovascular Aging, Journal Year: 2024, Volume and Issue: 4(4)

Published: Dec. 31, 2024

Acetyltransferases are enzymes that catalyze the transfer of an acetyl group to a substrate, modification referred as acetylation. Loss-of-function variants in genes encoding acetyltransferases can lead congenital disorders, often characterized by intellectual disability and heart muscle defects. Their activity is influenced dietary nutrients alter coenzyme A levels, key cofactor. Cardiovascular diseases, including ischemic, hypertensive, diabetic diseases - leading causes mortality elderly largely attributed prolonged lifespan growing prevalence metabolic syndrome. thus serve crucial link between lifestyle modifications, cardiometabolic disease, aging through both epigenomic non-epigenomic mechanisms. In this review, we discuss roles relevance acetyltransferases. While sirtuin family deacetylases has been extensively studied longevity, particularly fasting-mediated NAD+ metabolism, recent research brought attention essential health aging-related pathways, cell proliferation, DNA damage response, mitochondrial function, inflammation, senescence. We begin with overview acetyltransferases, classifying them domain structure, canonical non-canonical lysine N-terminal sialic acid O-acetyltransferases. then advances understanding acetyltransferase-related pathologies, focusing on cardiovascular disease aging, explore their potential therapeutic applications for promoting older individuals.

Language: Английский

Citations

2
Nuclear lipids in chromatin regulation: Biological roles, experimental approaches and existing challenges DOI Creative Commons
Ahmed M. Sayed, Karthik Eswara, Kaian Teles

et al.

Biology of the Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 8, 2024

Abstract Lipids are crucial for various cellular functions. Besides the storage of energy equivalents, these include forming membrane bilayers and serving as signaling molecules. While significant progress has been made in comprehension molecular biology lipids, their functions cell nucleus remain poorly understood. The main role eukaryotic is to provide an environment regulation chromatin which a complex DNA, histones, associated proteins. Recent studies suggest that nuclear lipids play epigenetics. Here, we discuss experimental methods lipid‐chromatin research, including biophysical, structural, approaches, pointing out strengths weaknesses. We take view have far more widespread impact on than currently acknowledged. This gap mostly due existing challenges study biology. Several new, interdisciplinary approaches discussed could aid elucidating roles gene expression.

Language: Английский

Citations

0
Fantastic proteins and where to find them – histones, in the nucleus and beyond DOI Creative Commons
Johanna Grinat, Noah P. Shriever, Maria A. Christophorou

et al.

Journal of Cell Science, Journal Year: 2024, Volume and Issue: 137(24)

Published: Dec. 15, 2024

Animal genomes are packaged into chromatin, a highly dynamic macromolecular structure of DNA and histone proteins organised nucleosomes. This accommodates packaging lengthy genomic sequences within the physical confines nucleus while also enabling precise regulation access to genetic information. However, histones existed before chromatin have lesser-known functions beyond genome regulation. Most notably, potent antimicrobial agents, release extracellular space is defence mechanism nearly as ancient widespread itself. Histone changed very little throughout evolution, suggesting possibility that some their 'non-canonical' at play in parallel or concert with regulatory functions. In this Review, we take an evolutionary perspective histone, nuclear biology describe known extranuclear histones. We detail molecular mechanisms sensing, discuss roles physiology disease. Finally, present evidence give on potential act bioactive, cell modulatory factors.

Language: Английский

Citations

0