Fetal adnexa-derived allogeneic mesenchymal stem cells for cardiac regeneration: the future trend of cell-based therapy for age-related adverse conditions

Human Cell, Journal Year: 2025, Volume and Issue: 38(2)

Published: Feb. 25, 2025

Language: Английский

Ethical considerations for advancing research using organoid models derived from the placenta

Human Reproduction Update, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract BACKGROUND The advent of organoid culture systems has revolutionized our ability to model and study complex tissues in vitro. placenta is one the last human organs have a functional developed: trophoblast organoids. These 3-dimensional structures, derived from placental tissue, offer researchers valuable tool for studying previously inaccessible processes that occur within womb play significant role determining health offspring. While primarily used research, organoids hold promise clinical applications, including prenatal diagnostics therapeutic interventions, both which may commercial interest. However, ensure research with models conducted responsibly, relevant ethics these need be addressed. OBJECTIVE AND RATIONALE Ethical considerations related placenta, such as are important but remain unexplored literature. Therefore, goal this review explore ethical SEARCH METHODS Since there no specifically addressing date, we based findings on discussions other involving fetal or umbilical cord blood. We employed scoping method search PubMed, Embase, Medline (all), Bioethics Research Library, Google Scholar articles, books, correspondence issues regarding indicated topics, date limits. OUTCOMES can divided into three distinct categories. First, assess moral value organoids, their potential relational symbolic dimensions. Second, it understand associated ownership commercialization Last, appropriate informed consent procedures. It worth noting categories interconnected, second third being largely dependent attributed Future should perspectives various stakeholders, parents who donate tissue research. WIDER IMPLICATIONS This offers insights landscape surrounding derivation products pregnancies, further application, highlighting areas require attention discussion scientific community broader society. REGISTRATION NUMBER N/A.

Language: Английский

Beyond Consciousness: Ethical, Legal, and Social Issues in Human Brain Organoid Research and Application

European Journal of Cell Biology, Journal Year: 2024, Volume and Issue: 104(1), P. 151470 - 151470

Published: Dec. 19, 2024

Language: Английский